MOMA Next-generation sequencing Gene Panels

The NGS analysis comprises coding exons of the listed genes plus 10 bp* of the flanking introns with a minimum coverage of 30x.

 * 30 bp for gene NF1

List of genes included in "MOMA hereditary cancer-panel version 2", 2014-09-30.

Symbol Name Disease panel
AIP aryl hydrocarbon receptor interacting protein cancer: multiple endocrine neoplasia
APC adenomatous polyposis coli cancer: FAP, MAP
ATM ATM serine/threonine kinase cancer
AXIN2 axin 2 cancer: CRC
BARD1 BRCA1 associated RING domain 1 cancer
BLM Bloom syndrome, RecQ helicase-like cancer
BMPR1A bone morphogenetic protein receptor, type IA cancer: CRC, polyposis
BRAF B-Raf proto-oncogene, serine/threonine kinase cancer: other CRC-related
BRCA1 breast cancer 1, early onset cancer: ovary
BRCA2 breast cancer 2, early onset cancer: ovary
BRIP1 BRCA1 interacting protein C-terminal helicase 1 cancer: ovary
CASR calcium-sensing receptor cancer: multiple endocrine neoplasia
CDC73 cell division cycle 73 cancer: multiple endocrine neoplasia
CDH1 cadherin 1, type 1, E-cadherin (epithelial) cancer: other CRC-related
CDK4 cyclin-dependent kinase 4 cancer
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) cancer: multiple endocrine neoplasia
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) cancer: multiple endocrine neoplasia
CDKN2A cyclin-dependent kinase inhibitor 2A cancer: other CRC-related
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) cancer: multiple endocrine neoplasia
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) cancer: multiple endocrine neoplasia
CDKN2D cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4) cancer
CHEK1 checkpoint kinase 1 cancer
CHEK2 checkpoint kinase 2 cancer: other CRC-related
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa cancer: other CRC-related
DHFR dihydrofolate reductase cancer
ENG endoglin cancer: CRC, polyposis
EPCAM epithelial cell adhesion molecule cancer: CRC, other CRC-related, ovary
EXO1 exonuclease 1 cancer: CRC
FAM175A family with sequence similarity 175, member A cancer
FANCC Fanconi anemia, complementation group C cancer
FH fumarate hydratase cancer: kidney
FLCN folliculin cancer: other CRC-related, kidney
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12 cancer: other CRC-related
GNAS GNAS complex locus cancer: multiple endocrine neoplasia
HOXB13 homeobox B13 cancer
KRAS Kirsten rat sarcoma viral oncogene homolog cancer: other CRC-related
MCC mutated in colorectal cancers cancer: other CRC-related
MEN1 multiple endocrine neoplasia I cancer: multiple endocrine neoplasia
MET MET proto-oncogene, receptor tyrosine kinase cancer: kidney
MGMT O-6-methylguanine-DNA methyltransferase cancer: other CRC-related
MLH1 mutL homolog 1 cancer: CRC
MLH3 mutL homolog 3 cancer: CRC
MRE11A MRE11 meiotic recombination 11 homolog A (S. cerevisiae) cancer
MSH2 mutS homolog 2 cancer: CRC
MSH3 mutS homolog 3 cancer: CRC
MSH6 mutS homolog 6 cancer: CRC
MUTYH mutY homolog cancer: CRC, FAP
NBN nibrin cancer
NF1 neurofibromin 1 cancer: CRC
NF2 neurofibromin 2 (merlin) cancer: CRC
NTRK1 neurotrophic tyrosine kinase, receptor, type 1 cancer: multiple endocrine neoplasia
OGG1 8-oxoguanine DNA glycosylase cancer: other CRC-related
PALB2 partner and localizer of BRCA2 cancer
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha cancer: other CRC-related
PMS1 PMS1 postmeiotic segregation increased 1 (S. cerevisiae) cancer: other CRC-related
PMS2 PMS2 postmeiotic segregation increased 2 (S. cerevisiae) cancer: CRC
POLD1 polymerase (DNA directed), delta 1, catalytic subunit cancer: CRC
POLE polymerase (DNA directed), epsilon, catalytic subunit cancer: CRC
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha cancer: multiple endocrine neoplasia
PTCH1 patched 1 cancer: CRC
PTEN phosphatase and tensin homolog cancer: CRC
PTPN11 protein tyrosine phosphatase, non-receptor type 11 cancer
RAD50 RAD50 homolog (S. cerevisiae) cancer
RAD51 RAD51 recombinase cancer
RAD51C RAD51 paralog C cancer
RAD51D RAD51 paralog D cancer
RET ret proto-oncogene cancer: multiple endocrine neoplasia
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip) cancer: multiple endocrine neoplasia
SDHC succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa cancer: multiple endocrine neoplasia
SDHD succinate dehydrogenase complex, subunit D, integral membrane protein cancer: multiple endocrine neoplasia
SFXN4 sideroflexin 4 cancer
SMAD4 SMAD family member 4 cancer: CRC
SPRED1 sprouty-related, EVH1 domain containing 1 cancer: NF
STK11 serine/threonine kinase 11 cancer: CRC
TGFB1 transforming growth factor, beta 1 cancer: other CRC-related
TP53 tumor protein p53 cancer: CRC
TP73 tumor protein p73 cancer: other CRC-related
TWSG1 twisted gastrulation BMP signaling modulator 1 cancer
TYMS thymidylate synthetase cancer: other CRC-related
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats cancer
UIMC1 ubiquitin interaction motif containing 1 cancer
VHL von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase cancer: multiple endocrine neoplasia, kidney
XRCC2 X-ray repair complementing defective repair in Chinese hamster cells 2 cancer
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3 cancer