MOMA Cancer Panel v4 - Subpanels (updated 2021-10-01)

Cancer subpanels valid from 2021-10-01

 

Breastcancer and Ovarian cancer v1
ATM, BRCA1, BRCA2, BRIP1, CDH1, CHEK2, EPCAM**, MLH1, MSH2, MSH6, PALB2, PTEN, RAD51C, RAD51D, STK11, TP53

Colorectal Cancer and Polyposis v2
APC, AXIN2, BMPR1A, EPCAM**, MLH1, MLH3, MSH2, MSH3, MSH6, MUTYH, NTHL1, PMS2*, POLD1, POLE, PTEN, RNF43, RPS20, SCG5 (GREM1-enhancer)**, SMAD4, STK11, TP53

Prostate cancer v1
BRCA1, BRCA2, EPCAM**, MLH1, MSH2, MSH6, PMS2*

Carney syndrome v1
PRKAR1A

Lynch syndrome v2
EPCAM**, MLH1, MSH2, MSH6, PMS2*

Multiple Endocrine Neoplasia v3
AIP, AP2S1, CASR, CDC73, CDKN1A, CDKN1B, CDKN2B, CDKN2C, GNA11, GNAS, MEN1, NTRK1, PRKAR1A, RET, SDHB, SDHC, SDHD, VHL

Neurofibromatosis v1
NF1, NF2, SPRED1

Kidney cancer v3
BAP1, CDKN2B, FH, FLCN, MET, MITF, PTEN, SDHA, SDHAF2, SDHB, SDHC, VHL

Gorlin syndrome v3
PTCH1, PTCH2, SUFU

Li-Fraumeni syndrome v1
TP53

Peutz-Jegher syndrome v1
STK11

HDGC, Hereditary Diffuse Gastric Cancer v2
CDH1, CTNNA1

Maligne melanome v1
ACD, BAP1, BRCA2, CDK4, CDKN2A, MITF, POLE, POT1, TERF2IP, TERT

Pancreas cancer v1
BRCA1, BRCA2, CDKN2A, EPCAM**, MLH1, MSH2, MSH6, PALB2, PMS2*, PRSS1, STK11

Schwannomatosis v2
SMARCB1, LZTR1, NF2

* MLPA part of analysis **Only CNV analysis