Gene Panels Cancer v3 and Heart v4

The NGS panels by syndrome are subpanels of the "MOMA Hereditary Cancer Panel v3" or "MOMA Heart Panel v4", respectively. 
They can be ordered alone or in combination. Subsequent ordering of subpanels is possible at a fixed fee.

The panel "Thoracic aorta dilation" is ordered and analyzed seperately from the "MOMA Heart Panel".

"Exome,endocrinology" is not yet an accredited method in the laboratory.

MOMA Hereditary Cancer Panel (targeted NGS) v3 - 107 genes, 2017-01-01

Please see the full list of genes here:

MOMA Cancerpanel v3

Subpanels (valid from August, 15th 2018):

BRCA and PALP2
BRCA1, BRCA2, PALP2

Breastcancer
BRCA1, BRCA2, CDH1, PALB2, PTEN, RAD51C, RAD51D, STK11, TP53

Ovarycancer
BRCA1, BRCA2, BRIP1, EPCAM*, MLH1*, MSH2*, MSH6, PMS2*, RAD51C, RAD51D, STK11

Other breast-/ovarycancer related genes
ABRAXAS1, ATM, BARD1, CHEK2, FANCM, GEN1, MRE11, NBN, PIK3CA, PPM1D, RINT1, XRCC2

CRC disposition
APC, AXIN2, BMPR1A, EPCAM*, GREM1-enhancer, MLH1*, MSH2*, MSH3, MSH6, MUTYH, NTHL1, PMS2*, POLD1, POLE, PTEN, SMAD4, STK11

Lynch syndrome
EPCAM*, MLH1* , MLH3, MSH2*, MSH3, MSH6, PMS2*

FAP og MAP
APC, MUTYH

Polyposis
BMPR1A, ENG, PTCH1, PTEN, SMAD4, STK11, GREM1-enhancer

Multiple Endocrine Neoplasia
AIP, AP2S1, CASR, CDC73, CDKN1A, CDKN1B, CDKN2B, CDKN2C, GNA11, GNAS, MEN1, NTRK1, PRKAR1A, RET, SDHB, SDHC, SDHD, VHL

Neurofibromatosis
NF1*, NF2, SPRED1

Kidneycancer
CDKN2B, FH, FLCN, MET, MITF, PTEN, SDHB, SDHC, VHL

Gorlin syndrome
PTCH1, PTCH2, SUFU

Li-Fraumeni syndrome
TP53

Peutz-Jegher syndrome
STK11

* MLPA is part of the analysis

 

MOMA Heart Panel (targeted NGS) v4 -102 genes, 2018-08-15

Please see the full list of genes here.

MOMA Heart Panel v4

Subpanels:

Cardiomyopathy

ABCC9, ACTC1, ACTN2, ANKRD1 , BAG3, CDH2, CRYAB , CSRP3, CTNNA3 , DES, DMD, DNAJC19, DSC2, DSG2, DSP, DTNA, EMD, EYA4, FHL1, FHL2, FKTN, FLNC, FXN, GATA4, GLA, GAA, JPH2, JUP, LAMA4, LAMP2, LDB3, LMNA, MYBPC3, MYH6, MYH7, MYL2, MYL3, MYOZ2, MYPN, NEBL, NEXN, PKP2, PLN, PRDM16, PRKAG2, PSEN1, PSEN2, PTPN11, RAF1, RBM20, RYR2, SCN5A, SGCD, TAZ, TCAP, TMEM43, TMPO, TNNC1, TNNI3, TNNT2, TPM1, TTN, VCL, ZBTB17

Primary hereditary arrithmia

AKAP9, ANK2, ANO1, BEST3, CACNA1C, CACNA2D1, CACNB2, CALM1, CALM2, CALM3, CASQ2, CAV3, GPD1L, HCN4, KCND3, KCNE1 , KCNE2, KCNE3, KCNE5, KCNH2 , KCNJ2 , KCNJ5, KCNJ8, KCNQ1 , LMNA, RANGRF, RYR2, SCN10A, SCN1B, SCN2B, SCN3B, SCN4B, SCN5A, SLC4A3, SNTA1, TRDN, TRPM4

Familial hypercholesterolemia

APOB, LDLR, PCSK9

Amyloidosis

TTR

 

Panel Thoracic Aorta Dilation v4, 27 genes, 2018-08-15

MOMA Thoracic Aorta Dilation

For more information in Danish, please refer to the website of the Department of Molecular Medicine at Aarhus University Hospital.