MOMA Next-generation sequencing Gene Panels

 


The NGS analysis comprises coding exons of the listed genes plus 10 bp of the flanking introns with a minimum coverage of 30x.

 

List of genes included in "MOMA hereditary cancer-panel version 1" and "MOMA heart panel version 1", 2013-09-01.

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Gene symbol Gene name HGNC ID location Disease panel
AIP aryl hydrocarbon receptor interacting protein HGNC:358 11q13.3 hereditary cancer
APC adenomatous polyposis coli HGNC:583 5q21-q22 hereditary cancer
ATM ataxia telangiectasia mutated HGNC:795 11q22-q23 hereditary cancer
AXIN2 axin 2 HGNC:904 17q23-q24 hereditary cancer
BARD1 BRCA1 associated RING domain 1 HGNC:952 2q34-q35 hereditary cancer
BMPR1A bone morphogenetic protein receptor, type IA HGNC:1076 10q22.3 hereditary cancer
BRAF v-raf murine sarcoma viral oncogene homolog B1 HGNC:1097 7q34 hereditary cancer
BRCA1 breast cancer 1, early onset HGNC:1100 17q21.31 hereditary cancer
BRCA2 breast cancer 2, early onset HGNC:1101 13q12-q13 hereditary cancer
BRIP1 BRCA1 interacting protein C-terminal helicase 1 HGNC:20473 17q22.2 hereditary cancer
CASR calcium-sensing receptor HGNC:1514 3q21.1 hereditary cancer
CDC73 cell division cycle 73 HGNC:16783 1q25 hereditary cancer
CDH1 cadherin 1, type 1, E-cadherin (epithelial) HGNC:1748 16q22.1 hereditary cancer
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) HGNC:1784 6p21.1 hereditary cancer
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) HGNC:1785 12p13.1-p12 hereditary cancer
CDKN2A cyclin-dependent kinase inhibitor 2A HGNC:1787 9p21 hereditary cancer
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) HGNC:1788 9p21 hereditary cancer
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) HGNC:1789 1p32.3 hereditary cancer
CHEK1 checkpoint kinase 1 HGNC:1925 11q24.2 hereditary cancer
CHEK2 checkpoint kinase 2 HGNC:16627 22q12.1 hereditary cancer
DHFR dihydrofolate reductase HGNC:2861 5q11.2-q13.2 hereditary cancer
ENG endoglin HGNC:3349 9q34.11 hereditary cancer
EPCAM epithelial cell adhesion molecule HGNC:11529 2p21 hereditary cancer
EXO1 exonuclease 1 HGNC:3511 1q42-q43 hereditary cancer
FAM175A family with sequence similarity 175, member A HGNC:25829 4q21.23 hereditary cancer
FH fumarate hydratase HGNC:3700 1q42.1 hereditary cancer
FLCN folliculin HGNC:27310 17p11.2 hereditary cancer
GALNT12 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 12 (GalNAc-T12) HGNC:19877 9q22.33 hereditary cancer
GNAS GNAS complex locus HGNC:4392 20q13.2-q13.3 hereditary cancer
KRAS v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog HGNC:6407 12p12.1 hereditary cancer
MEN1 multiple endocrine neoplasia I HGNC:7010 11q13 hereditary cancer
MET met proto-oncogene (hepatocyte growth factor receptor) HGNC:7029 7q31 hereditary cancer
MGMT O-6-methylguanine-DNA methyltransferase HGNC:7059 10q26 hereditary cancer
MLH1 mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) HGNC:7127 3p22.3 hereditary cancer
MLH3 mutL homolog 3 (E. coli) HGNC:7128 14q24.3 hereditary cancer
MRE11A MRE11 meiotic recombination 11 homolog A (S. cerevisiae) HGNC:7230 11q21 hereditary cancer
MSH2 mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli) HGNC:7325 2p21 hereditary cancer
MSH3 mutS homolog 3 (E. coli) HGNC:7326 5q11-q12 hereditary cancer
MSH6 mutS homolog 6 (E. coli) HGNC:7329 2p16 hereditary cancer
MUTYH mutY homolog (E. coli) HGNC:7527 1p34.1 hereditary cancer
NBN nibrin HGNC:7652 8q21-q24 hereditary cancer
NF1 neurofibromin 1 HGNC:7765 17q11.2 hereditary cancer
NF2 neurofibromin 2 (merlin) HGNC:7773 22q12.2 hereditary cancer
NTRK1 neurotrophic tyrosine kinase, receptor, type 1 HGNC:8031 1q21-q22 hereditary cancer
OGG1 8-oxoguanine DNA glycosylase HGNC:8125 3p26 hereditary cancer
PALB2 partner and localizer of BRCA2 HGNC:26144 16p12.1 hereditary cancer
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha HGNC:8975 3q26.3 hereditary cancer
PMS1 PMS1 postmeiotic segregation increased 1 (S. cerevisiae) HGNC:9121 2q31-q33 hereditary cancer
PMS2 PMS2 postmeiotic segregation increased 2 (S. cerevisiae) HGNC:9122 7p22.1 hereditary cancer
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha HGNC:9388 17q23-q24 hereditary cancer
PTCH1 patched 1 HGNC:9585 9q22.1-q31 hereditary cancer
PTEN phosphatase and tensin homolog HGNC:9588 10q23 hereditary cancer
PTPN11 protein tyrosine phosphatase, non-receptor type 11 HGNC:9644 12q24.1 hereditary cancer
RAD50 RAD50 homolog (S. cerevisiae) HGNC:9816 5q23-q31 hereditary cancer
RAD51 RAD51 recombinase HGNC:9817 15q15.1 hereditary cancer
RAD51C RAD51 paralog C HGNC:9820 17q25.1 hereditary cancer
RAD51D RAD51 paralog D HGNC:9823 17q11 hereditary cancer
RET ret proto-oncogene HGNC:9967 10q11.2 hereditary cancer
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip) HGNC:10681 1p36.1-p35 hereditary cancer
SDHD succinate dehydrogenase complex, subunit D, integral membrane protein HGNC:10683 11q23 hereditary cancer
SMAD4 SMAD family member 4 HGNC:6770 18q21.1 hereditary cancer
SPRED1 sprouty-related, EVH1 domain containing 1 HGNC:20249 15q14 hereditary cancer
STK11 serine/threonine kinase 11 HGNC:11389 19p13.3 hereditary cancer
TGFB1 transforming growth factor, beta 1 HGNC:11766 19q13.1 hereditary cancer
TP53 tumor protein p53 HGNC:11998 17p13.1 hereditary cancer
TP73 tumor protein p73 HGNC:12003 1p36.3 hereditary cancer
TYMS thymidylate synthetase HGNC:12441 18p11.31-p11.21 hereditary cancer
UIMC1 ubiquitin interaction motif containing 1 HGNC:30298 5q35.2 hereditary cancer
VHL von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase HGNC:12687 3p25.3 hereditary cancer
XRCC2 X-ray repair complementing defective repair in Chinese hamster cells 2 HGNC:12829 7q36 hereditary cancer
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3 HGNC:12830 14q32.3 hereditary cancer