Gene Panels Cancer v3 and Heart v4

The NGS panels by syndrome are subpanels of the "MOMA Hereditary Cancer Panel v3" or "MOMA Heart Panel v4", respectively. 
They can be ordered alone or in combination. Subsequent ordering of subpanels is possible at a fixed fee.

The panel "Thoracic aorta dilation" is ordered and analyzed seperately from the "MOMA Heart Panel".

"Exome,endocrinology" is not yet an accredited method in the laboratory.

MOMA Hereditary Cancer Panel (targeted NGS) v3 - 106 genes, 2017-01-01

Please see the full list of genes here:

MOMA Cancerpanel v3 (updated 2019-07-01)

Subpanels (valid from July 1st 2019):

Breastcancer v2
BRCA1, BRCA2, PALB2, PTEN, STK11, TP53

Ovarycancer v3
BRCA1, BRCA2, BRIP1, EPCAM, MLH1, MSH2, MSH6, PMS2*, RAD51C, RAD51D, STK11

Other breast-/ovarycancer related genes v1
ATM, BARD1, CHEK2, FAM175A, FANCM, GEN1, MRE11A, NBN, PIK3CA, PPM1D, RINT1, XRCC2

CRC disposition v1
APC, AXIN2, BMPR1A, EPCAM, GREM1-enhancer, MLH1, MSH2, MSH3, MSH6, MUTYH, NTHL1, PMS2*, POLD1, POLE, PTEN, SMAD4, STK11

Lynch syndrome v1
EPCAM, MLH1 , MLH3, MSH2, MSH3, MSH6, PMS2*

FAP og MAP v1
APC, MUTYH

Polyposis v1
BMPR1A, ENG, PTCH1, PTEN, SMAD4, STK11, GREM1-enhancer

Multiple Endocrine Neoplasia v3
AIP, AP2S1, CASR, CDC73, CDKN1A, CDKN1B, CDKN2B, CDKN2C, GNA11, GNAS, MEN1, NTRK1, PRKAR1A, RET, SDHB, SDHC, SDHD, VHL

Neurofibromatosis v1
NF1, NF2, SPRED1

Kidneycancer v3
BAP1, CDKN2B, FH, FLCN, MET, MITF, PTEN, SDHA, SDHAF2,SDHB, SDHC, VHL

Gorlin syndrome v3
PTCH1, PTCH2, SUFU

Li-Fraumeni syndrome v1
TP53

Peutz-Jegher syndrome v1
STK11

Hereditary Diffuse Gastric Cancer (HDGC) v1
CDH1

* MLPA is part of the analysis

 

MOMA Heart Panel (targeted NGS) v4 -102 genes, 2018-08-15

Please see the full list of genes here.

MOMA Heart Panel v4

Subpanels:

Cardiomyopathy

ABCC9, ACTC1, ACTN2, ANKRD1 , BAG3, CDH2, CRYAB , CSRP3, CTNNA3 , DES, DMD, DNAJC19, DSC2, DSG2, DSP, DTNA, EMD, EYA4, FHL1, FHL2, FKTN, FLNC, FXN, GATA4, GLA, GAA, JPH2, JUP, LAMA4, LAMP2, LDB3, LMNA, MYBPC3, MYH6, MYH7, MYL2, MYL3, MYOZ2, MYPN, NEBL, NEXN, PKP2, PLN, PRDM16, PRKAG2, PSEN1, PSEN2, PTPN11, RAF1, RBM20, RYR2, SCN5A, SGCD, TAZ, TCAP, TMEM43, TMPO, TNNC1, TNNI3, TNNT2, TPM1, TTN, VCL, ZBTB17

Primary hereditary arrithmia

AKAP9, ANK2, ANO1, BEST3, CACNA1C, CACNA2D1, CACNB2, CALM1, CALM2, CALM3, CASQ2, CAV3, GPD1L, HCN4, KCND3, KCNE1 , KCNE2, KCNE3, KCNE5, KCNH2 , KCNJ2 , KCNJ5, KCNJ8, KCNQ1 , LMNA, RANGRF, RYR2, SCN10A, SCN1B, SCN2B, SCN3B, SCN4B, SCN5A, SLC4A3, SNTA1, TRDN, TRPM4

Familial hypercholesterolemia

APOB, LDLR, PCSK9

Amyloidosis

TTR

 

Panel Thoracic Aorta Dilation v4, 27 genes, 2018-08-15

MOMA Thoracic Aorta Dilation

For more information in Danish, please refer to the website of the Department of Molecular Medicine at Aarhus University Hospital.