Publications
2023
Improved protocol for single-nucleus RNA-sequencing of frozen human bladder tumor biopsies.
Schmøkel SS, Nordentoft I, Lindskrog SV, Lamy P, Knudsen M, Jensen JB, Dyrskjøt L.
Nucleus. 2023 Dec;14(1):2186686. doi: 10.1080/19491034.2023.2186686. PubMed
Evolution of the germline mutation rate across vertebrates.
Bergeron LA, Besenbacher S, Zheng J, Li P, Bertelsen MF, Quintard B, Hoffman JI, Li Z, St Leger J, Shao C, Stiller J, Gilbert MTP, Schierup MH, Zhang G.
Nature. 2023 Mar 1. doi: 10.1038/s41586-023-05752-y. Online ahead of print. PubMed Twitter
Epidemiology and diagnostic trends of congenital adrenal hyperplasia in Denmark: a retrospective, population-based study.
Berglund A, Ornstrup MJ, Lind-Holst M, Dunø M, Bækvad-Hansen M, Juul A, Borch L, Jørgensen N, Rasmussen ÅK, Andersen M, Main KM, Hansen D, Gravholt CH.
Lancet Reg Health Eur. 2023 Feb 28;28:100598. doi: 10.1016/j.lanepe.2023.100598. eCollection 2023 May. PubMed Twitter
Identifying Recurrences Among Non-Metastatic Colorectal Cancer Patients Using National Health Data Registries: Validation and Optimization of a Registry-Based Algorithm in a Modern Danish Cohort.
Nors J, Mattesen TB, Cronin-Fenton D, Mailhac A, Bramsen JB, Gotschalck KA, Erichsen R, Andersen CL.
Clin Epidemiol. 2023 Feb 27;15:241-250. doi: 10.2147/CLEP.S396140. eCollection 2023. PubMed Twitter Claus Lindbjerg Twitter Jesper Nors
Field cancerization impacts tumor development, T-cell exhaustion and clinical outcomes in bladder cancer
Trine Strandgaard, Iver Nordentoft, Karin Birkenkamp-Demtröder, Liina Salminen, Frederik Prip, Julie Rasmussen, Tine Ginnerup Andreasen, Sia Viborg Lindskrog, Emil Christensen, Philippe Lamy, Michael Knudsen, Torben Steiniche, Jørgen Bjerggaard Jensen, Lars Dyrskjøt
bioRxiv 2023.02.20.528920; doi: https://doi.org/10.1101/2023.02.20.528920 Preprint Twitter
Cell-free urine- and plasma DNA mutational analysis predicts neoadjuvant chemotherapy response and outcome in patients with muscle invasive bladder cancer.
Christensen E, Nordentoft I, Birkenkamp-Demtroder K, Elbæk SK, Lindskrog SV, Taber A, Andreasen TG, Strandgaard T, Knudsen M, Lamy P, Agerbæk M, Jensen JB, Dyrskjøt L.
Clin Cancer Res. 2023 Feb 13:CCR-22-3250. doi: 10.1158/1078-0432.CCR-22-3250. Online ahead of print. PubMed Twitter
Impact of Whole Genome Doubling on Detection of Circulating Tumor DNA in Colorectal Cancer.
Kabel J, Henriksen TV, Demuth C, Frydendahl A, Rasmussen MH, Nors J, Birkbak NJ, Madsen AH, Løve US, Andersen PV, Kolbro T, Monti A, Thorlacius-Ussing O, Gögenur M, Kildsig J, Schlesinger NH, Bondeven P, Iversen LH, Gotschalck KA, Andersen CL.
Cancers (Basel). 2023 Feb 10;15(4):1136. doi: 10.3390/cancers15041136. PubMed Twitter
Prognostic Value of Low-Pass Whole Genome Sequencing of Circulating Tumor DNA in Metastatic Castration-Resistant Prostate Cancer.
Nørgaard M, Bjerre MT, Fredsøe J, Vang S, Jensen JB, De Laere B, Grönberg H, Borre M, Lindberg J, Sørensen KD.
Clin Chem. 2023 Feb 10:hvac224. doi: 10.1093/clinchem/hvac224. Online ahead of print. PubMed
The ratio of adaptive to innate immune cells differs between genders and associates with improved prognosis and response to immunotherapy.
Ahrenfeldt J, Christensen DS, Østergaard AB, Kisistók J, Sokač M, Birkbak NJ.
PLoS One. 2023 Feb 6;18(2):e0281375. doi: 10.1371/journal.pone.0281375. eCollection 2023. PubMed Twitter
Bladder preservation after neoadjuvant therapy - 2021 IBCN updates part 1.
Hensley PJ, Seiler R, Herr H, Mouw KW, Iyer G, Dyrskjøt L, Nawroth R, Goebell P, Schmitz-Drager B, Todenhofer T, Black PC, Kamat AM, Williams SB.
Urol Oncol. 2023 Jan 24:S1078-1439(23)00001-7. doi: 10.1016/j.urolonc.2023.01.001. Online ahead of print. PubMed
Editorial: Cutting edge basic and clinical bladder cancer research - the IBCN updates.
Goebell PJ, Kamat AM, Black PC, Dyrskjøt L, Nawroth R, Seiler R, Todenhöfer T, Williams SB, Schmitz-Dräger BJ.
Urol Oncol. 2023 Jan 12:S1078-1439(22)00498-7. doi: 10.1016/j.urolonc.2022.12.013. Online ahead of print. PubMed Twitter
DaBlaCa-13 Study: Oncological Outcome of Short-Term, Intensive Chemoresection With Mitomycin in Nonmuscle Invasive Bladder Cancer: Primary Outcome of a Randomized Controlled Trial.
Lindgren MS, Hansen E, Azawi N, Nielsen AM, Dyrskjøt L, Jensen JB.
J Clin Oncol. 2023 Jan 10;41(2):206-211. doi: 10.1200/JCO.22.00470. Epub 2022 Oct 12. PubMed
2022
A method to build extended sequence context models of point mutations and indels.
Bethune J, Kleppe A, Besenbacher S.
Nat Commun. 2022 Dec 22;13(1):7884. doi: 10.1038/s41467-022-35596-5. PubMed Twitter
Identification of a high-risk immunogenic prostate cancer patient subset as candidates for T-cell engager immunotherapy and the introduction of a novel albumin-fused anti-CD3 × anti-PSMA bispecific design.
Glud EN, Rasmussen M, Zhang Y, Mandrup OA, Salachan PV, Borre M, Sørensen KD, Howard KA.
Br J Cancer. 2022 Dec;127(12):2186-2197. doi: 10.1038/s41416-022-01994-1. Epub 2022 Oct 15. PubMed
Computational Analysis Reveals the Temporal Acquisition of Pathway Alterations during the Evolution of Cancer.
Ahrenfeldt J, Christensen DS, Sokač M, Kisistók J, McGranahan N, Birkbak NJ.
Cancers (Basel). 2022 Nov 25;14(23):5817. doi: 10.3390/cancers14235817. PubMed
25 years International Bladder Cancer Network (IBCN): The past, the present, and the future.
Dyrskjøt L, Vlahou A, Black PC, Droller M, Grossmann HB, Goebell PJ, Kamat AM, Nawroth R, Seiler R, Todenhöfer T, Williams SB, Schmitz-Dräger BJ.
Urol Oncol. 2022 Nov 24:S1078-1439(22)00430-6. doi: 10.1016/j.urolonc.2022.10.031. Online ahead of print. PubMed
IBCN Seminar Series 2021: Circulating tumor DNA in bladder cancer.
Christensen E, Wyatt AW, Galsky MD, Grivas P, Seiler R, Nawroth R, Goebell PJ, Schmitz-Drager BJ, Williams SB, Black PC, Kamat AM, Todenhöfer T, Dyrskjøt L.
Urol Oncol. 2022 Nov 24:S1078-1439(22)00442-2. doi: 10.1016/j.urolonc.2022.11.008. Online ahead of print.
PMID: 36437155 Review. No abstract available. PubMed
Cost-Effectiveness Analysis of Stockholm 3 Testing Compared to PSA as the Primary Blood Test in the Prostate Cancer Diagnostic Pathway: A Decision Tree Approach.
Risør BW, Tayyari Dehbarez N, Fredsøe J, Sørensen KD, Pedersen BG.
Appl Health Econ Health Policy. 2022 Nov;20(6):867-880. doi: 10.1007/s40258-022-00741-0. Epub 2022 Aug 8. PubMed
Platelet aggregation in Klinefelter syndrome is not aggravated by testosterone replacement therapy: A longitudinal follow-up study.
Chang S, Larsen OH, Hvas AM, Skakkebaek A, Gravholt CH, Münster AB. Andrology. 2022 Oct 27. doi: 10.1111/andr.13330. Epub ahead of print. PubMed
Biology of BCG response in non-muscle invasive bladder cancer - 2021 IBCN Updates Part III.
Reike MJ, Ingersoll MA, Müller DC, Zuiverloon TCM, Strandgaard T, Kamat AM, Williams SB, Seiler R, Todenhöfer T, Dyrskjøt L, Nawroth R, Goebell P, Schmitz-Dräger B, Sfakianos JP, Meeks J, Horowitz A, Black PC.
Urol Oncol. 2022 Oct 17:S1078-1439(22)00340-4. doi: 10.1016/j.urolonc.2022.09.012. Online ahead of print. PubMed
FGFR3 Mutational Activation Can Induce Luminal-like Papillary Bladder Tumor Formation and Favors a Male Sex Bias.
Shi MJ, Fontugne J, Moreno-Vega A, Meng XY, Groeneveld C, Dufour F, Kamoun A, Viborg Lindskrog S, Cabel L, Krucker C, Rapinat A, Dunois-Larde C, Lepage ML, Chapeaublanc E, Levrel O, Dixon V, Lebret T, Almeida A, De Reynies A, Rochel N, Dyrskjøt L, Allory Y, Radvanyi F, Bernard-Pierrot I.
Eur Urol. 2023 Jan;83(1):70-81. doi: 10.1016/j.eururo.2022.09.030. Epub 2022 Oct 21. PubMed
Identification of a high-risk immunogenic prostate cancer patient subset as candidates for T-cell engager immunotherapy and the introduction of a novel albumin-fused anti-CD3 × anti-PSMA bispecific design.
Glud EN, Rasmussen M, Zhang Y, Mandrup OA, Salachan PV, Borre M, Sørensen KD, Howard KA.
Br J Cancer. 2022 Oct 15. doi: 10.1038/s41416-022-01994-1. Online ahead of print. PubMed
DaBlaCa-13 Study: Oncological Outcome of Short-Term, Intensive Chemoresection With Mitomycin in Nonmuscle Invasive Bladder Cancer: Primary Outcome of a Randomized Controlled Trial.
Lindgren MS, Hansen E, Azawi N, Nielsen AM, Dyrskjøt L, Jensen JB.
J Clin Oncol. 2022 Oct 12:JCO2200470. doi: 10.1200/JCO.22.00470. Online ahead of print. PubMed
Elevated T-cell Exhaustion and Urinary Tumor DNA Levels Are Associated with Bacillus Calmette-Guérin Failure in Patients with Non-muscle-invasive Bladder Cancer.
Strandgaard T, Lindskrog SV, Nordentoft I, Christensen E, Birkenkamp-Demtröder K, Andreasen TG, Lamy P, Kjær A, Ranti D, Wang YA, Bieber C, Prip F, Rasmussen J, Steiniche T, Birkbak N, Sfakianos J, Horowitz A, Jensen JB, Dyrskjøt L.
Eur Urol. 2022 Oct 6:S0302-2838(22)02636-7. doi: 10.1016/j.eururo.2022.09.008. Online ahead of print. PubMed
Recurrence rate after radical prostatectomy following primary staging of high-risk prostate cancer with 68Ga-PSMA PET/CT.
Klingenberg S, Fredsøe J, Sørensen KD, Ulhøi BP, Borre M, Jochumsen MR, Bouchelouche K.
Acta Oncol. 2022 Oct;61(10):1289-1294. doi: 10.1080/0284186X.2022.2129442. Epub 2022 Oct 5. PubMed
A transcriptional network of cell cycle dysregulation in noninvasive papillary urothelial carcinoma.
Warrick JI, Knowles MA, Hurst CD, Shuman L, Raman JD, Walter V, Putt J, Dyrskjøt L, Groeneveld C, Castro MAA, Robertson AG, DeGraff DJ.
Sci Rep. 2022 Oct 3;12(1):16538. doi: 10.1038/s41598-022-20927-9. PubMed
Predicting Grade group 2 or higher cancer at prostate biopsy by 4Kscore in blood and uCaP microRNA model in urine.
Fredsøe J, Rasmussen M, Tin AL, Vickers AJ, Borre M, Sørensen KD, Lilja H.
Sci Rep. 2022 Sep 7;12(1):15193. doi: 10.1038/s41598-022-19460-6. PubMed
Differential RNA aptamer affinity profiling on plasma as a potential diagnostic tool for bladder cancer.
Fjelstrup S, Dupont DM, Bus C, Enghild JJ, Jensen JB, Birkenkamp-Demtröder K, Dyrskjøt L, Kjems J.
NAR Cancer. 2022 Aug 22;4(3):zcac025. doi: 10.1093/narcan/zcac025. eCollection 2022 Sep. PubMed
A genome-wide CRISPR-Cas9 knockout screen identifies novel PARP inhibitor resistance genes in prostate cancer.
Ipsen, M.B., Sørensen, E.M.G., Thomsen, E.A. et al.
Oncogene. 2022 Sep;41(37):4271-4281. doi: 10.1038/s41388-022-02427-2. Epub 2022 Aug 6. PubMed
Race reporting and disparities regarding clinical trials in bladder cancer: a systematic review.
Freudenburg E, Bagheri I, Srinivas S, Martinez A, Putluri N, Klaassen Z, Kamat AM, Konety BR, Kim WY, Dyrskjøt L, McConkey DJ, Freedland SJ, Black PC, Daneshmand S, Catto JWF, Williams SB.
Cancer Causes Control. 2022 Aug;33(8):1071-1081. doi: 10.1007/s10552-022-01593-8. Epub 2022 Jun 14. PubMed
Unsupervised detection of fragment length signatures of circulating tumor DNA using non-negative matrix factorization.
Renaud G, Nørgaard M, Lindberg J, Grönberg H, De Laere B, Jensen JB, Borre M, Andersen CL, Sørensen KD, Maretty L, Besenbacher S.
Elife. 2022 Jul 27;11:e71569. doi: 10.7554/eLife.71569. PubMed
Increased Soluble PD-1 Predicts Response to Nivolumab plus Ipilimumab in Melanoma.
Pedersen JG, Sokac M, Sørensen BS, Luczak AA, Aggerholm-Pedersen N, Birkbak NJ, Øllegaard TH, Jakobsen MR.
Cancers (Basel). 2022 Jul 9;14(14):3342. doi: 10.3390/cancers14143342. PubMed
Women With Turner Syndrome Are Both Estrogen and Androgen Deficient: The Impact of Hormone Replacement Therapy.
Viuff MH, Just J, Brun S, Dam TV, Hansen M, Melgaard L, Hougaard DM, Lappe M, Gravholt CH.J Clin Endocrinol Metab. 2022 Jun 16;107(7):1983-1993. doi: 10.1210/clinem/dgac167. PubMed
Prostate Cancer Detection Rate of Manually Operated and Robot-assisted In-bore Magnetic Resonance Imaging Targeted Biopsy.
Sandahl M, Sandahl KJ, Marinovskij E, Nielsen TF, Sørensen KD, Borre M, Ulhøi BP, Pedersen BG.
Eur Urol Open Sci. 2022 May 28;41:88-94. doi: 10.1016/j.euros.2022.05.002. eCollection 2022 Jul. PubMed
Ethical Principles in the Analysis of Prostate Cancer Diagnostics.
Ebbesen M, Sørensen KD, Pedersen BG, Andersen S.
Cancer Invest. 2022 Oct;40(9):799-810. doi: 10.1080/07357907.2022.2098314. Epub 2022 Jul 24. PubMed
Treatment represents a key driver of metastatic cancer evolution.
Christensen DS, Ahrenfeldt J, Sokač M, Kisistók J, Thomsen MK, Maretty L, McGranahan N, Birkbak NJ.
Cancer Res. 2022 Jun 22:canres.CAN-22-0562-E.2022. doi: 10.1158/0008-5472.CAN-22-0562. Online ahead of print. PubMed
Characterizing molecular subtypes of high-risk non-muscle-invasive bladder cancer in African American patients.
You S, Kim M, Widen S, Yu A, Galvan GC, Choi-Kuaea Y, Eyzaguirre EJ, Dyrskjøt L, McConkey DJ, Choi W, Theodorescu D, Chan KS, Shan Y, Tyler DS, De Hoedt AM, Freedland SJ, Williams SB.
Urol Oncol. 2022 Sep;40(9):410.e19-410.e27. doi: 10.1016/j.urolonc.2022.04.013. Epub 2022 May 23.. PubMed
The changing face of Turner syndrome.
Gravholt CH, Viuff M, Just J, Sandahl K, Brun S, van der Velden J, Andersen NH, Skakkebaek A. Endocr Rev. 2022 Jun 13:bnac016. doi: 10.1210/endrev/bnac016. Epub ahead of print. PubMed
Sex chromosome aneuploidies give rise to changes in the circular RNA profile: A circular transcriptome-wide study of Turner and Klinefelter syndrome across different tissues
Johannsen EB, Just J, Viuff MH, Okholm TLH, Pedersen SB, Meyer Lauritsen K, Trolle C, Pedersen MGB, Chang S, Fedder J, Skakkebæk A, Gravholt CH. . Front Genet. 2022 Jul 22;13:928874. doi: 10.3389/fgene.2022.928874. PubMed
Circulating free testosterone and risk of aggressive prostate cancer: prospective and Mendelian randomization analyses in international consortia.
Watts EL, Perez-Cornago A, Fensom GK, Smith-Byrne K, Noor U, Andrews CD, Gunter MJ, Holmes MV, Martin RM, Tsilidis KK, Albanes D, Barricarte A, Bueno-de-Mesquita HB, Chen C, Cohn BA, Dimou NL, Ferrucci L, Flicker L, Freedman ND, Giles GG, Giovannucci EL, Goodman GE, Haiman CA, Hankey GJ, Huang J, Huang WY, Hurwitz LM, Kaaks R, Knekt P, Kubo T, Langseth H, Laughlin G, Le Marchand L, Luostarinen T, MacInnis RJ, Mäenpää HO, Männistö S, Metter EJ, Mikami K, Mucci LA, Olsen AW, Ozasa K, Palli D, Penney KL, Platz EA, Rissanen H, Sawada N, Schenk JM, Stattin P, Tamakoshi A, Thysell E, Tsai CJ, Tsugane S, Vatten L, Weiderpass E, Weinstein SJ, Wilkens LR, Yeap BB; PRACTICAL consortium, CRUK, BPC3, CAPS, PEGASUS, Allen NE, Key TJ, Travis RC.
Int J Cancer. 2022 May 17. doi: 10.1002/ijc.34116. Online ahead of print. PubMed
Independent validation of a pre-specified four-kallikrein marker model for prediction of adverse pathology and biochemical recurrence.
Rasmussen M, Fredsøe J, Tin AL, Vickers AJ, Ulhøi B, Borre M, Eastham J, Ehdaie B, Guillonneau B, Laudone V, Scardino PT, Touijer K, Sørensen KD, Lilja H.
Br J Cancer. 2022 Apr;126(7):1004-1009. doi: 10.1038/s41416-021-01661-x. Epub 2021 Dec 13. PubMed
Immune Contexture and Differentiation Features Predict Outcome in Bladder Cancer.
Taber A, Prip F, Lamy P, Agerbæk M, Jensen JB, Steiniche T, Dyrskjøt L.
Eur Urol Oncol. 2022 Apr;5(2):203-213. doi: 10.1016/j.euo.2022.01.008. Epub 2022 Feb 25. PubMed
Assessing the causal role of epigenetic clocks in the development of multiple cancers: a Mendelian randomization study.
Morales Berstein F, McCartney DL, Lu AT, Tsilidis KK, Bouras E, Haycock P, Burrows K, Phipps AI, Buchanan DD, Cheng I; PRACTICAL consortium, Martin RM, Davey Smith G, Relton CL, Horvath S, Marioni RE, Richardson TG, Richmond RC.
Elife. 2022 Mar 29;11:e75374. doi: 10.7554/eLife.75374. PubMed
Correction: Expression patterns and prognostic potential of circular RNAs in mantle cell lymphoma: a study of younger patients from the MCL2 and MCL3 clinical trials.
Dahl M, Husby S, Eskelund CW, Besenbacher S, Fjelstrup S, Côme C, Ek S, Kolstad A, Räty R, Jerkeman M, Geisler CH, Kjems J, Kristensen LS, Grønbæk K.
Leukemia. 2022 Feb 18. doi: 10.1038/s41375-022-01526-z. Online ahead of print. PubMed
Prostate cancer risk stratification improvement across multiple ancestries with new polygenic hazard score.
Huynh-Le MP, Karunamuni R, Fan CC, Asona L, Thompson WK, Martinez ME, Eeles RA, Kote-Jarai Z, Muir KR, Lophatananon A, Schleutker J, Pashayan N, Batra J, Grönberg H, Neal DE, Nordestgaard BG, Tangen CM, MacInnis RJ, Wolk A, Albanes D, Haiman CA, Travis RC, Blot WJ, Stanford JL, Mucci LA, West CML, Nielsen SF, Kibel AS, Cussenot O, Berndt SI, Koutros S, Sørensen KD, Cybulski C, Grindedal EM, Menegaux F, Park JY, Ingles SA, Maier C, Hamilton RJ, Rosenstein BS, Lu YJ, Watya S, Vega A, Kogevinas M, Wiklund F, Penney KL, Huff CD, Teixeira MR, Multigner L, Leach RJ, Brenner H, John EM, Kaneva R, Logothetis CJ, Neuhausen SL, De Ruyck K, Ost P, Razack A, Newcomb LF, Fowke JH, Gamulin M, Abraham A, Claessens F, Castelao JE, Townsend PA, Crawford DC, Petrovics G, van Schaik RHN, Parent MÉ, Hu JJ, Zheng W; UKGPCS collaborators; APCB (Australian Prostate Cancer BioResource); NC-LA PCaP Investigators; IMPACT Study Steering Committee and Collaborators; Canary PASS Investigators; Profile Study Steering Committee; PRACTICAL Consortium, Mills IG, Andreassen OA, Dale AM, Seibert TM.
Prostate Cancer Prostatic Dis. 2022 Apr;25(4):755-761. doi: 10.1038/s41391-022-00497-7. Epub 2022 Feb 12. PubMed
The transcriptional landscape and biomarker potential of circular RNAs in prostate cancer.
Hansen EB, Fredsøe J, Okholm TLH, Ulhøi BP, Klingenberg S, Jensen JB, Kjems J, Bouchelouche K, Borre M, Damgaard CK, Pedersen JS, Kristensen LS, Sørensen KD.
Genome Med. 2022 Jan 25;14(1):8. doi: 10.1186/s13073-021-01009-3. PubMed
Dysbiotic microbes and how to find them: a review of microbiome profiling in prostate cancer.
Salachan PV, Sørensen KD.
J Exp Clin Cancer Res. 2022 Jan 22;41(1):31. doi: 10.1186/s13046-021-02196-y. PubMed
Evaluation of Predictors of Biochemical Recurrence in Prostate Cancer Patients, as Detected by 68Ga-PSMA PET/CT.
Christensen MT, Jochumsen MR, Klingenberg S, Sørensen KD, Borre M, Bouchelouche K.
Diagnostics (Basel). 2022 Jan 14;12(1):195. doi: 10.3390/diagnostics12010195. PubMed
Microbiota of the prostate tumor environment investigated by whole-transcriptome profiling.
Salachan PV, Rasmussen M, Fredsøe J, Ulhøi B, Borre M, Sørensen KD.
Genome Med. 2022 Jan 25;14(1):9. doi: 10.1186/s13073-022-01011-3. PubMed
The mutationathon highlights the importance of reaching standardization in estimates of pedigree-based germline mutation rates.
Bergeron LA, Besenbacher S, Turner T, Versoza CJ, Wang RJ, Price AL, Armstrong E, Riera M, Carlson J, Chen HY, Hahn MW, Harris K, Kleppe AS, López-Nandam EH, Moorjani P, Pfeifer SP, Tiley GP, Yoder AD, Zhang G, Schierup MH.
Elife. 2022 Jan 12;11:e73577. doi: 10.7554/eLife.73577. Online ahead of print. PubMed
Expression patterns and prognostic potential of circular RNAs in mantle cell lymphoma: a study of younger patients from the MCL2 and MCL3 clinical trials.
Dahl M, Husby S, Eskelund CW, Besenbacher S, Fjelstrup S, Côme C, Ek S, Kolstad A, Räty R, Jerkeman M, Geisler CH, Kjems J, Kristensen LS, Grønbæk K.
Leukemia. 2022 Jan;36(1):177-188. doi: 10.1038/s41375-021-01311-4. Epub 2021 Jul 9. PubMed
Circulating tumor DNA for prognosis assessment and postoperative management after curative-intent resection of colorectal liver metastases.
Reinert T, Petersen LMS, Henriksen TV, Larsen MØ, Rasmussen MH, Johansen AFB, Øgaard N, Knudsen M, Nordentoft I, Vang S, Krag SRP, Knudsen AR, Mortensen FV, Lindbjerg Andersen C.
Int J Cancer. 2022 Jan 7. doi: 10.1002/ijc.33924. Online ahead of print. PubMed
2021
Stage-stratified molecular profiling of non-muscle-invasive bladder cancer enhances biological, clinical, and therapeutic insight.
Hurst CD, Cheng G, Platt FM, Castro MAA, Marzouka NS, Eriksson P, Black EVI, Alder O, Lawson ARJ, Lindskrog SV, Burns JE, Jain S, Roulson JA, Brown JC, Koster J, Robertson AG, Martincorena I, Dyrskjøt L, Höglund M, Knowles MA.
Cell Rep Med. 2021 Dec 21;2(12):100472. doi: 10.1016/j.xcrm.2021.100472. eCollection 2021 Dec 21. PubMed
SPTAN1, APC, and FGFR3 Mutation Status and APOBEC Mutation Signatures are Predictive of Mitomycin C Response in Non-muscle-invasive Bladder Cancer
Lindgren MS, Lamy P, Lindskrog SV, Christensen E, Nordentoft I, Birkenkamp-Demtröder K, Ulhøi BP, Jensen JB, Dyrskjøt L,
European Urology Open Science, Volume 34, 2021 https://doi.org/10.1016/j.euros.2021.09.018.
Corrigendum to "Identification of Differential Tumor Subtypes of T1 Bladder Cancer" [Eur. Urol. 78 (2020) 533-537].
Robertson AG, Groeneveld CS, Jordan B, Lin X, McLaughlin KA, Das A, Fall LA, Fantini D, Taxter TJ, Mogil LS, Lindskrog SV, Dyrskjøt L, McConkey DJ, Svatek RS, de Reyniès A, Castro MAA, Meeks JJ.
Eur Urol. 2021 Nov 17:S0302-2838(21)02143-6. doi: 10.1016/j.eururo.2021.11.001. Online ahead of print. PubMed
Using DNA sequencing data to quantify T cell fraction and therapy response.
Bentham R, Litchfield K, Watkins TBK, Lim EL, Rosenthal R, Martínez-Ruiz C, Hiley CT, Bakir MA, Salgado R, Moore DA, Jamal-Hanjani M; TRACERx Consortium, Swanton C, McGranahan N.
Nature. 2021 Sep;597(7877):555-560. doi: 10.1038/s41586-021-03894-5. Epub 2021 Sep 8. PubMed
Reply to: Reconciling differences in impact of molecular subtyping on response to cisplatin-based chemotherapy.
Taber A, Christensen E, Lamy P, Agerbæk M, Jensen JB, Dyrskjøt L.
Nat Commun. 2021 Aug 10;12(1):4834. doi: 10.1038/s41467-021-24839-6. PubMed
Detection and characterization of lung cancer using cell-free DNA fragmentomes.
Mathios D, Johansen JS, Cristiano S, Medina JE, Phallen J, Larsen KR, Bruhm DC, Niknafs N, Ferreira L, Adleff V, Chiao JY, Leal A, Noe M, White JR, Arun AS, Hruban C, Annapragada AV, Jensen SØ, Ørntoft MW, Madsen AH, Carvalho B, de Wit M, Carey J, Dracopoli NC, Maddala T, Fang KC, Hartman AR, Forde PM, Anagnostou V, Brahmer JR, Fijneman RJA, Nielsen HJ, Meijer GA, Andersen CL, Mellemgaard A, Bojesen SE, Scharpf RB, Velculescu VE.
Nat Commun. 2021 Aug 20;12(1):5060. doi: 10.1038/s41467-021-24994-w. PubMed
The exon-junction complex helicase eIF4A3 controls cell fate via coordinated regulation of ribosome biogenesis and translational output.
Kanellis DC, Espinoza JA, Zisi A, Sakkas E, Bartkova J, Katsori AM, Boström J, Dyrskjøt L, Broholm H, Altun M, Elsässer SJ, Lindström MS, Bartek J.
Sci Adv. 2021 Aug 4;7(32):eabf7561. doi: 10.1126/sciadv.abf7561. Print 2021 Aug. PubMed
Genome-wide Meta-analysis Identifies Novel Genes Associated with Recurrence and Progression in Non-muscle-invasive Bladder Cancer.
Galesloot TE, Grotenhuis AJ, Kolev D, Aben KK, Bryan RT, Catto JWF, Cheng KK, Conroy S, Dyrskjøt L, Fleshner NE, James ND, Lamy P, Lindskrog SV, Malats N, Mengual L, Verhaegh G, Zeegers MP, Kiemeney LALM, Vermeulen SH.
Eur Urol Oncol. 2021 Aug 2:S2588-9311(21)00120-6. doi: 10.1016/j.euo.2021.07.001. Online ahead of print. PubMed
Immune cell analyses of the tumor microenvironment in prostate cancer highlight infiltrating regulatory T cells and macrophages as adverse prognostic factors.
Andersen LB, Nørgaard M, Rasmussen M, Fredsøe J, Borre M, Ulhøi BP, Sørensen KD.
J Pathol. 2021 Oct;255(2):155-165. doi: 10.1002/path.5757. Epub 2021 Aug 10. PubMed
Expression patterns and prognostic potential of circular RNAs in mantle cell lymphoma: a study of younger patients from the MCL2 and MCL3 clinical trials.
Dahl M, Husby S, Eskelund CW, Besenbacher S, Fjelstrup S, Côme C, Ek S, Kolstad A, Räty R, Jerkeman M, Geisler CH, Kjems J, Kristensen LS, Grønbæk K.
Leukemia. 2021 Jul 9. doi: 10.1038/s41375-021-01311-4. Online ahead of print.PubMed
Discovering fragment length signatures of circulating tumor DNA using Non-negative Matrix Factorization
Renaud G, Nørgaard M, Lindberg J, Grönberg H, De Laere B, Jensen JB, Borre M, Lindbjerg C, Sørensen KD, Maretty L, Besenbacher S
doi: https://doi.org/10.1101/2021.06.09.447533
Refinement of an Established Procedure and Its Application for Identification of Hypoxia in Prostate Cancer Xenografts.
Elming PB, Wittenborn TR, Busk M, Sørensen BS, Thomsen MBH, Strandgaard T, Dyrskjøt L, Nielsen S, Horsman MR.
Cancers (Basel). 2021 May 26;13(11):2602. doi: 10.3390/cancers13112602. PubMed
Clinical Utility of Cell-free and Circulating Tumor DNA in Kidney and Bladder Cancer: A Critical Review of Current Literature.
Green EA, Li R, Albiges L, Choueiri TK, Freedman M, Pal S, Dyrskjøt L, Kamat AM.
Eur Urol Oncol. 2021 May 8:S2588-9311(21)00079-1. doi: 10.1016/j.euo.2021.04.005. Online ahead of print. PubMed
Metastatic urothelial carcinoma.
Knowles M, Dyrskjøt L, Heath EI, Bellmunt J, Siefker-Radtke AO.
Cancer Cell. 2021 May 10;39(5):583-585. doi: 10.1016/j.ccell.2021.04.012. PubMed
miRNA activity inferred from single cell mRNA expression.
Nielsen MM, et al. Sci Rep. 2021. PMID: 33911110 Free PMC article. PubMed
Risk stratification in men with a negative prostate biopsy: An interim analysis of a prospective cohort study.
Sandahl M, Pedersen BG, Ulhøi BP, Borre M, Sørensen KD.
BJU Int. 2021 Dec;128(6):702-712. doi: 10.1111/bju.15443. Epub 2021 Jun 17. PubMed
Studying mutation rate evolution in primates-a need for systematic comparison of computational pipelines.
Bergeron LA, Besenbacher S, Schierup MH, Zhang G.
Gigascience. 2021 Oct 21;10(10):giab072. doi: 10.1093/gigascience/giab072. PubMed
A polymorphism in the promoter of FRAS1 is a candidate SNP associated with metastatic prostate cancer.
Wang V, Geybels MS, Jordahl KM, Gerke T, Hamid A, Penney KL, Markt SC, Freedman M, Pomerantz M, Lee GM, Rana H, Börnigen D, Rebbeck TR, Huttenhower C, Eeles RA, Stanford JL, Consortium P, Berndt SI, Claessens F, Sørensen KD, Park JY, Vega A, Usmani N, Mucci L, Sweeney CJ.
Prostate. 2021 Jul;81(10):683-693. doi: 10.1002/pros.24148. Epub 2021 May 6. PubMed
The germline mutational process in rhesus macaque and its implications for phylogenetic dating.
Bergeron LA, Besenbacher S, Bakker J, Zheng J, Li P, Pacheco G, Sinding MS, Kamilari M, Gilbert MTP, Schierup MH, Zhang G.
Gigascience. 2021 May 5;10(5):giab029. doi: 10.1093/gigascience/giab029. PubMed
An integrated multi-omics analysis identifies prognostic molecular subtypes of non-muscle-invasive bladder cancer
Lindskrog SV, Prip F, Lamy P, Taber A, Groeneveld CS, Birkenkamp-Demtröder K, Jensen JB, Strandgaard T, Nordentoft I, Christensen E, Sokac M, Birkbak NJ, Maretty L, Hermann GG, Petersen AC, Weyerer V, Grimm MO, Horstmann M, Sjödahl G, Höglund M, Steiniche T, Mogensen K, de Reyniès A, Nawroth R, Jordan B, Lin X, Dragicevic D, Ward DG, Goel A, Hurst CD, Raman JD, Warrick JI, Segersten U, Sikic D, van Kessel KEM, Maurer T, Meeks JJ, DeGraff DJ, Bryan RT, Knowles MA, Simic T, Hartmann A, Zwarthoff EC, Malmström PU, Malats N, Real FX, Dyrskjøt L.
Nat Commun. 2021 Apr 16;12(1):2301. doi: 10.1038/s41467-021-22465-w. PubMed
NMIBC Classifier: nmibc-class.dk
A miRNA signature predicts benefit from addition of hypoxia-modifying therapy to radiation treatment in invasive bladder cancer.
Khan MT, Irlam-Jones JJ, Pereira RR, Lane B, Valentine HR, Aragaki K, Dyrskjøt L, McConkey DJ, Hoskin PJ, Choudhury A, West CML.
Br J Cancer. 2021 Apr 12. doi: 10.1038/s41416-021-01326-9. Online ahead of print. PubMed
High-Throughput and Automated Acoustic Trapping of Extracellular Vesicles to Identify microRNAs With Diagnostic Potential for Prostate Cancer.
Ku A, Fredsøe J, Sørensen KD, Borre M, Evander M, Laurell T, Lilja H, Ceder Y.
Front Oncol. 2021 Mar 25;11:631021. doi: 10.3389/fonc.2021.631021. eCollection 2021. PubMed
Targeting natural splicing plasticity of APOBEC3B restricts its expression and mutagenic activity.
Rouf Banday A, Onabajo OO, Lin SH, Obajemu A, Vargas JM, Delviks-Frankenberry KA, Lamy P, Bayanjargal A, Zettelmeyer C, Florez-Vargas O, Pathak VK, Dyrskjøt L, Prokunina-Olsson L.
Commun Biol. 2021 Mar 22;4(1):386. doi: 10.1038/s42003-021-01844-5. PubMed
STAG2 as a prognostic biomarker in low-grade non-muscle invasive bladder cancer.
Taber A, Park Y, Lelo A, Prip F, Xiao J, Berry DL, Chaldekas K, Jensen JB, Philips G, Kim JS, Harris BT, Dyrskjøt L, Waldman T.
Urol Oncol. 2021 Mar 9:S1078-1439(21)00069-7. doi: 10.1016/j.urolonc.2021.02.007. Online ahead of print. PubMed
Polygenic hazard score is associated with prostate cancer in multi-ethnic populations.
Huynh-Le MP, Fan CC, Karunamuni R, Thompson WK, Martinez ME, Eeles RA, Kote-Jarai Z, Muir K, Schleutker J, Pashayan N, Batra J, Grönberg H, Neal DE, Donovan JL, Hamdy FC, Martin RM, Nielsen SF, Nordestgaard BG, Wiklund F, Tangen CM, Giles GG, Wolk A, Albanes D, Travis RC, Blot WJ, Zheng W, Sanderson M, Stanford JL, Mucci LA, West CML, Kibel AS, Cussenot O, Berndt SI, Koutros S, Sørensen KD, Cybulski C, Grindedal EM, Menegaux F, Khaw KT, Park JY, Ingles SA, Maier C, Hamilton RJ, Thibodeau SN, Rosenstein BS, Lu YJ, Watya S, Vega A, Kogevinas M, Penney KL, Huff C, Teixeira MR, Multigner L, Leach RJ, Cannon-Albright L, Brenner H, John EM, Kaneva R, Logothetis CJ, Neuhausen SL, De Ruyck K, Pandha H, Razack A, Newcomb LF, Fowke JH, Gamulin M, Usmani N, Claessens F, Gago-Dominguez M, Townsend PA, Bush WS, Roobol MJ, Parent MÉ, Hu JJ, Mills IG, Andreassen OA, Dale AM, Seibert TM; UKGPCS collaborators; APCB (Australian Prostate Cancer BioResource); NC-LA PCaP Investigators; IMPACT Study Steering Committee and Collaborators; Canary PASS Investigators; Profile Study Steering Committee; PRACTICAL Consortium.
Nat Commun. 2021 Feb 23;12(1):1236. doi: 10.1038/s41467-021-21287-0. PubMed
Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction.
Conti DV, Darst BF, Moss LC, Saunders EJ, Sheng X, Chou A, Schumacher FR, Olama AAA, Benlloch S, Dadaev T, Brook MN, Sahimi A, Hoffmann TJ, Takahashi A, Matsuda K, Momozawa Y, Fujita M, Muir K, Lophatananon A, Wan P, Le Marchand L, Wilkens LR, Stevens VL, Gapstur SM, Carter BD, Schleutker J, Tammela TLJ, Sipeky C, Auvinen A, Giles GG, Southey MC, MacInnis RJ, Cybulski C, Wokołorczyk D, Lubiński J, Neal DE, Donovan JL, Hamdy FC, Martin RM, Nordestgaard BG, Nielsen SF, Weischer M, Bojesen SE, Røder MA, Iversen P, Batra J, Chambers S, Moya L, Horvath L, Clements JA, Tilley W, Risbridger GP, Gronberg H, Aly M, Szulkin R, Eklund M, Nordström T, Pashayan N, Dunning AM, Ghoussaini M, Travis RC, Key TJ, Riboli E, Park JY, Sellers TA, Lin HY, Albanes D, Weinstein SJ, Mucci LA, Giovannucci E, Lindstrom S, Kraft P, Hunter DJ, Penney KL, Turman C, Tangen CM, Goodman PJ, Thompson IM Jr, Hamilton RJ, Fleshner NE, Finelli A, Parent MÉ, Stanford JL, Ostrander EA, Geybels MS, Koutros S, Freeman LEB, Stampfer M, Wolk A, Håkansson N, Andriole GL, Hoover RN, Machiela MJ, Sørensen KD, Borre M, Blot WJ, Zheng W, Yeboah ED, Mensah JE, Lu YJ, Zhang HW, Feng N, Mao X, Wu Y, Zhao SC, Sun Z, Thibodeau SN, McDonnell SK, Schaid DJ, West CML, Burnet N, Barnett G, Maier C, Schnoeller T, Luedeke M, Kibel AS, Drake BF, Cussenot O, Cancel-Tassin G, Menegaux F, Truong T, Koudou YA, John EM, Grindedal EM, Maehle L, Khaw KT, Ingles SA, Stern MC, Vega A, Gómez-Caamaño A, Fachal L, Rosenstein BS, Kerns SL, Ostrer H, Teixeira MR, Paulo P, Brandão A, Watya S, Lubwama A, Bensen JT, Fontham ETH, Mohler J, Taylor JA, Kogevinas M, Llorca J, Castaño-Vinyals G, Cannon-Albright L, Teerlink CC, Huff CD, Strom SS, Multigner L, Blanchet P, Brureau L, Kaneva R, Slavov C, Mitev V, Leach RJ, Weaver B, Brenner H, Cuk K, Holleczek B, Saum KU, Klein EA, Hsing AW, Kittles RA, Murphy AB, Logothetis CJ, Kim J, Neuhausen SL, Steele L, Ding YC, Isaacs WB, Nemesure B, Hennis AJM, Carpten J, Pandha H, Michael A, De Ruyck K, De Meerleer G, Ost P, Xu J, Razack A, Lim J, Teo SH, Newcomb LF, Lin DW, Fowke JH, Neslund-Dudas C, Rybicki BA, Gamulin M, Lessel D, Kulis T, Usmani N, Singhal S, Parliament M, Claessens F, Joniau S, Van den Broeck T, Gago-Dominguez M, Castelao JE, Martinez ME, Larkin S, Townsend PA, Aukim-Hastie C, Bush WS, Aldrich MC, Crawford DC, Srivastava S, Cullen JC, Petrovics G, Casey G, Roobol MJ, Jenster G, van Schaik RHN, Hu JJ, Sanderson M, Varma R, McKean-Cowdin R, Torres M, Mancuso N, Berndt SI, Van Den Eeden SK, Easton DF, Chanock SJ, Cook MB, Wiklund F, Nakagawa H, Witte JS, Eeles RA, Kote-Jarai Z, Haiman CA.
Nat Genet. 2021 Jan;53(1):65-75. doi: 10.1038/s41588-020-00748-0. Epub 2021 Jan 4. PubMed
Additional SNPs improve risk stratification of a polygenic hazard score for prostate cancer.
Karunamuni RA, Huynh-Le MP, Fan CC, Thompson W, Eeles RA, Kote-Jarai Z, Muir K, Lophatananon A; UKGPCS collaborators, Schleutker J, Pashayan N, Batra J; APCB BioResource (Australian Prostate Cancer BioResource), Grönberg H, Walsh EI, Turner EL, Lane A, Martin RM, Neal DE, Donovan JL, Hamdy FC, Nordestgaard BG, Tangen CM, MacInnis RJ, Wolk A, Albanes D, Haiman CA, Travis RC, Stanford JL, Mucci LA, West CML, Nielsen SF, Kibel AS, Wiklund F, Cussenot O, Berndt SI, Koutros S, Sørensen KD, Cybulski C, Grindedal EM, Park JY, Ingles SA, Maier C, Hamilton RJ, Rosenstein BS, Vega A; IMPACT Study Steering Committee and Collaborators, Kogevinas M, Penney KL, Teixeira MR, Brenner H, John EM, Kaneva R, Logothetis CJ, Neuhausen SL, Razack A, Newcomb LF; Canary PASS Investigators, Gamulin M, Usmani N, Claessens F, Gago-Dominguez M, Townsend PA, Roobol MJ, Zheng W; Profile Study Steering Committee, Mills IG, Andreassen OA, Dale AM, Seibert TM; PRACTICAL Consortium.
Prostate Cancer Prostatic Dis. 2021 Jun;24(2):532-541. doi: 10.1038/s41391-020-00311-2. Epub 2021 Jan 8. PubMed
2020
Transcriptomic and proteomic intra-tumor heterogeneity of colorectal cancer varies depending on tumor location within the colorectum.
Árnadóttir SS, Mattesen TB, Vang S, Madsen MR, Madsen AH, Birkbak NJ, Bramsen JB, Andersen CL.
PLoS One. 2020 Dec 17;15(12):e0241148. doi: 10.1371/journal.pone.0241148. eCollection 2020. PubMed
Transcriptome-wide profiles of circular RNA and RNA-binding protein interactions reveal effects on circular RNA biogenesis and cancer pathway expression.
Okholm TLH, Sathe S, Park SS, Kamstrup AB, Rasmussen AM, Shankar A, Chua ZM, Fristrup N, Nielsen MM, Vang S, Dyrskjøt L, Aigner S, Damgaard CK, Yeo GW, Pedersen JS.
Genome Med. 2020 Dec 7;12(1):112. doi: 10.1186/s13073-020-00812-8. PubMed
FRMD6 has tumor suppressor functions in prostate cancer.
Haldrup J, Strand SH, Cieza-Borrella C, Jakobsson ME, Riedel M, Norgaard M, Hedensted S, Dagnaes-Hansen F, Ulhoi BP, Eeles R, Borre M, Olsen JV, Thomsen M, Kote-Jarai Z, Sorensen KD.
Oncogene. 2020 Nov 28. doi: 10.1038/s41388-020-01548-w. Online ahead of print. PubMed
The CHEK2 Variant C.349A>G Is Associated with Prostate Cancer Risk and Carriers Share a Common Ancestor.
Brandão A, Paulo P, Maia S, Pinheiro M, Peixoto A, Cardoso M, Silva MP, Santos C, Eeles RA, Kote-Jarai Z, Muir K, Ukgpcs Collaborators, Schleutker J, Wang Y, Pashayan N, Batra J, Apcb BioResource, Grönberg H, Neal DE, Nordestgaard BG, Tangen CM, Southey MC, Wolk A, Albanes D, Haiman CA, Travis RC, Stanford JL, Mucci LA, West CML, Nielsen SF, Kibel AS, Cussenot O, Berndt SI, Koutros S, Sørensen KD, Cybulski C, Grindedal EM, Park JY, Ingles SA, Maier C, Hamilton RJ, Rosenstein BS, Vega A, The Impact Study Steering Committee And Collaborators, Kogevinas M, Wiklund F, Penney KL, Brenner H, John EM, Kaneva R, Logothetis CJ, Neuhausen SL, Ruyck K, Razack A, Newcomb LF, Canary Pass Investigators, Lessel D, Usmani N, Claessens F, Gago-Dominguez M, Townsend PA, Roobol MJ, The Profile Study Steering Committee, The Practical Consortium, Teixeira MR.
Cancers (Basel). 2020 Nov 4;12(11):E3254. doi: 10.3390/cancers12113254. PubMed
Molecular correlates of cisplatin-based chemotherapy response in muscle invasive bladder cancer by integrated multi-omics analysis.
Taber A, Christensen E, Lamy P, Nordentoft I, Prip F, Lindskrog SV, Birkenkamp-Demtröder K, Okholm TLH, Knudsen M, Pedersen JS, Steiniche T, Agerbæk M, Jensen JB, Dyrskjøt L.
Nat Commun. 2020 Sep 25;11(1):4858. doi: 10.1038/s41467-020-18640-0. PubMed
African-specific improvement of a polygenic hazard score for age at diagnosis of prostate cancer.
Karunamuni RA, Huynh-Le MP, Fan CC, Thompson W, Eeles RA, Kote-Jarai Z, Muir K; UKGPCS collaborators, Lophatananon A, Tangen CM, Goodman PJ, Thompson IM Jr, Blot WJ, Zheng W, Kibel AS, Drake BF, Cussenot O, Cancel-Tassin G, Menegaux F, Truong T, Park JY, Lin HY, Bensen JT, Fontham ETH, Mohler JL, Taylor JA, Multigner L, Blanchet P, Brureau L, Romana M, Leach RJ, John EM, Fowke J, Bush WS, Aldrich M, Crawford DC, Srivastava S, Cullen JC, Petrovics G, Parent MÉ, Hu JJ, Sanderson M, Mills IG, Andreassen OA, Dale AM, Seibert TM; PRACTICAL Consortium.
Int J Cancer. 2020 Sep 15. doi: 10.1002/ijc.33282. Online ahead of print. PubMed
Pervasive chromosomal instability and karyotype order in tumour evolution.
Watkins TBK, Lim EL, Petkovic M, Elizalde S, Birkbak NJ, Wilson GA, Moore DA, Grönroos E, Rowan A, Dewhurst SM, Demeulemeester J, Dentro SC, Horswell S, Au L, Haase K, Escudero M, Rosenthal R, Bakir MA, Xu H, Litchfield K, Lu WT, Mourikis TP, Dietzen M, Spain L, Cresswell GD, Biswas D, Lamy P, Nordentoft I, Harbst K, Castro-Giner F, Yates LR, Caramia F, Jaulin F, Vicier C, Tomlinson IPM, Brastianos PK, Cho RJ, Bastian BC, Dyrskjøt L, Jönsson GB, Savas P, Loi S, Campbell PJ, Andre F, Luscombe NM, Steeghs N, Tjan-Heijnen VCG, Szallasi Z, Turajlic S, Jamal-Hanjani M, Van Loo P, Bakhoum SF, Schwarz RF, McGranahan N, Swanton C.
Nature. 2020 Sep 2. doi: 10.1038/s41586-020-2698-6. Online ahead of print. PubMed
A Nordic initiative for a more personal and accurate diagnostic pathway for prostate cancer.
Kjosavik SR, Sørensen KD, Hotakainen K, Grönberg H.
Scand J Prim Health Care. 2020 Sep;38(3):249-250. doi: 10.1080/02813432.2020.1801148. PubMed
Autophagy role(s) in response to oncogenes and DNA replication stress.
Vanzo R, Bartkova J, Merchut-Maya JM, Hall A, Bouchal J, Dyrskjøt L, Frankel LB, Gorgoulis V, Maya-Mendoza A, Jäättelä M, Bartek J.
Cell Death Differ. 2020 Mar;27(3):1134-1153. doi: 10.1038/s41418-019-0403-9. Epub 2019 Aug 14. PubMed
An integrative multi-omics analysis to identify candidate DNA methylation biomarkers related to prostate cancer risk.
Wu L, Yang Y, Guo X, Shu XO, Cai Q, Shu X, Li B, Tao R, Wu C, Nikas JB, Sun Y, Zhu J, Roobol MJ, Giles GG, Brenner H, John EM, Clements J, Grindedal EM, Park JY, Stanford JL, Kote-Jarai Z, Haiman CA, Eeles RA, Zheng W, Long J; PRACTICAL consortium; CRUK Consortium; BPC3 Consortium; CAPS Consortium; PEGASUS Consortium.
Nat Commun. 2020 Aug 6;11(1):3905. doi: 10.1038/s41467-020-17673-9. PubMed
The DaBlaCa-13 Study: Short-term, Intensive Chemoresection Versus Standard Adjuvant Intravesical Instillations in Non-muscle-invasive Bladder Cancer-A Randomised Controlled Trial.
Lindgren MS, Bue P, Azawi N, Blichert-Refsgaard L, Sundelin MO, Dyrskjøt L, Jensen JB.
Eur Urol. 2020 Dec;78(6):856-862. doi: 10.1016/j.eururo.2020.07.009. Epub 2020 Jul 28. PubMed
Validation of the four-miRNA biomarker panel MiCaP for prediction of long-term prostate cancer outcome.
Strand SH, Schmidt L, Weiss S, Borre M, Kristensen H, Rasmussen AKI, Daugaard TF, Kristensen G, Stroomberg HV, Røder MA, Brasso K, Mouritzen P, Sørensen KD.
Sci Rep. 2020 Jul 1;10(1):10704. doi: 10.1038/s41598-020-67320-y. PubMed
Predicting response to cancer immunotherapy using noninvasive radiomic biomarkers.
Trebeschi S, Drago SG, Birkbak NJ, Kurilova I, Cǎlin AM, Delli Pizzi A, Lalezari F, Lambregts DMJ, Rohaan MW, Parmar C, Rozeman EA, Hartemink KJ, Swanton C, Haanen JBAG, Blank CU, Smit EF, Beets-Tan RGH, Aerts HJWL.
Ann Oncol. 2019 Jun 1;30(6):998-1004. doi: 10.1093/annonc/mdz108. PubMed
Epigenetic Analysis of Circulating Tumor DNA in Localized and Metastatic Prostate Cancer: Evaluation of Clinical Biomarker Potential.
Bjerre MT, Nørgaard M, Larsen OH, Jensen SØ, Strand SH, Østergren P, Fode M, Fredsøe J, Ulhøi BP, Mortensen MM, Jensen JB, Borre M, Sørensen KD.
Cells. 2020 May 31;9(6). pii: E1362. doi: 10.3390/cells9061362. PubMed
The effect of surgical trauma on circulating free DNA levels in cancer patients - implications for studies of circulating tumor DNA.
Henriksen TV, Reinert T, Christensen E, Sethi H, Birkenkamp-Demtröder K, Gögenur M, Gögenur I, Zimmermann BG; IMPROVE study group, Dyrskjøt L, Andersen CL.
Mol Oncol. 2020 Aug;14(8):1670-1679. doi: 10.1002/1878-0261.12729. Epub 2020 Jun 16. PubMed
Epigenetic and transcriptomic consequences of excess X-chromosome material in 47,XXX syndrome-A comparison with Turner syndrome and 46,XX females.
Nielsen MM, Trolle C, Vang S, Hornshøj H, Skakkebaek A, Hedegaard J, Nordentoft I, Pedersen JS, Gravholt CH.
Am J Med Genet C Semin Med Genet. 2020 Jun 3. doi: 10.1002/ajmg.c.31799. Online ahead of print. PubMed
Epigenetics and genomics in Klinefelter syndrome.
Skakkebaek A, Viuff M, Nielsen MM, Gravholt CH.
Am J Med Genet C Semin Med Genet. 2020 Jun 2. doi: 10.1002/ajmg.c.31802. Online ahead of print. PubMed
Morbidity in 47,XYY syndrome: a nationwide epidemiological study of hospital diagnoses and medication use.
Berglund A, Stochholm K, Gravholt CH.
Genet Med. 2020 Jun 1. doi: 10.1038/s41436-020-0837-y. Online ahead of print. PubMed
Enhanced Performance of DNA Methylation Markers by Simultaneous Measurement of Sense and Antisense DNA Strands after Cytosine Conversion
Sarah Ø Jensen, Nadia Øgaard, Hans Jørgen Nielsen, Jesper B Bramsen, Claus L Andersen
Clinical Chemistry, , hvaa100, https://doi.org/10.1093/clinchem/hvaa100 PubMed
Psychological functioning, brain morphology, and functional neuroimaging in Klinefelter syndrome.
Skakkebaek A, Gravholt CH, Chang S, Moore PJ, Wallentin M.
Am J Med Genet C Semin Med Genet. 2020 May 28. doi: 10.1002/ajmg.c.31806. Online ahead of print. PubMed
Geospatial immune variability illuminates differential evolution of lung adenocarcinoma.
AbdulJabbar K, Raza SEA, Rosenthal R, Jamal-Hanjani M, Veeriah S, Akarca A, Lund T, Moore DA, Salgado R, Al Bakir M, Zapata L, Hiley CT, Officer L, Sereno M, Smith CR, Loi S, Hackshaw A, Marafioti T, Quezada SA, McGranahan N, Le Quesne J; TRACERx Consortium, Swanton C, Yuan Y.
Nat Med. 2020 Jul;26(7):1054-1062. doi: 10.1038/s41591-020-0900-x. Epub 2020 May 27. PubMed
A genetic risk assessment for prostate cancer influences patients' risk perception and use of repeat PSA testing: a cross-sectional study in Danish general practice.
Fredsøe J, Kirkegaard P, Edwards A, Vedsted P, Sørensen KD, Bro F.
BJGP Open. 2020 May 26. pii: bjgpopen20X101039. doi: 10.3399/bjgpopen20X101039. [Epub ahead of print] PubMed
Genomic analysis of male puberty timing highlights shared genetic basis with hair colour and lifespan.
Hollis B, Day FR, Busch AS, Thompson DJ, Soares ALG, Timmers PRHJ, Kwong A, Easton DF, Joshi PK, Timpson NJ; PRACTICAL Consortium; 23andMe Research Team, Ong KK, Perry JRB.
Nat Commun. 2020 Mar 24;11(1):1536. doi: 10.1038/s41467-020-14451-5. PubMed
68Ga-PSMA PET/CT for primary NM staging of high-risk prostate cancer.
Klingenberg S, Jochumsen MR, Ulhøi BP, Fredsøe J, Sørensen KD, Borre M, Bouchelouche K.
J Nucl Med. 2020 May 22. pii: jnumed.120.245605. doi: 10.2967/jnumed.120.245605. [Epub ahead of print] PubMed
Representative Sequencing: Unbiased Sampling of Solid Tumor Tissue.
Litchfield K, Stanislaw S, Spain L, Gallegos LL, Rowan A, Schnidrig D, Rosenbaum H, Harle A, Au L, Hill SM, Tippu Z, Thomas J, Thompson L, Xu H, Horswell S, Barhoumi A, Jones C, Leith KF, Burgess DL, Watkins TBK, Lim E, Birkbak NJ, Lamy P, Nordentoft I, Dyrskjøt L, Pickering L, Hazell S, Jamal-Hanjani M; PEACE Consortium, Larkin J, Swanton C, Alexander NR, Turajlic S.
Cell Rep. 2020 May 5;31(5):107550. doi: 10.1016/j.celrep.2020.107550. PubMed
What microRNAs could tell us about the human X chromosome.
Di Palo A, Siniscalchi C, Salerno M, Russo A, Gravholt CH, Potenza N.
Cell Mol Life Sci. 2020 Apr 30. doi: 10.1007/s00018-020-03526-7. [Epub ahead of print] Review. PubMed
Genomic heterogeneity in bladder cancer: challenges and possible solutions to improve outcomes.
Meeks JJ, Al-Ahmadie H, Faltas BM, Taylor JA 3rd, Flaig TW, DeGraff DJ, Christensen E, Woolbright BL, McConkey DJ, Dyrskjøt L.
Nat Rev Urol. 2020 May;17(5):259-270. doi: 10.1038/s41585-020-0304-1. Epub 2020 Mar 31. PubMed
Profiling of Circulating microRNAs in Prostate Cancer Reveals Diagnostic Biomarker Potential.
Fredsøe J, Rasmussen AKI, Mouritzen P, Bjerre MT, Østergren P, Fode M, Borre M, Sørensen KD.
Diagnostics (Basel). 2020 Mar 28;10(4). pii: E188. doi: 10.3390/diagnostics10040188. PubMed
Converging Roads to Early Bladder Cancer.
Necchi A, Gallina A, Dyrskjøt L, Roupret M, Kamat AM, Spiess PE, Grivas P, Gibb EA, Briganti A, Montorsi F.
Eur Urol. 2020 Aug;78(2):127-130. doi: 10.1016/j.eururo.2020.02.031. Epub 2020 Mar 17. PubMed
Interplay between whole-genome doubling and the accumulation of deleterious alterations in cancer evolution.
López S, Lim EL, Horswell S, Haase K, Huebner A, Dietzen M, Mourikis TP, Watkins TBK, Rowan A, Dewhurst SM, Birkbak NJ, Wilson GA, Van Loo P, Jamal-Hanjani M; TRACERx Consortium, Swanton C, McGranahan N.
Nat Genet. 2020 Mar;52(3):283-293. doi: 10.1038/s41588-020-0584-7. Epub 2020 Mar 5. PubMed
FcRn overexpression in human cancer drives albumin recycling and cell growth; a mechanistic basis for exploitation in targeted albumin-drug designs.
Larsen MT, Mandrup OA, Schelde KK, Luo Y, Sørensen KD, Dagnæs-Hansen F, Cameron J, Stougaard M, Steiniche T, Howard KA.
J Control Release. 2020 Mar 4. pii: S0168-3659(20)30151-6. doi: 10.1016/j.jconrel.2020.03.004. [Epub ahead of print] PubMed
Combined burden and functional impact tests for cancer driver discovery using DriverPower.
Shuai S; PCAWG Drivers and Functional Interpretation Working Group, Gallinger S, Stein L; PCAWG Consortium.
Nat Commun. 2020 Feb 5;11(1):734. doi: 10.1038/s41467-019-13929-1. PubMed
The effect of assessing genetic risk of prostate cancer on the use of PSA tests in primary care: A cluster randomized controlled trial.
Fredsøe J, Koetsenruyter J, Vedsted P, Kirkegaard P, Væth M, Edwards A, Ørntoft TF, Sørensen KD, Bro F.
PLoS Med. 2020 Feb 7;17(2):e1003033. doi: 10.1371/journal.pmed.1003033. eCollection 2020 Feb. PubMed
Reply To Kenneth B. Yatai, Mark J. Dunning, Dennis Wang. Consensus Genomic Subtypes of Muscle-invasive Bladder Cancer: A Step in the Right Direction but Still a Long Way To Go. Eur Urol. In press.
Kamoun A, de Reyniès A, Allory Y, Sjödahl G, Robertson AG, Seiler R, Hoadley KA, Groeneveld CS, Al-Ahmadie H, Choi W, Castro MAA, Fontugne J, Eriksson P, Mo Q, Kardos J, Zlotta A, Hartmann A, Dinney CP, Bellmunt J, Powles T, Malats N, Chan KS, Kim WY, McConkey DJ, Black PC, Dyrskjøt L, Höglund M, Lerner SP, Real FX, Radvanyi F, Aine M, Bernard-Pierrot I, Czerniak B, Gibb EA, Kim J, Kwiatkowski DJ, Lebret T, Liedberg F, Siefker-Radtke AA, Sirab N, Taber A, Weinstein JN.
Eur Urol. 2020 Feb 6. pii: S0302-2838(19)30958-3. doi: 10.1016/j.eururo.2019.12.014. [Epub ahead of print] No abstract available. PubMed
Analyses of non-coding somatic drivers in 2,658 cancer whole genomes.
Rheinbay E, Nielsen MM, Abascal F, Wala JA, Shapira O, Tiao G, Hornshøj H, Hess JM, Juul RI, Lin Z, Feuerbach L, Sabarinathan R, Madsen T, Kim J, Mularoni L, Shuai S, Lanzós A, Herrmann C, Maruvka YE, Shen C, Amin SB, Bandopadhayay P, Bertl J, Boroevich KA, Busanovich J, Carlevaro-Fita J, Chakravarty D, Chan CWY, Craft D, Dhingra P, Diamanti K, Fonseca NA, Gonzalez-Perez A, Guo Q, Hamilton MP, Haradhvala NJ, Hong C, Isaev K, Johnson TA, Juul M, Kahles A, Kahraman A, Kim Y, Komorowski J, Kumar K, Kumar S, Lee D, Lehmann KV, Li Y, Liu EM, Lochovsky L, Park K, Pich O, Roberts ND, Saksena G, Schumacher SE, Sidiropoulos N, Sieverling L, Sinnott-Armstrong N, Stewart C, Tamborero D, Tubio JMC, Umer HM, Uusküla-Reimand L, Wadelius C, Wadi L, Yao X, Zhang CZ, Zhang J, Haber JE, Hobolth A, Imielinski M, Kellis M, Lawrence MS, von Mering C, Nakagawa H, Raphael BJ, Rubin MA, Sander C, Stein LD, Stuart JM, Tsunoda T, Wheeler DA, Johnson R, Reimand J, Gerstein M, Khurana E, Campbell PJ, López-Bigas N; PCAWG Drivers and Functional Interpretation Working Group; PCAWG Structural Variation Working Group, Weischenfeldt J, Beroukhim R, Martincorena I, Pedersen JS, Getz G; PCAWG Consortium.
Nature. 2020 Feb;578(7793):102-111. doi: 10.1038/s41586-020-1965-x. Epub 2020 Feb 5. PubMed
Cancer LncRNA Census reveals evidence for deep functional conservation of long noncoding RNAs in tumorigenesis.
Carlevaro-Fita J, Lanzós A, Feuerbach L, Hong C, Mas-Ponte D, Pedersen JS; PCAWG Drivers and Functional Interpretation Group, Johnson R; PCAWG Consortium.
Commun Biol. 2020 Feb 5;3(1):56. doi: 10.1038/s42003-019-0741-7. PubMed
Pathway and network analysis of more than 2500 whole cancer genomes.
Reyna MA, Haan D, Paczkowska M, Verbeke LPC, Vazquez M, Kahraman A, Pulido-Tamayo S, Barenboim J, Wadi L, Dhingra P, Shrestha R, Getz G, Lawrence MS, Pedersen JS, Rubin MA, Wheeler DA, Brunak S, Izarzugaza JMG, Khurana E, Marchal K, von Mering C, Sahinalp SC, Valencia A; PCAWG Drivers and Functional Interpretation Working Group, Reimand J, Stuart JM, Raphael BJ; PCAWG Consortium.
Nat Commun. 2020 Feb 5;11(1):729. doi: 10.1038/s41467-020-14367-0. PubMed
Sex Hormone Replacement Therapy in Turner Syndrome: Impact on Morbidity and Mortality.
Viuff MH, Berglund A, Juul S, Andersen NH, Stochholm K, Gravholt CH.
J Clin Endocrinol Metab. 2020 Feb 1;105(2). pii: dgz039. doi: 10.1210/clinem/dgz039. PubMed
Klinefelter syndrome and testosterone treatment: a national cohort study on thrombosis risk.
Chang S, Christiansen CF, Bojesen A, Juul S, Münster AB, Gravholt CH.
Endocr Connect. 2020 Jan;9(1):34-43. doi: 10.1530/EC-19-0433. PubMed
IMPROVE-IT2: implementing noninvasive circulating tumor DNA analysis to optimize the operative and postoperative treatment for patients with colorectal cancer - intervention trial 2. Study protocol.
Nors J, Henriksen TV, Gotschalck KA, Juul T, Søgaard J, Iversen LH, Andersen CL.
Acta Oncol. 2020 Mar;59(3):336-341. doi: 10.1080/0284186X.2019.1711170. Epub 2020 Jan 10. PubMed
Cancer Genome Evolutionary Trajectories in Metastasis.
Birkbak NJ, McGranahan N.
Cancer Cell. 2020 Jan 13;37(1):8-19. doi: 10.1016/j.ccell.2019.12.004. Review. PubMed
2019
Eur Urol. 2019 Nov 28. pii: S0302-2838(19)30874-7. doi: 10.1016/j.eururo.2019.11.011. [Epub ahead of print] No abstract available. PubMed
Clin Epigenetics. 2019 Oct 22;11(1):147. doi: 10.1186/s13148-019-0742-x. PubMed
Nat Med. 2019 Oct 7. doi: 10.1038/s41591-019-0595-z. [Epub ahead of print] PubMed
Nat Med. 2019 Oct 4. doi: 10.1038/s41591-019-0592-2. [Epub ahead of print] PubMed
Int J Mol Sci. 2019 Sep 26;20(19). pii: E4775. doi: 10.3390/ijms20194775.
PMID: 31561442 [PubMed - in process] Free Article PubMed
Eur Urol. 2019 Sep 25. pii: S0302-2838(19)30695-5. doi: 10.1016/j.eururo.2019.09.006. [Epub ahead of print]
PMID: 31563503 [PubMed - as supplied by publisher] Free Article PubMed
Nat Commun. 2019 Sep 23;10(1):4386. doi: 10.1038/s41467-019-12095-8. PubMed
Am J Pathol. 2019 Dec;189(12):2377-2388. doi: 10.1016/j.ajpath.2019.08.007. Epub 2019 Sep 17. PubMed
Eur Urol. 2019 Sep 4. pii: S0302-2838(19)30656-6. doi: 10.1016/j.eururo.2019.08.012. [Epub ahead of print] No abstract available. PubMed
Cancer Inform. 2019 Aug 30;18:1176935119872163. doi: 10.1177/1176935119872163. eCollection 2019. PubMed
Autophagy role(s) in response to oncogenes and DNA replication stress.
Vanzo R, Bartkova J, Merchut-Maya JM, Hall A, Bouchal J, Dyrskjøt L, Frankel LB, Gorgoulis V, Maya-Mendoza A, Jäättelä M, Bartek J.
Cell Death Differ. 2019 Aug 14. doi: 10.1038/s41418-019-0403-9. [Epub ahead of print] PubMed
Correlation between early dynamics in circulating tumour DNA and outcome from FOLFIRI treatment in metastatic colorectal cancer
Lyskjær I, Kronborg CS, Rasmussen MH, Sørensen BS, Demuth C, Rosenkilde M, Johansen AFB, Knudsen M, Vang S, Krag SRP, Spindler KG, Andersen CL
Scientific Reports (2019) 9:11542, doi: 10.1038/s41598-019-47708-1 Open Access
Association Mapping and Disease: Evolutionary Perspectives.
Besenbacher S, Mailund T, Vilhjálmsson BJ, Schierup MH.
Methods Mol Biol. 2019;1910:533-553. doi: 10.1007/978-1-4939-9074-0_17. PubMed
Turner syndrome: mechanisms and management
Gravholt CH, Viuff MH, Brun S, Stochholm K, Andersen NH
Nature Reviews Endocrinology 2019, June 18. doi: 10.1038/ s41574-019-0224-4
Genome-wide cell-free DNA fragmentation in patients with cancer.
Cristiano S, Leal A, Phallen J, Fiksel J, Adleff V, Bruhm DC, Jensen SØ, Medina JE, Hruban C, White JR, Palsgrove DN, Niknafs N, Anagnostou V, Forde P, Naidoo J, Marrone K, Brahmer J, Woodward BD, Husain H, van Rooijen KL, Ørntoft MW, Madsen AH, van de Velde CJH, Verheij M, Cats A, Punt CJA, Vink GR, van Grieken NCT, Koopman M, Fijneman RJA, Johansen JS, Nielsen HJ, Meijer GA, Andersen CL, Scharpf RB, Velculescu VE.
Nature. 2019 May 29. doi: 10.1038/s41586-019-1272-6. [Epub ahead of print] PubMed
Association analyses identify 31 new risk loci for colorectal cancer susceptibility.
Law PJ, Timofeeva M, Fernandez-Rozadilla C, Broderick P, Studd J, Fernandez-Tajes J, Farrington S, Svinti V, Palles C, Orlando G, Sud A, Holroyd A, Penegar S, Theodoratou E, Vaughan-Shaw P, Campbell H, Zgaga L, Hayward C, Campbell A, Harris S, Deary IJ, Starr J, Gatcombe L, Pinna M, Briggs S, Martin L, Jaeger E, Sharma-Oates A, East J, Leedham S, Arnold R, Johnstone E, Wang H, Kerr D, Kerr R, Maughan T, Kaplan R, Al-Tassan N, Palin K, Hänninen UA, Cajuso T, Tanskanen T, Kondelin J, Kaasinen E, Sarin AP, Eriksson JG, Rissanen H, Knekt P, Pukkala E, Jousilahti P, Salomaa V, Ripatti S, Palotie A, Renkonen-Sinisalo L, Lepistö A, Böhm J, Mecklin JP, Buchanan DD, Win AK, Hopper J, Jenkins ME, Lindor NM, Newcomb PA, Gallinger S, Duggan D, Casey G, Hoffmann P, Nöthen MM, Jöckel KH, Easton DF, Pharoah PDP, Peto J, Canzian F, Swerdlow A, Eeles RA, Kote-Jarai Z, Muir K, Pashayan N; PRACTICAL consortium, Harkin A, Allan K, McQueen J, Paul J, Iveson T, Saunders M, Butterbach K, Chang-Claude J, Hoffmeister M, Brenner H, Kirac I, Matošević P, Hofer P, Brezina S, Gsur A, Cheadle JP, Aaltonen LA, Tomlinson I, Houlston RS, Dunlop MG.
Nat Commun. 2019 May 14;10(1):2154. doi: 10.1038/s41467-019-09775-w. PubMed
Analysis of Plasma Cell-Free DNA by Ultradeep Sequencing in Patients With Stages I to III Colorectal Cancer.
Reinert T, Henriksen TV, Christensen E, Sharma S, Salari R, Sethi H, Knudsen M, Nordentoft I, Wu HT, Tin AS, Heilskov Rasmussen M, Vang S, Shchegrova S, Frydendahl Boll Johansen A, Srinivasan R, Assaf Z, Balcioglu M, Olson A, Dashner S, Hafez D, Navarro S, Goel S, Rabinowitz M, Billings P, Sigurjonsson S, Dyrskjøt L, Swenerton R, Aleshin A, Laurberg S, Husted Madsen A, Kannerup AS, Stribolt K, Palmelund Krag S, Iversen LH, Gotschalck Sunesen K, Lin CJ, Zimmermann BG, Lindbjerg Andersen C.
JAMA Oncol. 2019 May 9. doi: 10.1001/jamaoncol.2019.0528. [Epub ahead of print] PubMed
Early Detection of Metastatic Relapse and Monitoring of Therapeutic Efficacy by Ultra-Deep Sequencing of Plasma Cell-Free DNA in Patients With Urothelial Bladder Carcinoma.
Christensen E, Birkenkamp-Demtröder K, Sethi H, Shchegrova S, Salari R, Nordentoft I, Wu HT, Knudsen M, Lamy P, Lindskrog SV, Taber A, Balcioglu M, Vang S, Assaf Z, Sharma S, Tin AS, Srinivasan R, Hafez D, Reinert T, Navarro S, Olson A, Ram R, Dashner S, Rabinowitz M, Billings P, Sigurjonsson S, Andersen CL, Swenerton R, Aleshin A, Zimmermann B, Agerbæk M, Lin CJ, Jensen JB, Dyrskjøt L.
J Clin Oncol. 2019 May 6:JCO1802052. doi: 10.1200/JCO.18.02052. [Epub ahead of print] PubMed
Identification of ADAM12 as a Novel Basigin Sheddase.
Albrechtsen R, Wewer Albrechtsen NJ, Gnosa S, Schwarz J, Dyrskjøt L, Kveiborg M.
Int J Mol Sci. 2019 Apr 22;20(8). pii: E1957. doi: 10.3390/ijms20081957. PubMed
APOBEC-mediated Mutagenesis as a Likely Cause of FGFR3 S249C Mutation Over-representation in Bladder Cancer.
Shi MJ, Meng XY, Lamy P, Banday AR, Yang J, Moreno-Vega A, Chen CL, Dyrskjøt L, Bernard-Pierrot I, Prokunina-Olsson L, Radvanyi F.
Eur Urol. 2019 Jul;76(1):9-13. doi: 10.1016/j.eururo.2019.03.032. Epub 2019 Apr 8. PubMed
A five-microRNA model (pCaP) for predicting prostate cancer aggressiveness using cell-free urine.
Fredsøe J, Rasmussen AKI, Mouritzen P, Borre M, Ørntoft T, Sørensen KD.
Int J Cancer. 2019 Mar 23. doi: 10.1002/ijc.32296. [Epub ahead of print] PubMed
Predicting Response to Cancer Immunotherapy using Non-invasive Radiomic Biomarkers.
Trebeschi S, Drago SG, Birkbak NJ, Kurilova I, Cǎlin AM, Pizzi AD, Lalezari F, Lambregts DMJ, Rohaan M, Parmar C, Hartemink KJ, Swanton C, Haanen JBAG, Blank CU, Smit EF, Beets-Tan RGH, Aerts HJWL.
Ann Oncol. 2019 Mar 21. pii: mdz108. doi: 10.1093/annonc/mdz108. [Epub ahead of print] PubMed
Neoantigen-directed immune escape in lung cancer evolution.
Rosenthal R, Cadieux EL, Salgado R, Bakir MA, Moore DA, Hiley CT, Lund T, Tanić M, Reading JL, Joshi K, Henry JY, Ghorani E, Wilson GA, Birkbak NJ, Jamal-Hanjani M, Veeriah S, Szallasi Z, Loi S, Hellmann MD, Feber A, Chain B, Herrero J, Quezada SA, Demeulemeester J, Van Loo P, Beck S, McGranahan N, Swanton C; TRACERx consortium.
Nature. 2019 Mar;567(7749):479-485. doi: 10.1038/s41586-019-1032-7. Epub 2019 Mar 20. PubMed
Aberrant DOCK2, GRASP, HIF3A and PKFP Hypermethylation has Potential as a Prognostic Biomarker for Prostate Cancer.
Bjerre MT, Strand SH, Nørgaard M, Kristensen H, Rasmussen AK, Mortensen MM, Fredsøe J, Mouritzen P, Ulhøi B, Ørntoft T, Borre M, Sørensen KD.
Int J Mol Sci. 2019 Mar 7;20(5). pii: E1173. doi: 10.3390/ijms20051173. PubMed
Androgen Receptor mRNA Expression in Urothelial Carcinoma of the Bladder: A Retrospective Analysis of Two Independent Cohorts.
Sikic D, Wirtz RM, Wach S, Dyrskjøt L, Erben P, Bolenz C, Breyer J, Otto W, Hoadley KA, Lerner SP, Eckstein M, Hartmann A, Keck B.
Transl Oncol. 2019 Apr;12(4):661-668. doi: 10.1016/j.tranon.2019.01.005. Epub 2019 Mar PubMed
21-hydroxylase autoantibodies are more prevalent in Turner syndrome but without an association to the autoimmune polyendocrine syndrome type I.
Berglund A, Cleemann L, Oftedal BE, Holm K, Husebye ES, Gravholt CH.
Clin Exp Immunol. 2019 Mar;195(3):364-368. doi: 10.1111/cei.13231. Epub 2018 Nov 14. PubMed
Large-scale genomic comparison of UTUC and bladder tumours.
Dyrskjøt L.
Nat Rev Urol. 2019 Mar;16(3):149-150. doi: 10.1038/s41585-019-0145-y. No abstract available. PubMed
Survival and Long-Term Biochemical Cure in Medullary Thyroid Carcinoma in Denmark 1997-2014: A Nationwide Study.
Mathiesen JS, Kroustrup JP, Vestergaard P, Stochholm K, Poulsen PL, Rasmussen ÅK, Feldt-Rasmussen U, Schytte S, Londero SC, Pedersen HB, Hahn CH, Bentzen J, Möller S, Gaustadnes M, Rossing M, Nielsen FC, Brixen K, Frederiksen AL, Godballe C.
Thyroid. 2019 Mar;29(3):368-377. doi: 10.1089/thy.2018.0564. Epub 2019 Jan 31. PubMed
Artificial intelligence in cancer imaging: Clinical challenges and applications.
Bi WL, Hosny A, Schabath MB, Giger ML, Birkbak NJ, Mehrtash A, Allison T, Arnaout O, Abbosh C, Dunn IF, Mak RH, Tamimi RM, Tempany CM, Swanton C, Hoffmann U, Schwartz LH, Gillies RJ, Huang RY, Aerts HJWL.
CA Cancer J Clin. 2019 Mar;69(2):127-157. doi: 10.3322/caac.21552. Epub 2019 Feb 5. Review. PubMed
Molecular Subtypes of Bladder Cancer: Academic Exercise or Clinical Relevance?
Dyrskjøt L.
Eur Urol. 2019 Mar;75(3):433-434. doi: 10.1016/j.eururo.2018.09.006. Epub 2018 Sep 17. No abstract available. PubMed
Epigenetics and genomics in Turner syndrome.
Viuff M, Skakkebaek A, Nielsen MM, Chang S, Gravholt CH.
Am J Med Genet C Semin Med Genet. 2019 Mar;181(1):68-75. doi: 10.1002/ajmg.c.31683. Epub 2019 Feb 27. Review. PubMed
5hmC Level Predicts Biochemical Failure Following Radical Prostatectomy in Prostate Cancer Patients with ERG Negative Tumors.
Kristensen G, Strand SH, Røder MA, Berg KD, Toft BG, Høyer S, Borre M, Sørensen KD, Brasso K.
Int J Mol Sci. 2019 Feb 27;20(5). pii: E1025. doi: 10.3390/ijms20051025. PubMed
Independent Validation of a Diagnostic Noninvasive 3-MicroRNA Ratio Model uCaP for Prostate Cancer in Cell-Free Urine.
Fredsøe J, Rasmussen AKI, Laursen EB, Cai Y, Howard KA, Pedersen BG, Borre M, Mouritzen P, Òrntoft T, Sørensen KD.
Clin Chem. 2019 Apr;65(4):540-548. doi: 10.1373/clinchem.2018.296681. Epub 2019 Feb 6. PubMed
Artificial intelligence in cancer imaging: Clinical challenges and applications.
Bi WL, Hosny A, Schabath MB, Giger ML, Birkbak NJ, Mehrtash A, Allison T, Arnaout O, Abbosh C, Dunn IF, Mak RH, Tamimi RM, Tempany CM, Swanton C, Hoffmann U, Schwartz LH, Gillies RJ, Huang RY, Aerts HJWL.
CA Cancer J Clin. 2019 Mar;69(2):127-157. doi: 10.3322/caac.21552. Epub 2019 Feb 5. Review. PubMed
Direct estimation of mutations in great apes reconciles phylogenetic dating.
Besenbacher S, Hvilsom C, Marques-Bonet T, Mailund T, Schierup MH.
Nat Ecol Evol. 2019 Feb;3(2):286-292. doi: 10.1038/s41559-018-0778-x. Epub 2019 Jan 21. PubMed
Shared heritability and functional enrichment across six solid cancers.
Jiang X, Finucane HK, Schumacher FR, Schmit SL, Tyrer JP, Han Y, Michailidou K, Lesseur C, Kuchenbaecker KB, Dennis J, Conti DV, Casey G, Gaudet MM, Huyghe JR, Albanes D, Aldrich MC, Andrew AS, Andrulis IL, Anton-Culver H, Antoniou AC, Antonenkova NN, Arnold SM, Aronson KJ, Arun BK, Bandera EV, Barkardottir RB, Barnes DR, Batra J, Beckmann MW, Benitez J, Benlloch S, Berchuck A, Berndt SI, Bickeböller H, Bien SA, Blomqvist C, Boccia S, Bogdanova NV, Bojesen SE, Bolla MK, Brauch H, Brenner H, Brenton JD, Brook MN, Brunet J, Brunnström H, Buchanan DD, Burwinkel B, Butzow R, Cadoni G, Caldés T, Caligo MA, Campbell I, Campbell PT, Cancel-Tassin G, Cannon-Albright L, Campa D, Caporaso N, Carvalho AL, Chan AT, Chang-Claude J, Chanock SJ, Chen C, Christiani DC, Claes KBM, Claessens F, Clements J, Collée JM, Correa MC, Couch FJ, Cox A, Cunningham JM, Cybulski C, Czene K, Daly MB, deFazio A, Devilee P, Diez O, Gago-Dominguez M, Donovan JL, Dörk T, Duell EJ, Dunning AM, Dwek M, Eccles DM, Edlund CK, Edwards DRV, Ellberg C, Evans DG, Fasching PA, Ferris RL, Liloglou T, Figueiredo JC, Fletcher O, Fortner RT, Fostira F, Franceschi S, Friedman E, Gallinger SJ, Ganz PA, Garber J, García-Sáenz JA, Gayther SA, Giles GG, Godwin AK, Goldberg MS, Goldgar DE, Goode EL, Goodman MT, Goodman G, Grankvist K, Greene MH, Gronberg H, Gronwald J, Guénel P, Håkansson N, Hall P, Hamann U, Hamdy FC, Hamilton RJ, Hampe J, Haugen A, Heitz F, Herrero R, Hillemanns P, Hoffmeister M, Høgdall E, Hong YC, Hopper JL, Houlston R, Hulick PJ, Hunter DJ, Huntsman DG, Idos G, Imyanitov EN, Ingles SA, Isaacs C, Jakubowska A, James P, Jenkins MA, Johansson M, Johansson M, John EM, Joshi AD, Kaneva R, Karlan BY, Kelemen LE, Kühl T, Khaw KT, Khusnutdinova E, Kibel AS, Kiemeney LA, Kim J, Kjaer SK, Knight JA, Kogevinas M, Kote-Jarai Z, Koutros S, Kristensen VN, Kupryjanczyk J, Lacko M, Lam S, Lambrechts D, Landi MT, Lazarus P, Le ND, Lee E, Lejbkowicz F, Lenz HJ, Leslie G, Lessel D, Lester J, Levine DA, Li L, Li CI, Lindblom A, Lindor NM, Liu G, Loupakis F, Lubiński J, Maehle L, Maier C, Mannermaa A, Marchand LL, Margolin S, May T, McGuffog L, Meindl A, Middha P, Miller A, Milne RL, MacInnis RJ, Modugno F, Montagna M, Moreno V, Moysich KB, Mucci L, Muir K, Mulligan AM, Nathanson KL, Neal DE, Ness AR, Neuhausen SL, Nevanlinna H, Newcomb PA, Newcomb LF, Nielsen FC, Nikitina-Zake L, Nordestgaard BG, Nussbaum RL, Offit K, Olah E, Olama AAA, Olopade OI, Olshan AF, Olsson H, Osorio A, Pandha H, Park JY, Pashayan N, Parsons MT, Pejovic T, Penney KL, Peters WHM, Phelan CM, Phipps AI, Plaseska-Karanfilska D, Pring M, Prokofyeva D, Radice P, Stefansson K, Ramus SJ, Raskin L, Rennert G, Rennert HS, van Rensburg EJ, Riggan MJ, Risch HA, Risch A, Roobol MJ, Rosenstein BS, Rossing MA, De Ruyck K, Saloustros E, Sandler DP, Sawyer EJ, Schabath MB, Schleutker J, Schmidt MK, Setiawan VW, Shen H, Siegel EM, Sieh W, Singer CF, Slattery ML, Sorensen KD, Southey MC, Spurdle AB, Stanford JL, Stevens VL, Stintzing S, Stone J, Sundfeldt K, Sutphen R, Swerdlow AJ, Tajara EH, Tangen CM, Tardon A, Taylor JA, Teare MD, Teixeira MR, Terry MB, Terry KL, Thibodeau SN, Thomassen M, Bjørge L, Tischkowitz M, Toland AE, Torres D, Townsend PA, Travis RC, Tung N, Tworoger SS, Ulrich CM, Usmani N, Vachon CM, Van Nieuwenhuysen E, Vega A, Aguado-Barrera ME, Wang Q, Webb PM, Weinberg CR, Weinstein S, Weissler MC, Weitzel JN, West CML, White E, Whittemore AS, Wichmann HE, Wiklund F, Winqvist R, Wolk A, Woll P, Woods M, Wu AH, Wu X, Yannoukakos D, Zheng W, Zienolddiny S, Ziogas A, Zorn KK, Lane JM, Saxena R, Thomas D, Hung RJ, Diergaarde B, McKay J, Peters U, Hsu L, García-Closas M, Eeles RA, Chenevix-Trench G, Brennan PJ, Haiman CA, Simard J, Easton DF, Gruber SB, Pharoah PDP, Price AL, Pasaniuc B, Amos CI, Kraft P, Lindström S.
Nat Commun. 2019 Jan 25;10(1):431. doi: 10.1038/s41467-018-08054-4. PubMed
Clonal haematopoiesis - a source of biological noise in cell-free DNA analyses.
Abbosh C, Swanton C, Birkbak NJ.
Ann Oncol. 2019 Jan 15. doi: 10.1093/annonc/mdy552. [Epub ahead of print] No abstract available. PubMed
Long-term follow-up of RET Y791F carriers in Denmark 1994-2017: A National Cohort Study.
Høxbroe Michaelsen S, Ornstrup MJ, Poulsen MM, Bennedbaek FN, Gaustadnes M, Rossing M, Darling P, Vestergaard P, Mathiesen JS.
J Surg Oncol. 2019 Jan 15. doi: 10.1002/jso.25371. [Epub ahead of print] PubMed
ncdDetect2: improved models of the site-specific mutation rate in cancer and driver detection with robust significance evaluation.
Juul M, Madsen T, Guo Q, Bertl J, Hobolth A, Kellis M, Pedersen JS.
Bioinformatics. 2019 Jan 15;35(2):189-199. doi: 10.1093/bioinformatics/bty511.PubMed
Changes in the cohort composition of turner syndrome and severe non-diagnosis of Klinefelter, 47,XXX and 47,XYY syndrome: a nationwide cohort study.
Berglund A, Viuff MH, Skakkebæk A, Chang S, Stochholm K, Gravholt CH.
Orphanet J Rare Dis. 2019 Jan 14;14(1):16. doi: 10.1186/s13023-018-0976-2. PubMed
Completeness of RET testing in patients with medullary thyroid carcinoma in Denmark 1997-2013: a nationwide study.
Mathiesen JS, Kroustrup JP, Vestergaard P, Stochholm K, Poulsen PL, Rasmussen ÅK, Feldt-Rasmussen U, Schytte S, Londero SC, Pedersen HB, Hahn CH, Bentzen J, Möller S, Gaustadnes M, Rossing M, Nielsen FC, Brixen K, Frederiksen AL, Godballe C; Danish Thyroid Cancer Group (DATHYRCA).
Clin Epidemiol. 2019 Jan 10;11:93-99. doi: 10.2147/CLEP.S183268. eCollection 2019. PubMed
Replication of newly proposed TNM staging system for medullary thyroid carcinoma: a nationwide study.
Mathiesen JS, Kroustrup JP, Vestergaard P, Poulsen PL, Rasmussen ÅK, Feldt-Rasmussen U, Schytte S, Londero SC, Pedersen HB, Hahn CH, Bentzen J, Möller S, Gaustadnes M, Rossing M, Nielsen FC, Brixen K, Godballe C.
Endocr Connect. 2019 Jan 1;8(1):1-7. doi: 10.1530/EC-18-0494 PubMed
2018
Discordant molecular subtype classification in the basal-squamous subtype of bladder tumors and matched lymph-node metastases.
Sjödahl G, Eriksson P, Lövgren K, Marzouka NA, Bernardo C, Nordentoft I, Dyrskjøt L, Liedberg F, Höglund M.
Mod Pathol. 2018 Dec;31(12):1869-1881. doi: 10.1038/s41379-018-0096-5. Epub 2018 Jul 2. PubMed
Exploring the transcriptome of hormone-naive multifocal prostate cancer and matched lymph node metastases.
Schmidt L, Møller M, Haldrup C, Strand SH, Vang S, Hedegaard J, Høyer S, Borre M, Ørntoft T, Sørensen KD.
Br J Cancer. 2018 Dec;119(12):1527-1537. doi: 10.1038/s41416-018-0321-5. Epub 2018 Nov 19. PubMed
Impaired aortic distensibility and elevated central blood pressure in Turner Syndrome: a cardiovascular magnetic resonance study.
Wen J, Trolle C, Viuff MH, Ringgaard S, Laugesen E, Gutmark EJ, Subramaniam DR, Backeljauw P, Gutmark-Little I, Andersen NH, Mortensen KH, Gravholt CH.
J Cardiovasc Magn Reson. 2018 Dec 13;20(1):80. doi: 10.1186/s12968-018-0497-0. PubMed
Regmex: a statistical tool for exploring motifs in ranked sequence lists from genomics experiments.
Nielsen MM, Tataru P, Madsen T, Hobolth A, Pedersen JS.
Algorithms Mol Biol. 2018 Dec 8;13:17. doi: 10.1186/s13015-018-0135-2. eCollection 2018. PubMed
Diagnostic and Prognostic MicroRNA Biomarkers for Prostate Cancer in Cell-free Urine.
Fredsøe J, Rasmussen AKI, Thomsen AR, Mouritzen P, Høyer S, Borre M, Ørntoft TF, Sørensen KD.
Eur Urol Focus. 2018 Dec;4(6):825-833. doi: 10.1016/j.euf.2017.02.018. Epub 2017 Mar 9. PubMed
Biology of nonmuscle-invasive bladder cancer: pathology, genomic implications, and immunology.
Dyrskjøt L, Ingersoll MA.
Curr Opin Urol. 2018 Nov;28(6):598-603. doi: 10.1097/MOU.0000000000000543. Review. PubMed
Exploring the transcriptome of hormone-naive multifocal prostate cancer and matched lymph node metastases.
Schmidt L, Møller M, Haldrup C, Strand SH, Vang S, Hedegaard J, Høyer S, Borre M, Ørntoft T, Sørensen KD.
Br J Cancer. 2018 Nov 19. doi: 10.1038/s41416-018-0321-5. [Epub ahead of print] PubMed
Germline variation at 8q24 and prostate cancer risk in men of European ancestry.
Matejcic M, Saunders EJ, Dadaev T, Brook MN, Wang K, Sheng X, Olama AAA, Schumacher FR, Ingles SA, Govindasami K, Benlloch S, Berndt SI, Albanes D, Koutros S, Muir K, Stevens VL, Gapstur SM, Tangen CM, Batra J, Clements J, Gronberg H, Pashayan N, Schleutker J, Wolk A, West C, Mucci L, Kraft P, Cancel-Tassin G, Sorensen KD, Maehle L, Grindedal EM, Strom SS, Neal DE, Hamdy FC, Donovan JL, Travis RC, Hamilton RJ, Rosenstein B, Lu YJ, Giles GG, Kibel AS, Vega A, Bensen JT, Kogevinas M, Penney KL, Park JY, Stanford JL, Cybulski C, Nordestgaard BG, Brenner H, Maier C, Kim J, Teixeira MR, Neuhausen SL, De Ruyck K, Razack A, Newcomb LF, Lessel D, Kaneva R, Usmani N, Claessens F, Townsend PA, Dominguez MG, Roobol MJ, Menegaux F, Khaw KT, Cannon-Albright LA, Pandha H, Thibodeau SN, Schaid DJ; PRACTICAL (Prostate Cancer Association Group to Investigate Cancer-Associated Alterations in the Genome) Consortium, Wiklund F, Chanock SJ, Easton DF, Eeles RA, Kote-Jarai Z, Conti DV, Haiman CA.
Nat Commun. 2018 Nov 5;9(1):4616. doi: 10.1038/s41467-018-06863-1. PubMed
Implantable cardioverter-defibrillator therapy and device-related complications in youngpatients with inherited cardiomyopathies or channelopathies: a 17-year cohort study.
Petersen LDD, Christiansen MK, Pedersen LN, Nielsen JC, Broendberg AK, Jensen HK.
Europace. 2018 Nov 1;20(11):1849-1855. doi: 10.1093/europace/euy081. PubMed
Triage for selection to colonoscopy?
Mertz-Petersen M, Piper TB, Kleif J, Ferm L, Christensen IJ, Nielsen HJ; Danish Collaborative Group on Early Detection of Colorectal Neoplasia.
Eur J Surg Oncol. 2018 Oct;44(10):1539-1541. doi: 10.1016/j.ejso.2018.06.013. Epub 2018 Jun 23. PubMed
Can secondary contact following range expansion be distinguished from barriers to gene flow?
Bertl J, Ringbauer H, Blum MGB.
PeerJ. 2018 Oct 1;6:e5325. doi: 10.7717/peerj.5325. eCollection 2018. PubMed
Circulating Metabolic Biomarkers of Screen-Detected Prostate Cancer in the ProtecT Study.
Adams CD, Richmond R, Ferreira DLS, Spiller W, Tan V, Zheng J, Würtz P, Donovan J, Hamdy F, Neal D, Lane JA, Smith GD, Relton C, Eeles RA, Haiman CA, Kote-Jarai Z, Schumacher FR, Olama AAA, Benlloch S, Muir K, Berndt SI, Conti DV, Wiklund F, Chanock SJ, Gapstur S, Stevens VL, Tangen CM, Batra J, Clements JA, Gronberg H, Pashayan N, Schleutker J, Albanes D, Wolk A, West CML, Mucci LA, Cancel-Tassin G, Koutros S, Sorensen KD, Maehle L, Travis RC, Hamilton RJ, Ingles SA, Rosenstein BS, Lu YJ, Giles GG, Kibel AS, Vega A, Kogevinas M, Penney KL, Park JY, Stanford JL, Cybulski C, Nordestgaard BG, Brenner H, Maier C, Kim J, John EM, Teixeira MR, Neuhausen SL, De Ruyck K, Razack A, Newcomb LF, Lessel D, Kaneva RP, Usmani N, Claessens F, Townsend PA, Dominguez MG, Roobol MJ, Menegaux F, Khaw KT, Cannon-Albright LA, Pandha H, Thibodeau SN, Martin RM; PRACTICAL consortium.
Cancer Epidemiol Biomarkers Prev. 2019 Jan;28(1):208-216. doi: 10.1158/1055-9965.EPI-18-0079. Epub 2018 Oct 23. PubMed
Picomolar sensitive and SNP-selective "Off-On" hairpin genosensor based on structure-tunable redox indicator signals.
Kékedy-Nagy L, Sørensen KD, Ferapontova EE.
Biosens Bioelectron. 2018 Oct 15;117:444-449. doi: 10.1016/j.bios.2018.06.040. Epub 2018 Jun 22. PubMed
Incidence and prevalence of multiple endocrine neoplasia 2A in Denmark 1901-2014: a nationwide study.
Mathiesen JS, Kroustrup JP, Vestergaard P, Stochholm K, Poulsen PL, Rasmussen ÅK, Feldt-Rasmussen U, Schytte S, Pedersen HB, Hahn CH, Bentzen J, Möller S, Gaustadnes M, Rossing M, Nielsen FC, Brixen K, Frederiksen AL, Godballe C.
Clin Epidemiol. 2018 Oct 12;10:1479-1487. doi: 10.2147/CLEP.S174606. eCollection 2018. PubMed
Proteomic profiling identifies outcome-predictive markers in patients with peripheral T-cell lymphoma, not otherwise specified.
Ludvigsen M, Bjerregård Pedersen M, Lystlund Lauridsen K, Svenstrup Poulsen T, Hamilton-Dutoit SJ, Besenbacher S, Bendix K, Møller MB, Nørgaard P, d'Amore F, Honoré B.
Blood Adv. 2018 Oct 9;2(19):2533-2542. doi: 10.1182/bloodadvances.2018019893. PubMed
Large-scale transcriptome-wide association study identifies new prostate cancer risk regions.
Mancuso N, Gayther S, Gusev A, Zheng W, Penney KL, Kote-Jarai Z, Eeles R, Freedman M, Haiman C, Pasaniuc B; PRACTICAL consortium.
Nat Commun. 2018 Oct 4;9(1):4079. doi: 10.1038/s41467-018-06302-1. Erratum in: Nat Commun. 2019 Jan 8;10(1):171. PubMed
TIMP3 and TIMP1 are risk genes for bicuspid aortic valve and aortopathy in Turner syndrome.
Corbitt H, Morris SA, Gravholt CH, Mortensen KH, Tippner-Hedges R, Silberbach M, Maslen CL; GenTAC Registry Investigators.
PLoS Genet. 2018 Oct 3;14(10):e1007692. doi: 10.1371/journal.pgen.1007692. eCollection 2018 Oct. PubMed
Identification of multiple risk loci and regulatory mechanisms influencing susceptibility to multiple myeloma.
Went M, Sud A, Försti A, Halvarsson BM, Weinhold N, Kimber S, van Duin M, Thorleifsson G, Holroyd A, Johnson DC, Li N, Orlando G, Law PJ, Ali M, Chen B, Mitchell JS, Gudbjartsson DF, Kuiper R, Stephens OW, Bertsch U, Broderick P, Campo C, Bandapalli OR, Einsele H, Gregory WA, Gullberg U, Hillengass J, Hoffmann P, Jackson GH, Jöckel KH, Johnsson E, Kristinsson SY, Mellqvist UH, Nahi H, Easton D, Pharoah P, Dunning A, Peto J, Canzian F, Swerdlow A, Eeles RA, Kote-Jarai Z, Muir K, Pashayan N, Nickel J, Nöthen MM, Rafnar T, Ross FM, da Silva Filho MI, Thomsen H, Turesson I, Vangsted A, Andersen NF, Waage A, Walker BA, Wihlborg AK, Broyl A, Davies FE, Thorsteinsdottir U, Langer C, Hansson M, Goldschmidt H, Kaiser M, Sonneveld P, Stefansson K, Morgan GJ, Hemminki K, Nilsson B, Houlston RS; PRACTICAL consortium.
Nat Commun. 2018 Sep 13;9(1):3707. doi: 10.1038/s41467-018-04989-w. Erratum in: Nat Commun. 2019 Jan 10;10(1):213. PubMed
DNA hypermethylation and differential gene expression associated with Klinefelter syndrome.
Skakkebæk A, Nielsen MM, Trolle C, Vang S, Hornshøj H, Hedegaard J, Wallentin M, Bojesen A, Hertz JM, Fedder J, Østergaard JR, Pedersen JS, Gravholt CH.
Sci Rep. 2018 Sep 13;8(1):13740. doi: 10.1038/s41598-018-31780-0. PubMed
Letter by Groth et al Regarding Article, "Impact of Pathogenic FBN1 (Fibrillin-1) Variant Types on the Progression of Aortic Disease in Patients With Marfan Syndrome".
Groth KA, Gravholt CH, Andersen NH.
Circ Genom Precis Med. 2018 Sep;11(9):e002319. doi: 10.1161/CIRCGEN.118.002319. No abstract available. PubMed
Training and validation of a novel 4-miRNA ratio model (MiCaP) for prediction of postoperative outcome in prostate cancer patients.
Schmidt L, Fredsøe J, Kristensen H, Strand SH, Rasmussen A, Høyer S, Borre M, Mouritzen P, Ørntoft T, Sørensen KD.
Ann Oncol. 2018 Sep 1;29(9):2003-2009. doi: 10.1093/annonc/mdy243. PubMed
FOXM1 predicts disease progression in non-muscle invasive bladder cancer.
Rinaldetti S, Wirtz R, Worst TS, Hartmann A, Breyer J, Dyrskjot L, Erben P.
J Cancer Res Clin Oncol. 2018 Sep;144(9):1701-1709. doi: 10.1007/s00432-018-2694-5. Epub 2018 Jun 29. PubMed
Contribution of allelic imbalance to colorectal cancer.
Palin K, Pitkänen E, Turunen M, Sahu B, Pihlajamaa P, Kivioja T, Kaasinen E, Välimäki N, Hänninen UA, Cajuso T, Aavikko M, Tuupanen S, Kilpivaara O, van den Berg L, Kondelin J, Tanskanen T, Katainen R, Grau M, Rauanheimo H, Plaketti RM, Taira A, Sulo P, Hartonen T, Dave K, Schmierer B, Botla S, Sokolova M, Vähärautio A, Gladysz K, Ongen H, Dermitzakis E, Bramsen JB, Ørntoft TF, Andersen CL, Ristimäki A, Lepistö A, Renkonen-Sinisalo L, Mecklin JP, Taipale J, Aaltonen LA.
Nat Commun. 2018 Sep 10;9(1):3664. doi: 10.1038/s41467-018-06132-1. PubMed
STAG2 Is a Biomarker for Prediction of Recurrence and Progression in Papillary Non-Muscle-Invasive Bladder Cancer.
Lelo A, Prip F, Harris BT, Solomon D, Berry DL, Chaldekas K, Kumar A, Simko J, Jensen JB, Bhattacharyya P, Mannion C, Kim JS, Philips G, Dyrskjøt L, Waldman T.
Clin Cancer Res. 2018 Sep 1;24(17):4145-4153. doi: 10.1158/1078-0432.CCR-17-3244. Epub 2018 Jun 28. PubMed
Dysregulation and prognostic potential of 5-methylcytosine (5mC), 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC), and 5-carboxylcytosine (5caC) levels in prostate cancer.
Storebjerg TM, Strand SH, Høyer S, Lynnerup AS, Borre M, Ørntoft TF, Sørensen KD.
Clin Epigenetics. 2018 Aug 7;10(1):105. doi: 10.1186/s13148-018-0540-x. PubMed
Causes of Mortality in the Marfan Syndrome(from a Nationwide Register Study).
Groth KA, Stochholm K, Hove H, Andersen NH, Gravholt CH.
Am J Cardiol. 2018 Oct 1;122(7):1231-1235. doi: 10.1016/j.amjcard.2018.06.034. Epub 2018 Jul 21. PubMed
Klinefelter Syndrome: Integrating Genetics, Neuropsychology, and Endocrinology.
Gravholt CH, Chang S, Wallentin M, Fedder J, Moore P, Skakkebæk A.
Endocr Rev. 2018 Aug 1;39(4):389-423. doi: 10.1210/er.2017-00212. Review. PubMed
Original article: Training and validation of a novel 4-miRNA ratio model (MiCaP) for prediction of post-operative outcome in prostate cancer patients.
Schmidt L, Fredsøe J, Kristensen H, Strand SH, Rasmussen A, Høyer S, Borre M, Mouritzen P, Ørntoft T, Dalsgaard Sørensen K.
Ann Oncol. 2018 Jul 13. doi: 10.1093/annonc/mdy243. [Epub ahead of print] PubMed
ncdDetect2: Improved models of the site-specific mutation rate in cancer and driver detection with robust significance evaluation.
Juul M, Madsen T, Guo Q, Bertl J, Hobolth A, Kellis M, Pedersen JS.
Bioinformatics. 2018 Jun 26. doi: 10.1093/bioinformatics/bty511. [Epub ahead of print] PubMed
Accurate genotyping across variant classes and lengths using variant graphs.
Sibbesen JA, Maretty L; Danish Pan-Genome Consortium, Krogh A.
Nat Genet. 2018 Jun 18. doi: 10.1038/s41588-018-0145-5. [Epub ahead of print] PubMed
Fine-mapping of prostate cancer susceptibility loci in a large meta-analysis identifies candidate causal variants.
Dadaev T, Saunders EJ, Newcombe PJ, Anokian E, Leongamornlert DA, Brook MN, Cieza-Borrella C, Mijuskovic M, Wakerell S, Olama AAA, Schumacher FR, Berndt SI, Benlloch S, Ahmed M, Goh C, Sheng X, Zhang Z, Muir K, Govindasami K, Lophatananon A, Stevens VL, Gapstur SM, Carter BD, Tangen CM, Goodman P, Thompson IM Jr, Batra J, Chambers S, Moya L, Clements J, Horvath L, Tilley W, Risbridger G, Gronberg H, Aly M, Nordström T, Pharoah P, Pashayan N, Schleutker J, Tammela TLJ, Sipeky C, Auvinen A, Albanes D, Weinstein S, Wolk A, Hakansson N, West C, Dunning AM, Burnet N, Mucci L, Giovannucci E, Andriole G, Cussenot O, Cancel-Tassin G, Koutros S, Freeman LEB, Sorensen KD, Orntoft TF, Borre M, Maehle L, Grindedal EM, Neal DE, Donovan JL, Hamdy FC, Martin RM, Travis RC, Key TJ, Hamilton RJ, Fleshner NE, Finelli A, Ingles SA, Stern MC, Rosenstein B, Kerns S, Ostrer H, Lu YJ, Zhang HW, Feng N, Mao X, Guo X, Wang G, Sun Z, Giles GG, Southey MC, MacInnis RJ, FitzGerald LM, Kibel AS, Drake BF, Vega A, Gómez-Caamaño A, Fachal L, Szulkin R, Eklund M, Kogevinas M, Llorca J, Castaño-Vinyals G, Penney KL, Stampfer M, Park JY, Sellers TA, Lin HY, Stanford JL, Cybulski C, Wokolorczyk D, Lubinski J, Ostrander EA, Geybels MS, Nordestgaard BG, Nielsen SF, Weisher M, Bisbjerg R, Røder MA, Iversen P, Brenner H, Cuk K, Holleczek B, Maier C, Luedeke M, Schnoeller T, Kim J, Logothetis CJ, John EM, Teixeira MR, Paulo P, Cardoso M, Neuhausen SL, Steele L, Ding YC, De Ruyck K, De Meerleer G, Ost P, Razack A, Lim J, Teo SH, Lin DW, Newcomb LF, Lessel D, Gamulin M, Kulis T, Kaneva R, Usmani N, Slavov C, Mitev V, Parliament M, Singhal S, Claessens F, Joniau S, Van den Broeck T, Larkin S, Townsend PA, Aukim-Hastie C, Gago-Dominguez M, Castelao JE, Martinez ME, Roobol MJ, Jenster G, van Schaik RHN, Menegaux F, Truong T, Koudou YA, Xu J, Khaw KT, Cannon-Albright L, Pandha H, Michael A, Kierzek A, Thibodeau SN, McDonnell SK, Schaid DJ, Lindstrom S, Turman C, Ma J, Hunter DJ, Riboli E, Siddiq A, Canzian F, Kolonel LN, Le Marchand L, Hoover RN, Machiela MJ, Kraft P; PRACTICAL (Prostate Cancer Association Group to Investigate Cancer-Associated Alterations in the Genome) Consortium, Freedman M, Wiklund F, Chanock S, Henderson BE, Easton DF, Haiman CA, Eeles RA, Conti DV, Kote-Jarai Z.
Nat Commun. 2018 Jun 11;9(1):2256. doi: 10.1038/s41467-018-04109-8. PubMed
Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci.
Schumacher FR, Al Olama AA, Berndt SI, Benlloch S, Ahmed M, Saunders EJ, Dadaev T, Leongamornlert D, Anokian E, Cieza-Borrella C, Goh C, Brook MN, Sheng X, Fachal L, Dennis J, Tyrer J, Muir K, Lophatananon A, Stevens VL, Gapstur SM, Carter BD, Tangen CM, Goodman PJ, Thompson IM Jr, Batra J, Chambers S, Moya L, Clements J, Horvath L, Tilley W, Risbridger GP, Gronberg H, Aly M, Nordström T, Pharoah P, Pashayan N, Schleutker J, Tammela TLJ, Sipeky C, Auvinen A, Albanes D, Weinstein S, Wolk A, Håkansson N, West CML, Dunning AM, Burnet N, Mucci LA, Giovannucci E, Andriole GL, Cussenot O, Cancel-Tassin G, Koutros S, Beane Freeman LE, Sorensen KD, Orntoft TF, Borre M, Maehle L, Grindedal EM, Neal DE, Donovan JL, Hamdy FC, Martin RM, Travis RC, Key TJ, Hamilton RJ, Fleshner NE, Finelli A, Ingles SA, Stern MC, Rosenstein BS, Kerns SL, Ostrer H, Lu YJ, Zhang HW, Feng N, Mao X, Guo X, Wang G, Sun Z, Giles GG, Southey MC, MacInnis RJ, FitzGerald LM, Kibel AS, Drake BF, Vega A, Gómez-Caamaño A, Szulkin R, Eklund M, Kogevinas M, Llorca J, Castaño-Vinyals G, Penney KL, Stampfer M, Park JY, Sellers TA, Lin HY, Stanford JL, Cybulski C, Wokolorczyk D, Lubinski J, Ostrander EA, Geybels MS, Nordestgaard BG, Nielsen SF, Weischer M, Bisbjerg R, Røder MA, Iversen P, Brenner H, Cuk K, Holleczek B, Maier C, Luedeke M, Schnoeller T, Kim J, Logothetis CJ, John EM, Teixeira MR, Paulo P, Cardoso M, Neuhausen SL, Steele L, Ding YC, De Ruyck K, De Meerleer G, Ost P, Razack A, Lim J, Teo SH, Lin DW, Newcomb LF, Lessel D, Gamulin M, Kulis T, Kaneva R, Usmani N, Singhal S, Slavov C, Mitev V, Parliament M, Claessens F, Joniau S, Van den Broeck T, Larkin S, Townsend PA, Aukim-Hastie C, Dominguez MG, Castelao JE, Martinez ME, Roobol MJ, Jenster G, van Schaik RHN, Menegaux F, Truong T, Koudou YA; Profile Study, Xu J, Khaw KT, Cannon-Albright L, Pandha H, Michael A, Thibodeau SN, McDonnell SK, Schaid DJ, Lindstrom S, Turman C, Ma J, Hunter DJ, Riboli E, Siddiq A, Canzian F, Kolonel LN, Le Marchand L, Hoover RN, Machiela MJ, Cui Z, Kraft P; Australian Prostate Cancer BioResource (APCB); IMPACT Study; Canary PASS Investigators; Breast and Prostate Cancer Cohort Consortium (BPC3); PRACTICAL (Prostate Cancer Association Group to Investigate Cancer-Associated Alterations in the Genome) Consortium; Cancer of the Prostate in Sweden (CAPS); Prostate Cancer Genome-wide Association Study of Uncommon Susceptibility Loci (PEGASUS); Genetic Associations and Mechanisms in Oncology (GAME-ON)/Elucidating Loci Involved in Prostate Cancer Susceptibility (ELLIPSE) Consortium, Amos CI, Conti DV, Easton DF, Wiklund F, Chanock SJ, Henderson BE, Kote-Jarai Z, Haiman CA, Eeles RA.
Nat Genet. 2018 Jun 11. doi: 10.1038/s41588-018-0142-8. [Epub ahead of print] PubMed
Avoidable colorectal cancer cases in Denmark - The impact of red and processed meat.
Lourenço S, Gunge VB, Andersson TM, Andersen CLE, Lund AQ, Køster B, Hansen GL.
Cancer Epidemiol. 2018 May 25;55:1-7. doi: 10.1016/j.canep.2018.04.010. [Epub ahead of print] PubMed
A site specific model and analysis of the neutral somatic mutation rate in whole-genome cancer data.
Bertl J, Guo Q, Juul M, Besenbacher S, Nielsen MM, Hornshøj H, Pedersen JS, Hobolth A.
BMC Bioinformatics. 2018 Apr 19;19(1):147. doi: 10.1186/s12859-018-2141-2. PubMed
Morbidity, Mortality, and Socioeconomics in Females With 46,XY Disorders of Sex Development: A Nationwide Study.
Berglund A, Johannsen TH, Stochholm K, Viuff MH, Fedder J, Main KM, Gravholt CH.
J Clin Endocrinol Metab. 2018 Apr 1;103(4):1418-1428. doi: 10.1210/jc.2017-01888. PubMed
Biomarker potential of ST6GALNAC3 and ZNF660 promoter hypermethylation in prostate cancer tissue and liquid biopsies.
Haldrup C, Pedersen AL, Øgaard N, Strand SH, Høyer S, Borre M, Ørntoft TF, Sørensen KD.
Mol Oncol. 2018 Apr;12(4):545-560. doi: 10.1002/1878-0261.12183. Epub 2018 Mar 13. PubMed
Circulating tumour DNA analyses reveal novel resistance mechanisms to CDK inhibition in metastatic breast cancer.
Abbosh C, Swanton C, Birkbak NJ.
Ann Oncol. 2018 Mar 1;29(3):535-537. doi: 10.1093/annonc/mdy017. No abstract available. PubMed
Perceptions about screening for prostate cancer using genetic lifetime risk assessment: a qualitative study.
Kirkegaard P, Edwards A, Nielsen TLO, Ørntoft TF, Sørensen KD, Borre M, Bro F.
BMC Fam Pract . 2018 Feb 17;19(1):32. doi: 10.1186/s12875-018-0717-6. PubMed
Molecular-Subtype-Specific Biomarkers Improve Prediction of Prognosis in Colorectal Cancer.
Bramsen JB, Rasmussen MH, Ongen H, Mattesen TB, Ørntoft MW, Árnadóttir SS, Sandoval J, Laguna T, Vang S, Øster B, Lamy P, Madsen MR, Laurberg S, Esteller M, Dermitzakis ET, Ørntoft TF, Andersen CL.
Cell Rep. 2017 May 9;19(6):1268-1280. doi: 10.1016/j.celrep.2017.04.045. PubMed
Implantable cardioverter-defibrillator therapy and device-related complications in youngpatients with inherited cardiomyopathies or channelopathies: a 17-year cohort study.
Petersen LDD, Christiansen MK, Pedersen LN, Nielsen JC, Broendberg AK, Jensen HK.
Europace. 2018 Apr 25. doi: 10.1093/europace/euy081. [Epub ahead of print] PubMed
Targeted next generation sequencing in a young population with suspected inherited malignant cardiac arrhythmias.
Broendberg AK, Christiansen MK, Nielsen JC, Pedersen LN, Jensen HK.
Eur J Hum Genet. 2018 Mar;26(3):303-313. doi: 10.1038/s41431-017-0060-8. Epub 2018 Jan 17. PubMed
Quality of life in men with Klinefelter syndrome: the impact of genotype, health, socioeconomics, and sexual function.
Skakkebæk A, Moore PJ, Chang S, Fedder J, Gravholt CH.
Genet Med. 2018 Feb;20(2):214-222. doi: 10.1038/gim.2017.110. Epub 2017 Jul 20. PubMed
Molecular markers increase precision of the European Association of Urology non-muscle invasive bladder cancer progression risk groups.
Van Kessel KE, van der Keur KA, Dyrskjøt L, Algaba F, Welvaart NY, Beukers W, Segersten U, Keck B, Maurer T, Simic T, Horstmann M, Grimm MO, Hermann GG, Mogensen K, Hartmann A, Harving N, Petersen AC, Jensen JB, Junker K, Boormans JL, Real FX, Malats N, Malmström PU, Ørntoft TF, Zwarthoff EC.
Clin Cancer Res. 2018 Apr 1;24(7):1586-1593. doi: 10.1158/1078-0432.CCR-17-2719. Epub 2018 Jan 24. PubMed
Pan-cancer screen for mutations in non-coding elements with conservation and cancer specificity reveals correlations with expression and survival.
Hornshøj H, Nielsen MM, Sinnott-Armstrong NA, Świtnicki MP, Juul M, Madsen T, Sallari R, Kellis M, Ørntoft T, Hobolth A, Pedersen JS.
NPJ Genom Med. 2018 Jan 11;3:1. doi: 10.1038/s41525-017-0040-5. eCollection 2018. PubMed
Characterization of genetic intratumor heterogeneity in colorectal cancer and matching patient-derived spheroid cultures.
Árnadóttir SS, Jeppesen M, Lamy P, Bramsen JB, Nordentoft I, Knudsen M, Vang S, Madsen MR, Thastrup O, Thastrup J, L Andersen C.
Mol Oncol. 2018 Jan;12(1):132-147. doi: 10.1002/1878-0261.12156. Epub 2017 Nov 27. PubMed
Optimized targeted sequencing of cell-free plasma DNA from bladder cancer patients.
Christensen E, Nordentoft I, Vang S, Birkenkamp-Demtröder K, Jensen JB, Agerbæk M, Pedersen JS, Dyrskjøt L.
Sci Rep. 2018 Jan 30;8(1):1917. doi: 10.1038/s41598-018-20282-8. PubMed
2017
Circular RNAs are abundantly expressed and upregulated during human epidermal stem cell differentiation.
Kristensen LS, Okholm TLH, Venø MT, Kjems J.
RNA Biol. 2017 Dec 28:1-12. doi: 10.1080/15476286.2017.1409931. [Epub ahead of print] PubMed
Founder effect of the RET C611Y mutation in multiple endocrine neoplasia 2A in Denmark: A nationwide study.
Mathiesen, JS, Kroustrup, JP, Vestergaard, P, Stochholm, K, Poulsen, PL, Rasmussen, ÅK, Feldt-Rasmussen, U, Gaustadnes, M, Ørntoft, TF, Rossing, M, Nielsen, FC, Albrechtsen, A, Brixen, K, Godballe, C, Frederiksen, AL.
Thyroid. 2017 Dec;27(12):1505-1510. doi: 10.1089/thy.2017.0404. Epub 2017 Nov 3. PubMed
Loss-of-activity-mutation in the cardiac chloride-bicarbonate exchanger AE3 causes short QT syndrome.
Thorsen, Kasper; Dam, Vibeke S.; Kjaer-Sorensen, Kasper; Pedersen, Lisbeth N.; Skeberdis, V. Arvydas; Jurevičius, Jonas; Treinys, Rimantas; Petersen, Ida M.B.S.; Nielsen, Morten S.; Oxvig, Claus; Morth, J. Preben; Matchkov, Vladimir V.; Aalkjær, Christian; Bundgaard, Henning; Jensen, Henrik K.
Nature Communications, Vol. 8, No. 1, 1696, 01.12.2017. PubMed
Prognostic miRNA classifier in early-stage mycosis fungoides: development and validation in a Danish nationwide study.
Lindahl LM, Besenbacher S, Rittig AH, Celis P, Willerslev-Olsen A, Gjerdrum LMR, Krejsgaard T, Johansen C, Litman T, Woetmann A, Odum N, Iversen L.
Blood. 2017 Dec 5. pii: blood-2017-06-788950. doi: 10.1182/blood-2017-06-788950. [Epub ahead of print] PubMed
A Rare Case of Embryonal Carcinoma in a Patient with Turner Syndrome without Y Chromosomal Material but Mutations in KIT, AKT1, and ZNF358 Demonstrated Using Exome Sequencing.
Gravholt CH, Dollerup OL, Duval L, Mejlgaard E, Stribolt K, Vang S, Laursen BE, Knudsen M, Thorsen K, Hersmus R, Looijenga LHJ, Stochholm K.
Sex Dev. 2017 Dec 2. doi: 10.1159/000484398. [Epub ahead of print] PubMed
Circular RNA expression is abundant and correlated to aggressiveness in early-stage bladder cancer.
Okholm TLH, Nielsen MM, Hamilton MP, Christensen LL, Vang S, Hedegaard J, Hansen TB, Kjems J, Dyrskjøt L, Pedersen JS.
NPJ Genom Med. 2017 Nov 28;2:36. doi: 10.1038/s41525-017-0038-z. eCollection 2017. PubMed
Approximate maximum likelihood estimation for population genetic inference.
Bertl J, Ewing G, Kosiol C, Futschik A.
Stat Appl Genet Mol Biol. 2017 Nov 27;16(5-6):387-405. doi: 10.1515/sagmb-2017-0016. PubMed
Pancreas specific expression of oncogenes in a porcine model.
Berthelsen MF, Callesen MM, Østergaard TS1,2, Liu Y, Li R, Callesen H, Dagnæs-Hansen F, Hamilton-Dutoit S, Jakobsen JE, Thomsen MK.
Transgenic Res. 2017 Oct;26(5):603-612. doi: 10.1007/s11248-017-0031-4. Epub 2017 Jun 29. PubMed
Enrichment of Genetic Variants in the Glucocorticoid Receptor Signalling Pathway in Autoimmune Hepatitis with Failure of Standard Treatment.
Eriksen PL, Kreutzfeldt M, Grønbaek H, Thorsen K, Vang S, Jessen N, Vilstrup H.
Basic Clin Pharmacol Toxicol. 2017 Sep;121(3):189-194. doi: 10.1111/bcpt.12788. Epub 2017 May 18. PubMed
Clinical practice guidelines for the care of girls and women with Turner syndrome: proceedings from the 2016 Cincinnati International Turner Syndrome Meeting.
Gravholt CH, Andersen NH, Conway GS, Dekkers OM, Geffner ME, Klein KO, Lin AE, Mauras N, Quigley CA, Rubin K, Sandberg DE, Sas TCJ, Silberbach M, Söderström-Anttila V, Stochholm K, van Alfen-van derVelden JA, Woelfle J, Backeljauw PF; International Turner Syndrome Consensus Group.
Eur J Endocrinol. 2017 Sep;177(3):G1-G70. doi: 10.1530/EJE-17-0430. PubMed
Assembly and analysis of 100 full MHC haplotypes from the Danish population.
Jensen JM, Villesen P, Friborg RM; Danish Pan-Genome Consortium, Mailund T, Besenbacher S, Schierup MH.
Genome Res. 2017 Sep;27(9):1597-1607. doi: 10.1101/gr.218891.116. Epub 2017 Aug 3. PubMed
Monitoring Treatment Response and Metastatic Relapse in Advanced Bladder Cancer by Liquid Biopsy Analysis.
Birkenkamp-Demtröder K, Christensen E, Nordentoft I, Knudsen M, Taber A, Høyer S, Lamy P, Agerbæk M, Jensen JB, Dyrskjøt L.
Eur Urol. 2017 Sep 25. pii: S0302-2838(17)30775-3. doi: 10.1016/j.eururo.2017.09.011. [Epub ahead of print] PubMed
Data Descriptor: Whole genome characterization of sequence diversity of 15,220 Icelanders.
Jónsson, H, Sulem, P, Kehr, B, Kristmundsdottir, S, Zink, F, Hjartarson, E, Hardarson, MT, Hjorleifsson, KE, Eggertsson, HP, Gudjonsson, SA, Ward, LD, Arnadottir, GA, Helgason, EA, Helgason, H, Gylfason, A, Jonasdottir, A, Jonasdottir, A, Rafnar, T, Besenbacher, S, Frigge, ML, Stacey, SN, Magnusson, OT, Thorsteinsdottir, U, Thorsteinsdottir, U, Masson, G, Kong, A, Kong, A, Halldorsson, BV, Halldorsson, BV, Helgason, A, Helgason, A, Gudbjartsson, DF, Gudbjartsson, DF, Stefansson, K & Stefansson, K.
Scientific Data, vol 4, 170115. DOI: 10.1038/sdata.2017.115
Whole genome characterization of sequence diversity of 15,220 Icelanders.
Jónsson H, Sulem P, Kehr B, Kristmundsdottir S, Zink F, Hjartarson E, Hardarson MT, Hjorleifsson KE, Eggertsson HP, Gudjonsson SA, Ward LD, Arnadottir GA, Helgason EA, Helgason H, Gylfason A, Jonasdottir A, Jonasdottir A, Rafnar T, Besenbacher S, Frigge ML, Stacey SN, Magnusson OT, Thorsteinsdottir U, Masson G, Kong A, Halldorsson BV, Helgason A, Gudbjartsson DF, Stefansson K.
Sci Data. 2017 Sep 21;4:170115. doi: 10.1038/sdata.2017.115. PubMed
Comprehensive Evaluation of TFF3 Promoter Hypomethylation and Molecular Biomarker Potential for Prostate Cancer Diagnosis and Prognosis.
Nørgaard M, Haldrup C, Storebjerg TM, Vestergaard EM, Wild PJ, Høyer S, Borre M, Ørntoft TF, Sørensen KD
Int J Mol Sci. 2017 Sep 20;18(9). pii: E2017. doi: 10.3390/ijms18092017. PubMed
Comprehensive multiregional analysis of molecular heterogeneity in bladder cancer.
Thomsen MBH, Nordentoft I, Lamy P, Vang S, Reinert L, Mapendano CK, Høyer S, Ørntoft TF, Jensen JB, Dyrskjøt L.
Sci Rep. 2017 Sep 15;7(1):11702. doi: 10.1038/s41598-017-11291-0. PubMed
A genetically inducible porcine model of intestinal cancer.
Callesen MM, Árnadóttir SS, Lyskjaer I, Ørntoft MW, Høyer S, Dagnaes-Hansen F, Liu Y, Li R, Callesen H, Rasmussen MH, Berthelsen MF, Thomsen MK, Schweiger PJ, Jensen KB, Laurberg S, Ørntoft TF, Elverløv-Jakobsen JE, Lindbjerg Andersen C.
Mol Oncol. 2017 Sep 7. doi: 10.1002/1878-0261.12136. [Epub ahead of print] PubMed
Comparative analysis of 12 different kits for bisulfite conversion of circulating cell-free DNA.
Worm Ørntoft MB, Jensen SØ, Hansen TB, Bramsen JB, Andersen CL.
Epigenetics. 2017 Aug;12(8):626-636. doi: 10.1080/15592294.2017.1334024. Epub 2017 May 30. PubMed
Direct detection of early-stage cancers using circulating tumor DNA.
Phallen J, Sausen M, Adleff V, Leal A, Hruban C, White J, Anagnostou V, Fiksel J, Cristiano S, Papp E, Speir S, Reinert T, Orntoft MW, Woodward BD, Murphy D, Parpart-Li S, Riley D, Nesselbush M, Sengamalay N, Georgiadis A, Li QK, Madsen MR, Mortensen FV, Huiskens J, Punt C, van Grieken N, Fijneman R, Meijer G, Husain H, Scharpf RB, Diaz LA Jr, Jones S, Angiuoli S, Ørntoft T, Nielsen HJ, Andersen CL, Velculescu VE.
Sci Transl Med. 2017 Aug 16;9(403). pii: eaan2415. doi: 10.1126/scitranslmed.aan2415. PubMed
Sequencing and de novo assembly of 150 genomes from Denmark as a population reference.
Maretty L, Jensen JM, Petersen B, Sibbesen JA, Liu S, Villesen P, Skov L, Belling K, Theil Have C, Izarzugaza JMG, Grosjean M, Bork-Jensen J, Grove J, Als TD, Huang S, Chang Y, Xu R, Ye W, Rao J, Guo X, Sun J, Cao H, Ye C, van Beusekom J, Espeseth T, Flindt E, Friborg RM, Halager AE, Le Hellard S, Hultman CM, Lescai F, Li S, Lund O, Løngren P, Mailund T, Matey-Hernandez ML, Mors O, Pedersen CNS, Sicheritz-Pontén T, Sullivan P, Syed A, Westergaard D, Yadav R, Li N, Xu X, Hansen T, Krogh A, Bolund L, Sørensen TIA, Pedersen O, Gupta R, Rasmussen S, Besenbacher S, Børglum AD, Wang J, Eiberg H, Kristiansen K, Brunak S, Schierup MH.
Nature. 2017 Aug 3;548(7665):87-91. doi: 10.1038/nature23264. Epub 2017 Jul 26. PubMed
Prediction of Primary Tumors in Cancers of Unknown Primary.
Søndergaard D, Nielsen S, Pedersen CNS, Besenbacher S.
J Integr Bioinform. 2017 Jul 7;14(2). pii: /j/jib.2017.14.issue-2/jib-2017-0013/jib-2017-0013.xml. doi: 10.1515/jib-2017-0013. PubMed
Clinical implications of monitoring circulating tumor DNA in patients with colorectal cancer.Schøler LV, Reinert T, Ørntoft MW, Kassentoft CG, Árnadóttir SS, Vang S, Nordentoft I, Knudsen M, Lamy P, Andreasen D, Mortensen FV, Knudsen AR, Stribolt K, Sivesgaard K, Mouritzen P, Nielsen HJ, Laurberg S, Ørntoft TF, Andersen CL.
Clin Cancer Res. 2017 Jun 9. pii: clincanres.0510.2017. doi: 10.1158/1078-0432.CCR-17-0510. [Epub ahead of print] PubMed
An Optimized Shotgun Strategy for the Rapid Generation of Comprehensive Human Proteomes.
Bekker-Jensen DB, Kelstrup CD, Batth TS, Larsen SC, Haldrup C, Bramsen JB, Sørensen KD, Høyer S, Ørntoft TF, Andersen CL, Nielsen ML, Olsen JV.
Cell Syst. 2017 Jun 28;4(6):587-599.e4. doi: 10.1016/j.cels.2017.05.009. Epub 2017 Jun 7. PubMed
Prognostic Impact of a 12-gene Progression Score in Non-muscle-invasive Bladder Cancer: A Prospective Multicentre Validation Study.
Dyrskjøt L, Reinert T, Algaba F, Christensen E, Nieboer D, Hermann GG, Mogensen K, Beukers W, Marquez M, Segersten U, Høyer S, Ulhøi BP, Hartmann A, Stöhr R, Wach S, Nawroth R, Schwamborn K, Tulic C, Simic T, Junker K, Harving N, Petersen AC, Jensen JB, Keck B, Grimm MO, Horstmann M, Maurer T, Steyerberg EW, Zwarthoff EC, Real FX, Malats N, Malmström PU, Ørntoft TF.
Eur Urol. 2017 Jun 2. pii: S0302-2838(17)30475-X. doi: 10.1016/j.eururo.2017.05.040. [Epub ahead of print] PubMed
Molecular-Subtype-Specific Biomarkers Improve Prediction of Prognosis in Colorectal Cancer.
Bramsen JB, Rasmussen MH, Ongen H, Mattesen TB, Ørntoft MW, Árnadóttir SS, Sandoval J, Laguna T, Vang S, Øster B, Lamy P, Madsen MR, Laurberg S, Esteller M, Dermitzakis ET, Ørntoft TF, Andersen CL.
Cell Rep. 2017 May 9;19(6):1268-1280. doi: 10.1016/j.celrep.2017.04.045. PubMed
Incidence and prevalence of multiple endocrine neoplasia 2B in Denmark: a nationwide study.
Mathiesen JS, Kroustrup JP, Vestergaard P, Madsen M, Stochholm K, Poulsen PL, Krogh Rasmussen Å, Feldt-Rasmussen U, Schytte S, Pedersen HB, Hahn CH, Bentzen J, Gaustadnes M, Ørntoft TF, Hansen TVO, Nielsen FC, Brixen K, Frederiksen AL, Godballe C.
Endocr Relat Cancer. 2017 Apr 24. pii: ERC-17-0122. doi: 10.1530/ERC-17-0122. [Epub ahead of print] PubMed
Non-coding cancer driver candidates identified with a sample- and position-specific model of the somatic mutation rate.
Juul M, Bertl J, Guo Q, Nielsen MM, Świtnicki M, Hornshøj H, Madsen T, Hobolth A, Pedersen JS.
Elife. 2017 Mar 31;6. pii: e21778. doi: 10.7554/eLife.21778. PubMed
Profiling of long non-coding RNAs identifies LINC00958 and LINC01296 as candidate oncogenes in bladder cancer.
Seitz AK, Christensen LL, Christensen E, Faarkrog K, Ostenfeld MS, Hedegaard J, Nordentoft I, Nielsen MM, Palmfeldt J, Thomson M, Jensen MT, Nawroth R, Maurer T, Ørntoft TF, Jensen JB, Damgaard CK, Dyrskjøt L.
Sci Rep. 2017 Mar 24;7(1):395. doi: 10.1038/s41598-017-00327-0. PubMed
epiG: statistical inference and profiling of DNA methylation from whole-genome bisulfite sequencing data.
Vincent M, Mundbjerg K, Skou Pedersen J, Liang G, Jones PA, Ørntoft TF, Dalsgaard Sørensen K, Wiuf C.
Genome Biol. 2017 Feb 21;18(1):38. doi: 10.1186/s13059-017-1168-4. PubMed
The non-coding variant rs1800734 enhances DCLK3 expression through long-range interaction and promotes colorectal cancer progression.
Liu NQ, Ter Huurne M, Nguyen LN, Peng T, Wang SY, Studd JB, Joshi O, Ongen H, Bramsen JB, Yan J, Andersen CL, Taipale J, Dermitzakis ET, Houlston RS, Hubner NC, Stunnenberg HG.
Nat Commun. 2017 Feb 14;8:14418. doi: 10.1038/ncomms14418. PubMed
Nationwide experience of catecholaminergic polymorphic ventricular tachycardia caused by RyR2 mutations.
Broendberg AK, Nielsen JC, Bjerre J, Pedersen LN, Kristensen J, Henriksen FL, Bundgaard H, Jensen HK.
Heart. 2017 Jun;103(12):901-909. doi: 10.1136/heartjnl-2016-310509. Epub 2017 Feb 25. PubMed
Heterogeneous patterns of DNA methylation-based field effects in histologically normal prostate tissue from cancer patients.
Møller M, Strand SH, Mundbjerg K, Liang G, Gill I, Haldrup C, Borre M, Høyer S, Ørntoft TF, Sørensen KD.
Sci Rep. 2017 Jan 13;7:40636. doi: 10.1038/srep40636. PubMed
Assessment of Attention Deficits in Adolescent Offspring Exposed to Maternal Type 1 Diabetes.
Bytoft B, Knorr S, Vlachova Z, Jensen RB, Mathiesen ER, Beck-Nielsen H, Gravholt CH, Jensen DM, Clausen TD, Mortensen EL, Damm P.
PLoS One. 2017 Jan 10;12(1):e0169308. doi: 10.1371/journal.pone.0169308. eCollection 2017. PubMed
Identifying aggressive prostate cancer foci using a DNA methylation classifier.
Mundbjerg K, Chopra S, Alemozaffar M, Duymich C, Lakshminarasimhan R, Nichols PW, Aron M, Siegmund KD, Ukimura O, Aron M, Stern M, Gill P, Carpten JD, Ørntoft TF, Sørensen KD, Weisenberger DJ, Jones PA, Duddalwar V, Gill I, Liang G.
Genome Biol. 2017 Jan 12;18(1):3. doi: 10.1186/s13059-016-1129-3. PubMed
Liquid Biopsy Analysis of FGFR3 and PIK3CA Hotspot Mutations for Disease Surveillance in Bladder Cancer.
Christensen E, Birkenkamp-Demtröder K, Nordentoft I, Høyer S, van der Keur K, van Kessel K, Zwarthoff E, Agerbæk M, Ørntoft TF, Jensen JB, Dyrskjøt L.
Eur Urol. 2017 Jan 6. pii: S0302-2838(16)30920-4. doi: 10.1016/j.eururo.2016.12.016. [Epub ahead of print] PubMed
2016
FGFR3, TERT and OTX1 as urinary biomarker combination for surveillance of bladder cancer patients in a large prospective multicenter study.
Beukers W, van der Keur KA, Kandimalla R, Vergouwe Y, Steyerberg EW, Boormans JL, Jensen JB, Lorente JA, Real FX, Segersten U, Orntoft TF, Malats N, Malmström PU, Dyrskjot L, Zwarthoff EC.
J Urol. 2016 Dec 31. pii: S0022-5347(16)32099-7. doi: 10.1016/j.juro.2016.12.096. [Epub ahead of print] PubMed
RHCG and TCAF1 promoter hypermethylation predicts biochemical recurrence in prostate cancer patients treated by radical prostatectomy.
Strand SH, Switnicki M, Moller M, Haldrup C, Storebjerg TM, Hedegaard J, Nordentoft I, Hoyer S, Borre M, Pedersen JS, Wild PJ, Park JY, Orntoft TF, Sorensen KD.
Oncotarget. 2016 Dec 30. doi: 10.18632/oncotarget.14391. [Epub ahead of print] PubMed
SNHG5 promotes colorectal cancer cell survival by counteracting STAU1-mediated mRNA destabilization.
Damas ND, Marcatti M, Côme C, Christensen LL, Nielsen MM, Baumgartner R, Gylling HM, Maglieri G, Rundsten CF, Seemann SE, Rapin N, Thézenas S, Vang S, Ørntoft T, Andersen CL, Pedersen JS, Lund AH.
Nat Commun. 2016 Dec 22;7:13875. doi: 10.1038/ncomms13875. PubMed
Evaluating the quality of Marfan genotype-phenotype correlations in existing FBN1 databases.
Groth KA, Von Kodolitsch Y, Kutsche K, Gaustadnes M, Thorsen K, Andersen NH, Gravholt CH.
Genet Med. 2017 Jul;19(7):772-777. doi: 10.1038/gim.2016.181. Epub 2016 Dec 1. PubMed
Multi-nucleotide de novo Mutations in Humans.
Besenbacher S, Sulem P, Helgason A, Helgason H, Kristjansson H, Jonasdottir A, Jonasdottir A, Magnusson OT, Thorsteinsdottir U, Masson G, Kong A, Gudbjartsson DF, Stefansson K.
PLoS Genet. 2016 Nov 15;12(11):e1006315. doi: 10.1371/journal.pgen.1006315. eCollection 2016 Nov. PubMed
Distribution of RET mutations in multiple endocrine neoplasia 2 in Denmark 1994-2014: a nationwide study.
Mathiesen JS, Kroustrup JP, Vestergaard P, Stochholm K, Poulsen PL, Rasmussen ÅK, Feldt-Rasmussen U, Gaustadnes M, Ørntoft TF, Hansen TV, Nielsen FC, Brixen K, Godballe C, Frederiksen AL.
Thyroid. 2016 Nov 3. [Epub ahead of print] PubMed
Corrigendum: A DERL3-associated defect in the degradation of SLC2A1 mediates the Warburg effect.
Lopez-Serra P, Marcilla M, Villanueva A, Ramos-Fernandez A, Palau A, Leal L, Wahi JE, Setien-Baranda F, Szczesna K, Moutinho C, Martinez-Cardus A, Heyn H, Sandoval J, Puertas S, Vidal A, Sanjuan X, Martinez-Balibrea E, Viñals F, Perales JC, Bramsem JB, Ørntoft TF, Andersen CL, Tabernero J, McDermott U, Boxer MB, Vander Heiden MG, Albar JP, Esteller M.
Nat Commun. 2016 Nov 2;7:13467. doi: 10.1038/ncomms13467. No abstract available. PubMed
Validation of a DNA methylation-mutation urine assay to select patients with hematuria for cystoscopy.
van Kessel KE, Beukers W, Lurkin I, Ziel-van der Made A, van der Keur KA, Boormans JL, Dyrskjøt L, Márquez M, Ørntoft TF, Real FX, Segersten U, Malats N, Malmström PU, Van Criekinge W, Zwarthoff EC.
J Urol. 2016 Oct 13. pii: S0022-5347(16)31519-1. doi: 10.1016/j.juro.2016.09.118. PubMed
HNF1B variants associate with promoter methylation and regulate gene networks activated in prostate and ovarian cancer.
Ross-Adams H, Ball S, Lawrenson K, Halim S, Russell R, Wells C, Strand SH, Ørntoft TF, Larson M, Armasu S, Massie CE, Asim M, Mortensen MM, Borre M, Woodfine K, Warren AY, Lamb AD, Kay J, Whitaker H, Ramos-Montoya A, Murrell A, Sørensen KD, Fridley BL, Goode EL, Gayther SA, Masters J, Neal DE, Mills IG.
Oncotarget. 2016 Oct 9. doi: 10.18632/oncotarget.12543. PubMed
Widespread DNA hypomethylation and differential gene expression in Turner syndrome.
Trolle C, Nielsen MM, Skakkebæk A, Lamy P, Vang S, Hedegaard J, Nordentoft I, Ørntoft TF, Pedersen JS, Gravholt CH.
Sci Rep. 2016 Sep 30;6:34220. doi: 10.1038/srep34220. PubMed
The Potential of MicroRNAs as Prostate Cancer Biomarkers.
Fabris L1, Ceder Y2, Chinnaiyan AM3, Jenster GW4, Sorensen KD5, Tomlins S3, Visakorpi T6, Calin GA7.
Eur Urol. 2016 Aug;70(2):312-22. doi: 10.1016/j.eururo.2015.12.054. Epub 2016 Jan 22. PubMed
miRNA profiling of circulating EpCAM(+) extracellular vesicles: promising biomarkers of colorectal cancer.
Ostenfeld MS, Jensen SG, Jeppesen DK, Christensen LL, Thorsen SB, Stenvang J, Hvam ML, Thomsen A, Mouritzen P, Rasmussen MH, Nielsen HJ, Ørntoft TF, Andersen CL.
J Extracell Vesicles. 2016 Aug 29;5:31488. doi: 10.3402/jev.v5.31488. eCollection 2016. PubMed
Recombinase-Mediated Cassette Exchange (RMCE)-in Reporter Cell Lines as an Alternative to the Flp-in System.
Callesen MM, Berthelsen MF, Lund S, Füchtbauer AC, Füchtbauer EM, Jakobsen JE.
PLoS One. 2016 Aug 19;11(8):e0161471. doi: 10.1371/journal.pone.0161471. eCollection 2016. PubMed
Spatial and temporal clonal evolution during development of metastatic urothelial carcinoma.
Thomsen MB, Nordentoft I, Lamy P, Høyer S, Vang S, Hedegaard J, Borre M, Jensen JB, Ørntoft TF, Dyrskjøt L.
Mol Oncol. 2016 Nov;10(9):1450-1460. doi: 10.1016/j.molonc.2016.08.003. Epub 2016 Aug 17. PubMed
miR-625-3p regulates oxaliplatin resistance by targeting MAP2K6-p38 signalling in human colorectal adenocarcinoma cells
Rasmussen MH,Lyskjær I, Jersie-Christensen RR,Tarpgaard LS,Primdal-Bengtson B, Nielsen MM, Pedersen JS, Hansen TP, Hansen F, Olsen JV, Pfeiffer P, Ørntoft TF & Andersen CL
Nature Communications 7, 2016, Aug 16;7: 12436 doi:10.1038/ncomms12436 PubMed
Paired exome analysis reveals clonal evolution and potential therapeutic targets in urothelial carcinoma.
Lamy P, Nordentoft I, Birkenkamp-Demtröder K, Borg Houlberg Thomsen M, Villesen P, Vang S, Hedegaard J, Borre M, Bjerggaard Jensen J, Høyer S, Pedersen JS, Ørntoft TF, Dyrskjøt L.
Cancer Res. 2016 Oct 1;76(19):5894-5906. Epub 2016 Aug 3. PubMed
Ectodermal dysplasia with immunodeficiency caused by a branch-point mutation in IKBKG/NEMO.
Jørgensen SE, Bøttger P, Kofod-Olsen E, Holm M, Mørk N, Ørntoft TF, Sørensen UB, Bernth-Jensen JM, Herlin T, Veirum J, Larsen CS, Østergaard L, Hartmann R, Christiansen M, Mogensen TH.
J Allergy Clin Immunol. 2016 Jun 29. pii: S0091-6749(16)30536-X. doi: 10.1016/j.jaci.2016.05.030. [Epub ahead of print] No abstract available. PubMed
SNHG16 is regulated by the Wnt pathway in colorectal cancer and affects genes involved in lipid metabolism.
Christensen LL, True K, Hamilton MP, Nielsen MM, Damas ND, Damgaard CK, Ongen H, Dermitzakis E, Bramsen JB, Pedersen JS, Lund AH, Vang S, Stribolt K, Madsen MR, Laurberg S, McGuire SE, Ørntoft TF, Andersen CL.
Mol Oncol. 2016 Oct;10(8):1266-82. doi: 10.1016/j.molonc.2016.06.003. Epub 2016 Jun 26. PubMed
Comprehensive Transcriptional Analysis of Early-Stage Urothelial Carcinoma.
Hedegaard J, Lamy P, Nordentoft I, Algaba F, Høyer S, Ulhøi BP, Vang S, Reinert T, Hermann GG, Mogensen K, Thomsen MB, Nielsen MM, Marquez M, Segersten U, Aine M, Höglund M, Birkenkamp-Demtröder K, Fristrup N, Borre M, Hartmann A, Stöhr R, Wach S, Keck B, Seitz AK, Nawroth R, Maurer T, Tulic C, Simic T, Junker K, Horstmann M, Harving N, Petersen AC, Calle ML, Steyerberg EW, Beukers W, van Kessel KE, Jensen JB, Pedersen JS, Malmström PU, Malats N, Real FX, Zwarthoff EC, Ørntoft TF, Dyrskjøt L.
Cancer Cell. 2016 Jun 16. pii: S1535-6108(16)30209-4. doi: 10.1016/j.ccell.2016.05.004. [Epub ahead of print] PubMed
Novel diagnostic and prognostic classifiers for prostate cancer identified by genome-wide microRNA profiling.
Kristensen H, Thomsen AR, Haldrup C, Dyrskjøt L, Høyer S, Borre M, Mouritzen P, Ørntoft TF, Sørensen KD.
Oncotarget. 2016 Apr 23. doi: 10.18632/oncotarget.8953. [Epub ahead of print] PubMed
The RET/PTC-RAS-BRAF linear signaling cascade mediates the motile and mitogenic phenotype of thyroid cancer cells.
Melillo RM, Castellone MD, Guarino V, De Falco V, Cirafici AM, Salvatore G, Caiazzo F, Basolo F, Giannini R, Kruhoffer M, Orntoft T, Fusco A, Santoro M.
J Clin Invest. 2016 Apr 1;126(4):1603. doi: 10.1172/JCI87345. Epub 2016 Apr 1. No abstract available. PubMed
High miR-34a expression improves response to doxorubicin in diffuse large B-cell lymphoma.
Marques SC, Ranjbar B, Laursen MB, Falgreen S, Bilgrau AE, Bødker JS, Jørgensen LK, Primo MN, Schmitz A, Ettrup MS, Johnsen HE, Bøgsted M, Mikkelsen JG, Dybkær K.
Exp Hematol. 2016 Apr;44(4):238-246.e2. doi: 10.1016/j.exphem.2015.12.007. Epub 2016 Feb 17. PubMed
Placebo-controlled, randomised clinical trial: high-dose resveratrol treatment for non-alcoholic fatty liver disease.
Heebøll S, Kreuzfeldt M, Hamilton-Dutoit S, Kjær Poulsen M, Stødkilde-Jørgensen H, Møller HJ, Jessen N, Thorsen K, Kristina Hellberg Y, Bønløkke Pedersen S, Grønbæk H.
Scand J Gastroenterol. 2016;51(4):456-64. doi: 10.3109/00365521.2015.1107620. PubMed
Alternative pre-mRNA splicing leads to potential biomarkers in diffuse large B-cell lymphoma - a systematic review
Poulsen, M. Ø., Jørgensen, L. K., Sørensen, S., et al.
Danish medical journal, vol. 63, nr. 3.2016.
Communication skills training in Denmark has come a long way.
Kjær LB, Møller JE, O’Connor M, Christiansen M, Ørntoft MW, Mørcke AM.
Ugeskr Læger 2016;178:V09150740
Large-scale evaluation of SLC18A2 in prostate cancer reveals diagnostic and prognostic biomarker potential at three molecular levels.
Haldrup C, Lynnerup AS, Storebjerg TM, Vang S, Wild P, Visakorpi T, Arsov C, Schulz WA, Lindberg J, Grönberg H, Egevad L, Borre M, Ørntoft TF, Høyer S, Sørensen KD.
Mol Oncol. 2016 Jun;10(6):825-37. doi: 10.1016/j.molonc.2016.02.001. Epub 2016 Feb 9. PubMed
The Potential of MicroRNAs as Prostate Cancer Biomarkers.
Fabris L1, Ceder Y2, Chinnaiyan AM3, Jenster GW4, Sorensen KD5, Tomlins S3, Visakorpi T6, Calin GA7.
Eur Urol. 2016 Jan 21. pii: S0302-2838(16)00012-9. doi: 10.1016/j.eururo.2015.12.054. [Epub ahead of print] PubMed
Genomic Alterations in Liquid Biopsies from Patients with Bladder Cancer.
Birkenkamp-Demtröder K, Nordentoft I, Christensen E, Høyer S, Reinert T, Vang S, Borre M, Agerbæk M, Jensen JB, Ørntoft TF, Dyrskjøt L.
Eur Urol. 2016 Jan 20. pii: S0302-2838(16)00058-0. doi: 10.1016/j.eururo.2016.01.007. [Epub ahead of print] PubMed
Corrigendum: Common variants at 19p13 are associated with susceptibility to ovarian cancer.
Bolton KL, Tyrer J, Song H, Ramus SJ, Notaridou M, Jones C, Sher T, Gentry-Maharaj A, Wozniak E, Tsai YY, Weidhaas J, Paik D, Van Den Berg DJ, Stram DO, Pearce CL, Wu AH, Brewster W, Anton-Culver H, Ziogas A, Narod SA, Levine DA, Kaye SB, Brown R, Paul J, Flanagan J, Sieh W, McGuire V, Whittemore AS, Campbell I, Gore ME, Lissowska J, Yang HP, Medrek K, Gronwald J, Lubinski J, Jakubowska A, Le ND, Cook LS, Kelemen LE, Brooks-Wilson A, Massuger LF, Kiemeney LA, Aben KK, van Altena AM, Houlston R, Tomlinson I, Palmieri RT, Moorman PG, Schildkraut J, Iversen ES, Phelan C, Vierkant RA, Cunningham JM, Goode EL, Fridley BL, Kruger-Kjaer S, Blaeker J, Hogdall E, Hogdall C, Gross J, Karlan BY, Ness RB, Edwards RP, Odunsi K, Moyisch KB, Baker JA, Modugno F, Heikkinenen T, Butzow R, Nevanlinna H, Leminen A, Bogdanova N, Antonenkova N, Doerk T, Hillemanns P, Dürst M, Runnebaum I, Thompson PJ, Carney ME, Goodman MT, Lurie G, Wang-Gohrke S, Hein R, Chang-Claude J, Rossing MA, Cushing-Haugen KL, Doherty J, Chen C, Rafnar T, Besenbacher S, Sulem P, Stefansson K, Birrer MJ, Terry KL, Hernandez D, Cramer DW, Vergote I, Amant F, Lambrechts D, Despierre E, Fasching PA, Beckmann MW, Thiel FC, Ekici AB, Chen X; Australian Ovarian Cancer Study Group, Johnatty SE, Webb PM, Beesley J, Chanock S, Garcia-Closas M, Sellers T, Easton DF, Berchuck A, Chenevix-Trench G, Pharoah PD, Gayther SA.
Nat Genet. 2016 Jan;48(1):101. doi: 10.1038/ng0116-101b. No abstract available. PubMed
Prevalence of the HOXB13 G84E mutation in Danish men treated by radical prostatectomy and correlations with prostate cancer risk and aggressiveness.
Storebjerg TM, Høyer S, Kirkegaard P, Bro F; Lu Camp, Orntoft TF, Borre M, Sørensen KD.
BJU Int. 2016 Jan 18. doi: 10.1111/bju.13416. [Epub ahead of print] PubMed
PINCAGE: Probabilistic integration of cancer genomics data for perturbed gene identification and sample classification.
Świtnicki MP, Juul M, Madsen T, Sørensen KD, Pedersen JS.
Bioinformatics. 2016 Jan 6. pii: btv758. [Epub ahead of print] PubMed
2015
Whitehead B, Wu L, Hvam ML, Aslan H, Dong M, Dyrskjøt L, Ostenfeld MS, Moghimi SM, Howard KA.
Tumour exosomes display differential mechanical and complement activation properties dependent on malignant state: implications in endothelial leakiness.
J Extracell Vesicles. 2015 Dec 28;4:29685. doi: 10.3402/jev.v4.29685. eCollection 2015. PubMed
Gao S, Zou D, Mao L, Liu H, Song P, Chen Y, Zhao S, Gao C, Li X, Gao Z, Fang X, Yang H, Ørntoft TF, Sørensen KD, Bolund L.
BS-SNPer: SNP calling in Bisulfite-seq data.
Bioinformatics. 2015 Dec 15;31(24):4006-8. doi: 10.1093/bioinformatics/btv507. Epub 2015 Aug 28. PubMed
Mortensen MM, Høyer S, Lynnerup AS, Ørntoft TF, Sørensen KD, Borre M, Dyrskjøt L.
Expression profiling of prostate cancer tissue delineates genes associated with recurrence after prostatectomy.
Sci Rep. 2015 Nov 2;5:16018. doi: 10.1038/srep16018. PubMed
Mørk N, Kofod-Olsen E, Sørensen KB, Bach E, Ørntoft TF, Østergaard L, Paludan SR, Christiansen M, Mogensen TH.
Mutations in the TLR3 signaling pathway and beyond in adult patients with herpes simplex encephalitis.
Genes Immun. 2015 Dec;16(8):552-66. doi: 10.1038/gene.2015.46. Epub 2015 Oct 29. PubMed
Ørntoft MB, Nielsen HJ, Ørntoft TF, Andersen CL; Danish Study Group on Early Detection of Colorectal Cancer.
Performance of the colorectal cancer screening marker Sept9 is influenced by age, diabetes and arthritis: a nested case-control study.
BMC Cancer. 2015 Oct 29;15:819. doi: 10.1186/s12885-015-1832-6. PubMed
Strand SH, Hoyer S, Lynnerup AS, Haldrup C, Storebjerg TM, Borre M, Orntoft TF, Sorensen KD.
High levels of 5-hydroxymethylcytosine (5hmC) is an adverse predictor of biochemical recurrence after prostatectomy in ERG-negative prostate cancer.
Clin Epigenetics. 2015 Oct 15;7:111. doi: 10.1186/s13148-015-0146-5. eCollection 2015. PubMed
Andersen LL, Mørk N, Reinert LS, Kofod-Olsen E, Narita R, Jørgensen SE, Skipper KA, Höning K, Gad HH, Østergaard L, Ørntoft TF, Hornung V, Paludan SR, Mikkelsen JG, Fujita T, Christiansen M, Hartmann R, Mogensen TH.
Functional IRF3 deficiency in a patient with herpes simplex encephalitis.
J Exp Med. 2015 Aug 24;212(9):1371-9. doi: 10.1084/jem.20142274. Epub 2015 Jul 27. PubMed
Gao S, Zou D, Mao L, Zhou Q, Jia W, Huang Y, Zhao S, Chen G, Wu S, Li D, Xia F, Chen H, Chen M, Ørntoft TF, Bolund L, Sørensen KD.
SMAP: a streamlined methylation analysis pipeline for bisulfite sequencing.
Gigascience. 2015 Jul 1;4:29. doi: 10.1186/s13742-015-0070-9. eCollection 2015. PubMed
Amin Al Olama A, Benlloch S, Antoniou AC, Giles GG, Severi G, Neal D, Hamdy FC, Donovan JL, Muir K, Schleutker J, Henderson BE, Haiman C, Schumacher FR, Pashayan N, Pharoah PD, Ostrander EA, Stanford JL, Batra J, Clements JA, Chambers SK, Weischer M, Nordestgaard BG, Ingles SA, Sorensen KD, Orntoft TF, Park JY, Cybulski C, Maier C, Doerk T, Dickinson JL, Cannon-Albright L, Brenner H, Rebbeck TR, Zeigler-Johnson C, Habuchi T, Thibodeau SN, Cooney K, Chappuis PO, Hutter P, Kaneva RP, Foulkes WD, Zeegers MP, Lu YJ, Zhang HW, Stephenson R, Cox A, Southey MC, Spurdle AB, FitzGerald L, Leongamornlert D, Saunders E, Tymrakiewicz M, Guy M, Dadaev T, Little SJ, Govindasami K, Sawyer E, Wilkinson R, Herkommer K, Hopper JL, Lophatonanon A, Rinckleb AE, Kote-Jarai Z, Eeles RA, Easton DF.
Risk Analysis of Prostate Cancer in PRACTICAL, a Multinational Consortium, Using 25 Known Prostate Cancer Susceptibility Loci.
Cancer Epidemiol Biomarkers Prev. 2015 Jul;24(7):1121-9. doi: 10.1158/1055-9965.EPI-14-0317. Epub 2015 Apr 2. PubMed
AMPKα is critical for enhancing skeletal muscle fatty acid utilization during in vivo exercise in mice.
Fentz J, Kjøbsted R, Birk JB, Jordy AB, Jeppesen J, Thorsen K, Schjerling P, Kiens B, Jessen N, Viollet B, Wojtaszewski JF.
FASEB J. 2015 May;29(5):1725-38. doi: 10.1096/fj.14-266650. PubMed
Yáñez-Mó M, Siljander PR, Andreu Z, Zavec AB, Borràs FE, Buzas EI, Buzas K, Casal E, Cappello F, Carvalho J, Colás E, Cordeiro-da Silva A, Fais S, Falcon-Perez JM, Ghobrial IM, Giebel B, Gimona M, Graner M, Gursel I, Gursel M, Heegaard NH, Hendrix A, Kierulf P, Kokubun K, Kosanovic M, Kralj-Iglic V, Krämer-Albers EM, Laitinen S, Lässer C, Lener T, Ligeti E, Linē A, Lipps G, Llorente A, Lötvall J, Manček-Keber M, Marcilla A, Mittelbrunn M, Nazarenko I, Nolte-'t Hoen EN, Nyman TA, O'Driscoll L, Olivan M, Oliveira C, Pállinger É, Del Portillo HA, Reventós J, Rigau M, Rohde E, Sammar M, Sánchez-Madrid F, Santarém N, Schallmoser K, Ostenfeld MS, Stoorvogel W, Stukelj R, Van der Grein SG, Vasconcelos MH, Wauben MH, De Wever O.
Biological properties of extracellular vesicles and their physiological functions.
J Extracell Vesicles. 2015 May 14;4:27066. doi: 10.3402/jev.v4.27066. eCollection 2015.PubMed
Resveratrol ameliorates imiquimod-induced psoriasis-like skin inflammation in mice.
Kjær TN, Thorsen K, Jessen N, Stenderup K, Pedersen SB.
PLoS One. 2015 May 12;10(5):e0126599. doi: 10.1371/journal.pone.0126599. PubMed
Prolonged erythropoietin treatment does not impact gene expression in human skeletal muscle.
Christensen B, Nellemann B, Thorsen K, Nielsen MM, Pedersen SB, Ornstrup MJ, JØrgensen JO, Jessen N.
Muscle Nerve. 2015 Apr;51(4):554-61. doi: 10.1002/mus.24355. PubMed
Groth KA, Gaustadnes M, Thorsen K, Østergaard JR, Jensen UB, Gravholt CH, Andersen NH.
Difficulties in diagnosing Marfan syndrome using current FBN1 databases.
Genet Med. 2015 Mar 26. doi: 10.1038/gim.2015.32. [Epub ahead of print] PubMed
Reinert T, Schøler LV, Thomsen R, Tobiasen H, Vang S, Nordentoft I, Lamy P, Kannerup AS, Mortensen FV, Stribolt K, Hamilton-Dutoit S, Nielsen HJ, Laurberg S, Pallisgaard N, Pedersen JS, Ørntoft TF, Andersen CL.
Analysis of circulating tumour DNA to monitor disease burden following colorectal cancer surgery.
Gut. 2015 Feb 4. pii: gutjnl-2014-308859. doi: 10.1136/gutjnl-2014-308859. [Epub ahead of print] PubMed
Dinesen PT, Dal J, Gabrovska P, Gaustadnes M, Gravholt CH, Stals K, Denes J, Asa SL, Korbonits M, Jørgensen JO.
An unusual case of an ACTH-secreting macroadenoma with a germline variant in the aryl hydrocarbon receptor-interacting protein (AIP) gene.
Endocrinol Diabetes Metab Case Rep. 2015;2015:140105. doi: 10.1530/EDM-14-0105. Epub 2015 Jan 1. PubMed
2010 - 2014
2014
Chen LM, Chang M, Dai Y, Chai KX, Dyrskjøt L, Sanchez-Cabayo M, Szarvas T, Zwarthoff EC, Lokeswhar V, Jeronimo C, Parker AS, Ross S, Borre M, Orntoft TF, Jaeger T, Beukers W, Lopez LE, Henrique R, Young PR, Urquidi V, Goodison S, Rosser CJ.
External Validation of a Multiplex Urinary Protein Panel for the Detection of Bladder Cancer in a Multicenter Cohort.
Cancer Epidemiol Biomarkers Prev. 2014 Sep;23(9):1804-12. doi: 10.1158/1055-9965.EPI-14-0029. Epub 2014 Jun 11. PubMed
Christensen B, Nellemann B, Thorsen K, Nielsen MM, Pedersen SB, Ornstrup MJ, Jørgensen JO, Jessen N.
Prolonged erythropoietin treatment does not impact gene expression in human skeletal muscle.
Muscle Nerve. 2014 Aug 1. doi: 10.1002/mus.24355. [Epub ahead of print] PubMed
Christensen LL, Holm A, Rantala J, Kallioniemi O, Rasmussen MH, Ostenfeld MS, Dagnaes-Hansen F, Oster B, Schepeler T, Tobiasen H, Thorsen K, Sieber OM, Gibbs P, Lamy P, Hansen TF, Jakobsen A, Riising EM, Helin K, Lubinski J, Hagemann-Madsen R, Laurberg S, Orntoft TF, Andersen CL.
Functional Screening Identifies miRNAs Influencing Apoptosis and Proliferation in Colorectal Cancer.
PLoS One. 2014 Jun 3;9(6):e96767. doi: 10.1371/journal.pone.0096767. eCollection 2014.PubMed
Christiansen M1, Hedley PL, Theilade J, Stoevring B, Leren TP, Eschen O, Sørensen KM, Tybjærg-Hansen A, Ousager LB, Pedersen LN, Frikke-Schmidt R, Aidt FH, Hansen MG, Hansen J, Bloch Thomsen PE, Toft E, Henriksen FL, Bundgaard H, Jensen HK, Kanters JK.
Mutations in Danish patients with long QT syndrome and the identification of a large founder family with p.F29L in KCNH2.
BMC Med Genet. 2014 Mar 7;15(1):31. doi: 10.1186/1471-2350-15-31.PubMed
Dal J, Gaustadnes M, Kristensen K, Gravholt CH, Jørgensen JOL
[Genetic screening for mutations enables early diagnosis of pituitary adenomas.]
Ugeskrift for Læger, 2014, vol. 176, nr. 1, s. 54-57.PubMed
Gerlinger M, Catto JW, Orntoft TF, Real FX, Zwarthoff EC, Swanton C.
Intratumour Heterogeneity in Urologic Cancers: From Molecular Evidence to Clinical Implications.
Eur Urol. 2015 Apr;67(4):729-37. doi: 10.1016/j.eururo.2014.04.014. Epub 2014 May 2. Review.PubMed
Gingold H, Tehler D, Christoffersen NR, Nielsen MM, Asmar F, Kooistra SM, Christophersen NS, Christensen LL, Borre M, Sørensen KD, Andersen LD, Andersen CL, Hulleman E, Wurdinger T, Ralfkiær E, Helin K, Grønbæk K, Orntoft T, Waszak SM, Dahan O, Pedersen JS, Lund AH, Pilpel Y.
A dual program for translation regulation in cellular proliferation and differentiation.
Cell. 2014 Sep 11;158(6):1281-92. doi: 10.1016/j.cell.2014.08.011.PubMed
Hedegaard J, Thorsen K, Lund MK, Hein AM, Hamilton-Dutoit SJ, Vang S, Nordentoft I, Birkenkamp-Demtröder K, Kruhøffer M, Hager H, Knudsen B, Andersen CL, Sørensen KD, Pedersen JS, Orntoft TF, Dyrskjøt L.
Next-Generation Sequencing of RNA and DNA Isolated from Paired Fresh-Frozen and Formalin-Fixed Paraffin-Embedded Samples of Human Cancer and Normal Tissue.
PLoS One. 2014 May 30;9(5):e98187. doi: 10.1371/journal.pone.0098187. eCollection 2014.PubMed
JeppesenDK, Hvam ML, Primdahl-Bengtson B, Boysen AT, Whitehead B, Dyrskjøt L, OrntoftTF, Howard KA, Ostenfeld MS.
Comparative analysis of discrete exosome fractions obtained by differential centrifugation.
J Extracell Vesicles. 2014 Nov 6;3:25011. doi: 10.3402/jev.v3.25011. eCollection 2014.PubMed
Jeppesen DK, Nawrocki A, Jensen SG, Thorsen K, Whitehead B, Howard KA, Dyrskjøt L, Orntoft TF, Larsen MR, Ostenfeld MS.
Quantitative proteomics of fractionated membrane and lumen exosome proteins from isogenic metastatic and nonmetastatic bladder cancer cells reveal differential expression of EMT factors.
Proteomics. 2014 Mar;14(6):699-712. doi: 10.1002/pmic.201300452. Epub 2014 Feb 16.PubMed
Kristensen H, Haldrup C, Strand S, Mundbjerg K, Mortensen MM, Thorsen K, Ostenfeld MS, Wild PJ, Arsov C, Goering W, Visakorpi T, Egevad L, Lindberg J, Grönberg H, Høyer S, Borre M, Ørntoft TF, Sørensen KD.
Hypermethylation of the GABRE~miR-452~miR-224 promoter in prostate cancer predicts biochemical recurrence after radical prostatectomy.
Clin Cancer Res. 2014 Apr 15;20(8):2169-81. doi: 10.1158/1078-0432.CCR-13-2642.PubMed
Laurberg JR, Jensen JB, Schepeler T, Borre M, Orntoft TF, Dyrskjøt L.
High expression of GEM and EDNRA is associated with metastasis and poor outcome in patients with advanced bladder cancer.
BMC Cancer. 2014 Aug 30;14:638. doi: 10.1186/1471-2407-14-638.PubMed
Lopez-Serra P, Marcilla M, Villanueva A, Ramos-Fernandez A, Palau A, Leal L, Wahi JE, Setien-Baranda F, Szczesna K, Moutinho C, Martinez-Cardus A, Heyn H, Sandoval J, Puertas S, Vidal A, Sanjuan X, Martinez-Balibrea E, Viñals F, Perales JC, Bramsem JB, Ørntoft TF, Andersen CL, Tabernero J, McDermott U, Boxer MB, Vander Heiden MG, Albar JP, Esteller M.
A DERL3-associated defect in the degradation of SLC2A1 mediates the Warburg effect.
Nat Commun. 2014 Apr 3;5:3608. doi: 10.1038/ncomms4608.PubMed
Mortensen MM, Høyer S, Orntoft TF, Sørensen KD, Dyrskjøt L, Borre M.
High miR-449b expression in prostate cancer is associated with biochemical recurrence after radical prostatectomy.
BMC Cancer. 2014 Nov 21;14:859. doi: 10.1186/1471-2407-14-859.PubMed
Naeem H, Wong NC, Chatterton Z, Hong MK, Pedersen JS, Corcoran NM, Hovens CM, Macintyre G.
Reducing the risk of false discovery enabling identification of biologically significant genome-wide methylation status using the HumanMethylation450 array.
BMC Genomics. 2014 Jan 22;15:51. doi: 10.1186/1471-2164-15-51.PubMed
Nordentoft I, Lamy P, Birkenkamp-Demtröder K, Shumansky K, Vang S, Hornshøj H, Juul M, Villesen P, Hedegaard J, Roth A, Thorsen K, Høyer S, Borre M, Reinert T, Fristrup N, Dyrskjøt L, Shah S, Pedersen JS, Orntoft TF.
Mutational Context and Diverse Clonal Development in Early and Late Bladder Cancer.
Cell Rep. 2014 May 14. pii: S2211-1247(14)00340-4. doi: 10.1016/j.celrep.2014.04.038. [Epub ahead of print] PubMed
Ongen H, Andersen CL, Bramsen JB, Oster B, Rasmussen MH, Ferreira PG, Sandoval J, Vidal E, Whiffin N, Planchon A, Padioleau I, Bielser D, Romano L, Tomlinson I, Houlston RS, Esteller M, Orntoft TF, Dermitzakis ET.
Putative cis-regulatory drivers in colorectal cancer.
Nature. 2014 Aug 7;512(7512):87-90. doi: 10.1038/nature13602. Epub 2014 Jul 23.PubMed
Orntoft TF, Nielsen FC.
[Molekylær medicin og den dybe sekventering]
Ugeskr Laeger. 2014 Jun 2;176(11A). pii: V66258. Danish. No abstract available.PubMed
Ostenfeld MS, Jeppesen DK, Laurberg JR, Boysen AT, Bramsen JB, Primdal-Bengtson B, Lamy P, Dagnaes-Hansen F, Bui KH, Fristrup N, Christensen EI,
Morth JP, Jensen JB, Pedersen JS, Beck M, Theodorescu D, Borre M, Howard KA, Dyrskjøt L, Ørntoft TF
Cellular disposal of miR-23b by Rab27a/ b-dependent exosome release is linked to acquisition of metastatic properties.
Cancer Res. 2014 Oct 15;74(20):5758-71. doi: 10.1158/0008-5472.CAN-13-3512. Epub 2014 Sep 26. PubMed
Peng H1, Talebzadeh-Farrooji M, Osborne MJ, Prokop JW, McDonald PC, Karar J, Hou Z, He M, Kebebew E, Orntoft T, Herlyn M, Caton AJ, Fredericks W,Malkowicz B, Paterno CS, Carolin AS, Speicher DW, Skordalakes E, Huang Q, Dedhar S, Borden KL, Rauscher FJ 3rd.
LIMD2 Is a Small LIM-Only Protein Overexpressed in Metastatic Lesions That Regulates Cell Motility and TumorProgression by Directly Binding to and Activating the Integrin-Linked Kinase.
Cancer Res. 2014 Mar 1;74(5):1390-403. doi: 10.1158/0008-5472.CAN-13-1275.PubMed
Strand SH, Orntoft TF, Sorensen KD.
Prognostic DNA Methylation Markers for Prostate Cancer.
Int J Mol Sci. 2014 Sep 18;15(9):16544-76. doi: 10.3390/ijms150916544. Review.PubMed
Teo MT, Dyrskjøt L, Nsengimana J, Buchwald C, Snowden H, Morgan J, Jensen JB, Knowles MA, Taylor G, Barrett JH, Borre M, Orntoft TF, Bishop DT, Kiltie AE.
Next-generation sequencing identifies germline MRE11A variants as markers of radiotherapy outcomes in muscle-invasive bladder cancer.
Ann Oncol. 2014 Apr;25(4):877-83. doi: 10.1093/annonc/mdu014. Epub 2014 Mar 12.PubMed
Vedder MM, Márquez M, de Bekker-Grob EW, Calle ML, Dyrskjøt L, Kogevinas M, Segersten U, Malmström PU, Algaba F, Beukers W, Orntoft TF, Zwarthoff E, Real FX, Malats N, Steyerberg EW.
Risk Prediction Scores for Recurrence and Progression of Non-Muscle Invasive Bladder Cancer: An International Validation in Primary Tumours.
PLoS One. 2014 Jun 6;9(6):e96849. doi: 10.1371/journal.pone.0096849. eCollection 2014.PubMed
Wesołowska-Andersen A, Borst L, Dalgaard MD, Yadav R, Rasmussen KK, Wehner PS, Rasmussen M, Orntoft TF, Nordentoft I, Koehler R, Bartram CR, Schrappe M, Sicheritz-Ponten T, Gautier L, Marquart H, Madsen HO, Brunak S, Stanulla M, Gupta R, Schmiegelow K.
Genomic profiling of thousands of candidate polymorphisms predicts risk of relapse in 778 Danish and German childhood acute lymphoblastic leukemia patients.
Leukemia. 2015 Feb;29(2):297-303. doi: 10.1038/leu.2014.205. Epub 2014 Jul 3. [Epub ahead of print]PubMed
2013
Allory Y, Beukers W, Sagrera A, Flández M, Marqués M, Márquez M, van der Keur KA, Dyrskjot L, Lurkin I, Vermeij M, Carrato A, Lloreta J, Lorente JA, Carrillo-de Santa Pau E, Masius RG, Kogevinas M, Steyerberg EW, van Tilborg AA, Abas C, Orntoft TF, Zuiverloon TC, Malats N, Zwarthoff EC, Real FX.
Telomerase Reverse Transcriptase Promoter Mutations in Bladder Cancer: High Frequency Across Stages, Detection in Urine, and Lack of Association with Outcome.
Eur Urol. 2013 Sep 6. doi:pii: S0302-2838(13)00904-4. 10.1016/j.eururo.2013.08.052. [Epub ahead of print] PubMed
Beukers W, Kandimalla R, van Houwelingen D, Kovacic H, Chin JF, Lingsma HF, Dyrskjot L, Zwarthoff EC.
The use of molecular analyses in voided urine for the assessment of patients with hematuria.
PLoS One. 2013 Oct 15;8(10):e77657. doi: 10.1371/journal.pone.0077657. PubMed
Birkenkamp-Demtröder K, Hahn SA, Mansilla F, Thorsen K, Maghnouj A, Christensen R, Oster B, Orntoft TF.
Keratin23 (KRT23) Knockdown Decreases Proliferation and Affects the DNA Damage Response of Colon Cancer Cells.
PLoS One. 2013 Sep 9;8(9):e73593. doi: 10.1371/journal.pone.0073593. PubMed
Birkenkamp-Demtröder, K., Mansilla, F., Andersen, L. D., Thorsen, K., Fristrup, N., Brems-Eskildsen, A. S., Madsen, P. P., Sørensen, K. D., Borre, M. & Ørntoft, T. F.
TOX3 (TNRC9) overexpression in bladder cancer cells decreases cellular proliferation and triggers an interferon-like response.
Journal of Molecular Biomarkers & Diagnosis. 4, 1, jan 2013
Børglum AD, Demontis D, Grove J, Pallesen J, Hollegaard MV, Pedersen CB, Hedemand A, Mattheisen M; GROUP investigators, Uitterlinden A, Nyegaard M, Orntoft T, Wiuf C, Didriksen M, Nordentoft M, Nöthen MM, Rietschel M, Ophoff RA, Cichon S, Yolken RH, Hougaard DM, Mortensen PB, Mors O.
Genome-wide study of association and interaction with maternal cytomegalovirus infection suggests new schizophrenia loci.
Mol Psychiatry. 2014 Mar;19(3):325-33. doi: 10.1038/mp.2013.2. Epub 2013 Jan 29. PubMed
Christensen LL, Tobiasen H, Holm A, Schepeler T, Ostenfeld MS, Thorsen K, Rasmussen MH, Birkenkamp-Demtroeder K, Sieber OM, Gibbs P, Lubinski J, Lamy P; COLOFOL steering group, Laurberg S, Oster B, Hansen KQ, Hagemann-Madsen R, Byskov K, Orntoft TF, Andersen CL.
MiRNA-362-3p induces cell cycle arrest through targeting of E2F1, USF2 and PTPN1 and is associated with recurrence of colorectal cancer.
Int J Cancer. 2013 Jul;133(1):67-78. doi: 10.1002/ijc.28010. Epub 2013 Feb 12. PubMed
Clasen BF, Krusenstjerna-Hafstrøm T, Vendelbo MH, Thorsen K, Escande C, Møller N, Pedersen SB, Jørgensen JO, Jessen N.
Gene expression in skeletal muscle after an acute intravenous GH bolus in human subjects: identification of a mechanism regulating ANGPTL4.
J Lipid Res. 2013 Jul;54(7):1988-97. doi: 10.1194/jlr.P034520. PubMed
Cohen-Eliav M, Golan-Gerstl R, Siegfried Z, Andersen CL, Thorsen K, Ørntoft TF, Mu D, Karni R.
The splicing factor SRSF6 is amplified and is an oncoprotein in lung and colon cancers.
J Pathol. 2013 Mar;229(4):630-9. doi: 10.1002/path.4129. PubMed
Dal J, Gaustadnes M, Kristensen K, Gravholt CH, Jørgensen JO.
[Genetic screening for mutations enables early diagnosis of pituitary tumors]
Ugeskr Laeger. Danish. preprint 2013
Evangelou K, Bartkova J, Kotsinas A, Pateras IS, Liontos M, Velimezi G, Kosar M, Liloglou T, Trougakos IP, Dyrskjot L, Andersen CL, Papaioannou M, Drosos Y, Papafotiou G, Hodny Z, Sosa-Pineda B, Wu XR, Klinakis A, Orntoft T, Lukas J, Bartek J, Gorgoulis VG.
The DNA damage checkpoint precedes activation of ARF in response to escalating oncogenic stress during tumorigenesis.
Cell Death Differ. 2013 Jul 12. doi: 10.1038/cdd.2013.76. [Epub ahead of print] PubMed
Haldrup C, Mundbjerg K, Vestergaard EM, Lamy P, Wild P, Schulz WA, Arsov C, Visakorpi T, Borre M, Høyer S, Orntoft TF, Sørensen KD.
DNA Methylation Signatures for Prediction of Biochemical Recurrence After Radical Prostatectomy of Clinically Localized Prostate Cancer.
J Clin Oncol. 2013 Sep 10;31(26):3250-8. doi: 10.1200/JCO.2012.47.1847. Epub 2013 Aug 5. PubMed
Jeppesen DK, Nawrocki A, Jensen SG, Thorsen K, Whitehead B, Howard KA, Dyrskjøt L, Orntoft TF, Larsen MR, Ostenfeld MS.
Quantitative proteomics of fractionated membrane and lumen exosome proteins from isogenic metastatic and non-metastatic bladder cancer cells reveal differential expression of EMT factors.
Proteomics. 2013 Dec 26. doi: 10.1002/pmic.201300452. [Epub ahead of print] PubMed
Jeppesen J, Maarbjerg SJ, Jordy AB, Fritzen AM, Pehmøller C, Sylow L, Serup AK, Jessen N, Thorsen K, Prats C, Qvortrup K, Dyck JR, Hunter RW, Sakamoto K, Thomson DM, Schjerling P, Wojtaszewski JF, Richter EA, Kiens B.
LKB1 regulates lipid oxidation during exercise independently of AMPK.
Diabetes. 2013 May;62(5):1490-9. doi: 10.2337/db12-1160. PubMed
Kandimalla R, Masius R, Beukers W, Bangma CH, Orntoft TF, Dyrskjøt L, Leeuwen NV, Lingsma HF, van Tilborg AA, Zwarthoff EC.
A 3-plex methylation assay combined with the FGFR3 mutation assay sensitively detects recurrent bladder cancer in voided urine.
Clin Cancer Res. 2013 Sep 1;19(17):4760-9. doi: 10.1158/1078-0432.CCR-12-3276. Epub 2013 Jul 10.PubMed
Nielsen MM, Tehler D, Vang S, Sudzina F, Hedegaard J, Nordentoft I, Orntoft TF, Lund AH, Pedersen JS.
Identification of expressed and conserved human noncoding RNAs.
RNA. 2014 Feb;20(2):236-51. doi: 10.1261/rna.038927.113. Epub 2013 Dec 16. PubMed
Pedersen JS, Valen E, Velazquez AM, Parker BJ, Rasmussen M, Lindgreen S, Lilje B, Tobin DJ, Kelly TK, Vang S, Andersson R, Jones PA, Hoover CA, Tikhonov A, Prokhortchouk E, Rubin EM, Sandelin A, Gilbert MT, Krogh A, Willerslev E, Orlando L.
Genome-wide nucleosome map and cytosine methylation levels of an ancient human genome.
Genome Res. 2014 Mar;24(3):454-66. doi: 10.1101/gr.163592.113. Epub 2013 Dec 3. PubMed
Rasmussen MH, Jensen NF, Tarpgaard LS, Qvortrup C, Rømer MU, Stenvang J, Hansen TP, Christensen LL, Lindebjerg J, Hansen F, Jensen BV, Hansen TF, Pfeiffer P, Brünner N, Orntoft TF, Andersen CL.
High expression of microRNA-625-3p is associated with poor response to first-line oxaliplatin based treatment of metastatic colorectal cancer.
Mol Oncol. 2013 Jun;7(3):637-46. doi: 10.1016/j.molonc.2013.02.016. Epub 2013 Feb 28. PubMed
Sørensen KD, Abildgaard MO, Haldrup C, Ulhøi BP, Kristensen H, Strand S, Parker C, Høyer S, Borre M, Orntoft TF.
Prognostic significance of aberrantly silenced ANPEP expression in prostate cancer.
Br J Cancer. 2013 Feb 5;108(2):420-8. doi: 10.1038/bjc.2012.549. Epub 2013 Jan 15. PubMed
Long QT Interval in Turner Syndrome - A High Prevalence of LQTS Gene Mutations.
PLoS One. 2013 Jul 25;8(7):e69614. doi: 10.1371/journal.pone.0069614. Print 2013. PubMed
Ørntoft TF.
[New scientific society--Danish Society for Molecular Medicine--established in spring 2012].
Ugeskr Laeger. 2013 Mar 18;175(12):813. Danish. No abstract available. PubMed
2012
Al Olama AA, Kote-Jarai Z, Schumacher FR, Wiklund F, Berndt SI, Benlloch S, Giles GG, Severi G, Neal DE, Hamdy FC, Donovan JL, Hunter DJ, Henderson BE, Thun MJ, Gaziano M, Giovannucci EL, Siddiq A, Travis RC, Cox DG, Canzian F, Riboli E, Key TJ, Andriole G, Albanes D, Hayes RB, Schleutker J, Auvinen A, Tammela TL, Weischer M, Stanford JL, Ostrander EA, Cybulski C, Lubinski J, Thibodeau SN, Schaid DJ, Sorensen KD, Batra J, Clements JA, Chambers S, Aitken J, Gardiner RA, Maier C, Vogel W, Dörk T, Brenner H, Habuchi T, Ingles S, John EM, Dickinson JL, Cannon-Albright L, Teixeira MR, Kaneva R, Zhang HW, Lu YJ, Park JY, Cooney KA, Muir KR, Leongamornlert DA, Saunders E, Tymrakiewicz M, Mahmud N, Guy M, Govindasami K, O'Brien LT, Wilkinson RA, Hall AL, Sawyer EJ, Dadaev T, Morrison J, Dearnaley DP, Horwich A, Huddart RA, Khoo VS, Parker CC, Van As N, Woodhouse CJ, Thompson A, Dudderidge T, Ogden C, Cooper CS, Lophatonanon A, Southey MC, Hopper JL, English D, Virtamo J, Le Marchand L, Campa D, Kaaks R, Lindstrom S, Diver WR, Gapstur S, Yeager M, Cox A, Stern MC, Corral R, Aly M, Isaacs W, Adolfsson J, Xu J, Zheng SL, Wahlfors T, Taari K, Kujala P, Klarskov P, Nordestgaard BG, Røder MA, Frikke-Schmidt R, Bojesen SE, Fitzgerald LM, Kolb S, Kwon EM, Karyadi DM, Orntoft TF, Borre M, Rinckleb A, Luedeke M, Herkommer K, Meyer A, Serth J, Marthick JR, Patterson B, Wokolorczyk D, Spurdle A, Lose F, McDonnell SK, Joshi AD, Shahabi A, Pinto P, Santos J, Ray A, Sellers TA, Lin HY, Stephenson RA, Teerlink C, Muller H, Rothenbacher D, Tsuchiya N, Narita S, Cao GW, Slavov C, Mitev V; The UK Genetic Prostate Cancer Study Collaborators/British Association of Urological Surgeons' Section of Oncology; The UK ProtecT Study Collaborators; The Australian Prostate Cancer Bioresource; The PRACTICAL Consortium, Chanock S, Gronberg H, Haiman CA, Kraft P, Easton DF, Eeles RA.
A meta-analysis of genome-wide association studies to identify prostate cancer susceptibility loci associated with aggressive and non-aggressive disease.
Hum Mol Genet. 2013 Jan 15;22(2):408-415. Epub 2012 Oct 12. PubMed
Baraniskin A, Nöpel-Dünnebacke S, Ahrens M, Jensen SG, Zöllner H, Maghnouj A, Wos A, Mayerle J, Munding J, Kost D, Reinacher-Schick A, Liffers S, Schroers R, Chromik AM, Meyer HE, Uhl W, Klein-Scory S, Weiss FU, Stephan C, Schwarte-Waldhoff I, Lerch MM, Tannapfel A, Schmiegel W, Andersen CL, Hahn SA.
Circulating U2 small nuclear RNA fragments as a novel diagnostic biomarker for pancreatic and colorectal adenocarcinoma.
Int J Cancer. 2013 Jan 15;132(2):E48-57. doi: 10.1002/ijc.27791. Epub 2012 Sep 14. PubMed
Baraniskin A, Birkenkamp-Demtroder K, Maghnouj A, Zöllner H, Munding J, Klein-Scory S, Reinacher-Schick A, Schwarte-Waldhoff I, Schmiegel W, Hahn SA.
MiR-30a-5p suppresses tumor growth in colon carcinoma by targeting DTL.
Carcinogenesis. 2012 Feb 27. [Epub ahead of print]. PubMed
Bentzon DN, Nyegaard M,Børglum A, Ørntoft T, Borre M, Sørensen KD
Replication of Prostate Cancer Risk Variants in a Danish Case-Control Association Study
Open Journal of Urology, 2012, 2, 45-54 doi:10.4236/oju.2012.22009 Published Online May 2012 (http://www.SciRP.org/journal/oju)
Christensen LL, Tobiasen H, Holm A, Schepeler T, Ostenfeld MS, Thorsen K, Rasmussen MH, Birkenkamp-Demtroeder K, Sieber OM, Gibbs P, Lubinski J, Lamy P; On behalf of the COLOFOL steering group Søren Laurberg, Oster B, Hansen KQ, Hagemann-Madsen R, Byskov K, Orntoft TF, Andersen CL; The first authorship is shared by Lise Lotte Christensen and Heidi Tobiasen.MiRNA-362-3p induces cell cycle arrest through targeting of E2F1, USF2 and PTPN1 and is associated with recurrence of colorectal cancer.
Int J Cancer. 2012 Dec 30. doi: 10.1002/ijc.28010. [Epub ahead of print] PubMed
Christiansen A, Dyrskjøt L.
The functional role of the novel biomarker karyopherin α 2 (KPNA2) in cancer.
Cancer Lett. 2013 Apr 30;331(1):18-23. doi: 10.1016/j.canlet.2012.12.013. Epub 2012 Dec 23. Review. PubMed
Cohen-Eliav M, Golan-Gerstl R, Siegfried Z, Andersen CL, Thorsen K, Orntoft TF, Mu D, Karni R.
The splicing factor SRSF6 is amplified and is an oncoprotein in lung and colon cancers.
J Pathol. 2012 Nov 6. doi: 10.1002/path.4129. [Epub ahead of print] PubMed
Dallosso AR, Oster B, Greenhough A, Thorsen K, Curry TJ, Owen C, Hancock AL, Szemes M, Paraskeva C, Frank M, Andersen CL, Malik K.
Long-range epigenetic silencing of chromosome 5q31 protocadherins is involved in early and late stages of colorectal tumorigenesis through modulation of oncogenic pathways.
Oncogene. 2012 Jan 16. doi: 10.1038/onc.2011.609. [Epub ahead of print] PubMed
Dyrskjøt L, Reinert T, Novoradovsky A, Zuiverloon TC, Beukers W, Zwarthoff E, Malats N, Real FX, Segersten U, Malmström PU, Knowles M, Hurst C, Sorge J, Borre M, Orntoft TF.
Analysis of molecular intra-patient variation and delineation of a prognostic 12-gene signature in non-muscle invasive bladder cancer; technology transfer from microarrays to PCR.
Br J Cancer. 2012 Oct 9;107(8):1392-8. doi: 10.1038/bjc.2012.412. Epub 2012 Sep 13. PubMed
Dyrskjøt L, Zieger K, Kissow Lildal T, Reinert T, Gruselle O, Coche T, Borre M, Orntoft TF.
Expression of MAGE-A3, NY-ESO-1, LAGE-1 and PRAME in urothelial carcinoma.
Br J Cancer. 2012 Jun 26;107(1):116-22. doi: 10.1038/bjc.2012.215. Epub 2012 May 17. PubMed
Fristrup N, Birkenkamp-Demtröder K, Reinert T, Sanchez-Carbayo M, Segersten U, Malmström PU, Palou J, Alvarez-Múgica M, Pan CC, Ulhøi BP, Borre M, Orntoft TF, Dyrskjøt L.
Multicenter Validation of Cyclin D1, MCM7, TRIM29, and UBE2C as Prognostic Protein Markers in Non-Muscle Invasive Bladder Cancer.
Am J Pathol. 2013 Feb;182(2):339-49. doi: 10.1016/j.ajpath.2012.10.017. Epub 2012 Nov 28. PubMed
Fristrup N, Ulhøi BP, Birkenkamp-Demtröder K, Mansilla F, Sanchez-Carbayo M, Segersten U, Malmström PU, Hartmann A, Palou J, Alvarez-Múgica M, Zieger K, Borre M, Orntoft TF, Dyrskjøt L.Cathepsin E, Maspin, Plk1, and Survivin Are Promising Prognostic Protein Markers for Progression in Non-Muscle Invasive Bladder Cancer.
Am J Pathol. 2012 May;180(5):1824-34. Epub 2012 Mar 24. PubMed
Gurzov EN, Barthson J, Marhfour I, Ortis F, Naamane N, Igoillo-Esteve M, Gysemans C, Mathieu C, Kitajima S, Marchetti P, Ørntoft TF, Bakiri L, Wagner EF, Eizirik DL.
Pancreatic β-cells activate a JunB/ATF3-dependent survival pathway during inflammation.
Oncogene. 2012 Mar 29;31(13):1723-32. doi: 10.1038/onc.2011.353. Epub 2011 Aug 15. PubMed
Laurberg JR, Brems-Eskildsen AS, Nordentoft I, Fristrup N, Schepeler T, Ulhøi BP, Agerbaek M, Hartmann A, Bertz S, Wittlinger M, Fietkau R, Rödel C, Borre M, Jensen JB, Orntoft T, Dyrskjøt L.
Expression of TIP60 (tat-interactive protein) and MRE11 (meiotic recombination 11 homolog) predict treatment-specific outcome of localised invasive bladder cancer.
BJU Int. 2012 Oct 9. doi: 10.1111/j.1464-410X.2012.11564.x. [Epub ahead of print] PubMed
Maniecki MB, Etzerodt A, Ulhøi BP, Steiniche T, Borre M, Dyrskjøt L, Orntoft TF, Moestrup SK, Møller HJ.Tumor-promoting macrophages induce the expression of the macrophage-specific receptor CD163 in malignant cells. Int J Cancer. 2012 Nov 15;131(10):2320-31. doi: 10.1002/ijc.27506. Epub 2012 Mar 28. PubMed
Nordentoft I, Birkenkamp-Demtroder K, Agerbæk M, Theodorescu D, Ostenfeld MS, Hartmann A, Borre M, Orntoft TF, Dyrskjøt L.
miRNAs associated with chemo-sensitivity in cell lines and in advanced bladder cancer.
BMC Med Genomics. 2012 Sep 6;5(1):40. [Epub ahead of print] PubMed
Oster B, Linnet L, Christensen LL, Thorsen K, Ongen H, Dermitzakis ET, Sandoval J, Moran S, Esteller M, Hansen TF, Lamy P; On behalf of the COLOFOL steering group, Laurberg S, Orntoft TF, Andersen CL.
Non-CpG island promoter hypomethylation and miR-149 regulate the expression of SRPX2 in colorectal cancer.
Int J Cancer. 2012 Nov 1. doi: 10.1002/ijc.27921. [Epub ahead of print] PubMed
Pandha H, Sorensen KD, Orntoft TF, Langley S, Hoyer S, Borre M, Morgan R.
Urinary engrailed-2 (EN2) levels predict tumour volume in men undergoing radical prostatectomy for prostate cancer.
BJU Int. 2012 Sep;110(6 Pt B):E287-92. doi: 10.1111/j.1464-410X.2012.11208.x. Epub 2012 May 15. PubMed
Reid AH, Attard G, Brewer D, Miranda S, Riisnaes R, Clark J, Hylands L, Merson S, Vergis R, Jameson C, Høyer S, Sørensen KD, Borre M, Jones C, de Bono JS, Cooper CS.
Novel, gross chromosomal alterations involving PTEN cooperate with allelic loss in prostate cancer.
Mod Pathol. 2012 Mar 30. doi: 10.1038/modpathol.2011.207. [Epub ahead of print] PubMed
Reinert T, Borre M, Christiansen A, Hermann GG, Orntoft TF, Dyrskjøt L.
Diagnosis of Bladder Cancer Recurrence Based on Urinary Levels of EOMES, HOXA9, POU4F2, TWIST1, VIM, and ZNF154 Hypermethylation.
PLoS One. 2012;7(10):e46297. doi: 10.1371/journal.pone.0046297. Epub 2012 Oct 3. PubMed
Schepeler T, Lamy P, Laurberg JR, Fristrup N, Reinert T, Bartkova J, Tropia L, Bartek J, Halazonetis TD, Pan CC, Borre M, Dyrskjøt L, Orntoft TF.
A high resolution genomic portrait of bladder cancer: correlation between genomic aberrations and the DNA damage response.
Oncogene. 2012 Aug 27. doi: 10.1038/onc.2012.381. [Epub ahead of print] PubMed
Steinberg S, de Jong S, Mattheisen M, Costas J, Demontis D, Jamain S, Pietiläinen OP, Lin K, Papiol S, Huttenlocher J, Sigurdsson E, Vassos E, Giegling I, Breuer R, Fraser G, Walker N, Melle I, Djurovic S, Agartz I, Tuulio-Henriksson A, Suvisaari J, Lönnqvist J, Paunio T, Olsen L, Hansen T, Ingason A, Pirinen M, Strengman E; GROUP, Hougaard DM, Orntoft T, Didriksen M, Hollegaard MV, Nordentoft M, Abramova L, Kaleda V, Arrojo M, Sanjuán J, Arango C, Etain B, Bellivier F, Méary A, Schürhoff F, Szoke A, Ribolsi M, Magni V, Siracusano A, Sperling S, Rossner M, Christiansen C, Kiemeney LA, Franke B, van den Berg LH, Veldink J, Curran S, Bolton P, Poot M, Staal W, Rehnstrom K, Kilpinen H, Freitag CM, Meyer J, Magnusson P, Saemundsen E, Martsenkovsky I, Bikshaieva I, Martsenkovska I, Vashchenko O, Raleva M, Paketchieva K, Stefanovski B, Durmishi N, Pejovic Milovancevic M, Lecic Tosevski D, Silagadze T, Naneishvili N, Mikeladze N, Surguladze S, Vincent JB, Farmer A, Mitchell PB, Wright A, Schofield PR, Fullerton JM, Montgomery GW, Martin NG, Rubino IA, van Winkel R, Kenis G, De Hert M, Réthelyi JM, Bitter I, Terenius L, Jönsson EG, Bakker S, van Os J, Jablensky A, Leboyer M, Bramon E, Powell J, Murray R, Corvin A, Gill M, Morris D, O'Neill FA, Kendler K, Riley B; Wellcome Trust Case Control Consortium 2, Craddock N, Owen MJ, O'Donovan MC, Thorsteinsdottir U, Kong A, Ehrenreich H, Carracedo A, Golimbet V, Andreassen OA, Børglum AD, Mors O, Mortensen PB, Werge T, Ophoff RA, Nöthen MM, Rietschel M, Cichon S, Ruggeri M, Tosato S, Palotie A, St Clair D, Rujescu D, Collier DA, Stefansson H, Stefansson K.
Common variant at 16p11.2 conferring risk of psychosis.
Mol Psychiatry. 2014 Jan;19(1):108-14. doi: 10.1038/mp.2012.157. Epub 2012 Nov 20. PubMed
Sørensen KD.
Predicting the future of advanced prostate cancer.
Lancet Oncol. 2012 Nov;13(11):1067-8. doi: 10.1016/S1470-2045(12)70398-4. Epub 2012 Oct 9. PubMed
van Tilborg AA, Kompier LC, Lurkin I, Poort R, El Bouazzaoui S, van der Keur K, Zuiverloon T, Dyrskjot L, Orntoft TF, Roobol MJ, Zwarthoff EC.
Selection of Microsatellite Markers for Bladder Cancer Diagnosis without the Need for Corresponding Blood.
PLoS One. 2012;7(8):e43345. doi: 10.1371/journal.pone.0043345. Epub 2012 Aug 22. PubMed
Zuiverloon TC, Beukers W, van der Keur KA, Nieuweboer AJ, Reinert T, Dyrskjot L, Orntoft TF, Zwarthoff EC.
Combinations of urinary biomarkers for surveillance of patients with incident non-muscle invasive bladder cancer: The European FP7 UROMOL Project.
J Urol. 2013 May;189(5):1945-51. doi: 10.1016/j.juro.2012.11.115. Epub 2012 Nov 28. PubMed
2011
Abildgaard MO, Borre M, Mørck Mortensen M, Ulhøi BP, Tørring N, Wild P, Kristensen H, Mansilla F, Ottosen PD, Dyrskjøt L, Orntoft TF, Dalsgaard Sørensen K.
Downregulation of ZNF132 in prostate cancer is associated with aberrant promoter hypermethylation and poor prognosis.
Int J Cancer. 2012 Feb 15;130(4):885-95. doi: 10.1002/ijc.26097. Epub 2011 May 25. PubMed
Alhopuro P, Sammalkorpi H, Niittymäki I, Biström M, Raitila A, Saharinen J, Nousiainen K, Lehtonen HJ, Heliövaara E, Puhakka J, Tuupanen S, Sousa S, Seruca R, Ferreira AM, Hofstra RM, Mecklin JP, Järvinen H, Ristimäki A, Orntoft TF, Hautaniemi S, Arango D, Karhu A, Aaltonen LA.
Candidate driver genes in microsatellite-unstable colorectal cancer.
Int J Cancer. 2011 May 4. doi: 10.1002/ijc.26167. [Epub ahead of print] PubMed
Andersen CL, Lamy P, Orntoft TF.
Are CIMP and chr16p13.2 copy number status independent prognostic markers in stage II and III colorectal cancer? Int J Cancer. 2012 Jan 1;130(1):243. doi: 10.1002/ijc.25998. Epub 2011 Apr 25. PubMed
Andersen CL, Lamy P, Thorsen K, Kjeldsen E, Wikman F, Villesen P, Øster B, Laurberg S, Ørntoft TF.
Frequent genomic loss at chr16p13.2 is associated with poor prognosis in colorectal cancer.
Int J Cancer. 2011 Oct 15;129(8):1848-58. doi: 10.1002/ijc.25841. Epub 2011 Mar 11. PubMed
Baandrup JD, Markvardsen LH, Peters CD, Schou UK, Jensen JL, Magnusson NE, Orntoft TF, Kruhøffer M, Simonsen U.
Pressure load: the main factor for altered gene expression in right ventricular hypertrophy in chronic hypoxic rats.
PLoS One. 2011 Jan 5;6(1):e15859. PubMed
Birkenkamp-Demtroder K, Maghnouj A, Mansilla F, Thorsen K, Andersen CL, Øster B, Hahn S and Ørntoft TF.
Repression of KIAA1199 attenuates Wnt-signalling and decreases the proliferation of colon cancer cells.
Br J Cancer. 2011 Jul 19. doi: 10.1038/bjc.2011.268. [Epub ahead of print] PubMed
Hansen TF, Andersen CL, Nielsen BS, Spindler KLG, Sørensen FB, Lindebjerg J, Brandslund I, Jakobsen A.
Elevated microRNA-126 is associated with high vascular endothelial growth factor receptor 2 expression levels and high microvessel density in colorectal cancer.
Oncology Letters. 2011. Epub Aug 4. doi
Henriksen R, Sørensen FB, Orntoft TF, Birkenkamp-Demtroder K.
Expression of FK506 binding protein 65 (FKBP65) is decreased in epithelial ovarian cancer cells compared to benign tumor cells and to ovarian epithelium.
Tumour Biol. 2011 Aug;32(4):671-6. Epub 2011 Mar 12. PubMed
Hollegaard MV, Grove J, Grauholm J, Kreiner-Møller E, Bønnelykke K, Nørgaard M, Benfield TL, Nørgaard-Pedersen B, Mortensen PB, Mors O, Sørensen HT, Harboe ZB, Børglum AD, Demontis D, Ørntoft TF, Bisgaard H, Hougaard DM.
Robustness of genome-wide scanning using archived dried blood spot samples as a DNA source.
BMC Genet. 2011 Jul 4;12:58. PubMed
Jensen JB, Munksgaard PP, Sørensen CM, Fristrup N, Birkenkamp-Demtroder K, Ulhøi BP, Jensen KM, Orntoft TF, Dyrskjøt L.
High Expression of Karyopherin-α2 Defines Poor Prognosis in Non-Muscle-Invasive Bladder Cancer and in Patients with Invasive Bladder Cancer Undergoing Radical Cystectomy.
Eur Urol. 2011 Feb 15. [Epub ahead of print] PubMed
Jensen SG, Lamy P, Rasmussen MH, Ostenfeld MS, Dyrskjot L, Orntoft TF, Andersen CL.
Evaluation of two commercial global miRNA expression profiling platforms for detection of less abundant miRNAs. BMC Genomics. 2011 Aug 26;12(1):435. PubMed
Zsofia Kote-Jarai, Ali Amin Al Olama, Graham G. Giles,, Gianluca Severi,, Johanna Schleutker, Maren Weischer, Frederico Canzian, Elio Riboli,,Tim Key, Henrik Gronberg, David J.Hunter, Peter Kraft, Michael J Thun, Sue Ingles, Stephen Chanock, Demetrius Albanes, Richard B Hayes, David E. Neal, Freddie C. Hamdy, Jenny L. Donovan, Paul Pharoah, Fredrick Schumacher, Brian E. Henderson, Janet L. Stanford , Elaine A. Ostrander, Karina Dalsgaard Sorensen, Thilo Dörk, Gerald Andriole, Joanne L. Dickinson, Cezary Cybulski, Jan Lubinski, Amanda Spurdle, Judith A. Clements, Suzanne Chambers, Joanne Aitken, R.A. Frank Gardiner, Stephen N. Thibodeau, Dan Schaid, Esther M. John, Christiane Maier, Walther Vogel, Kathleen A. Cooney, Jong Y. Park, Lisa Cannon-Albright,, Hermann Brenner, Tomonori Habuchi, Hong-Wei Zhang, Yong-Jie Lu, Radka Kaneva, Ken Muir, Sara Benlloch, Daniel A. Leongamornlert, Edward J. Saunders Malgorzata Tymrakiewicz, Nadiya Mahmud, Michelle Guy, Lynne T. O'Brien, Rosemary A. Wilkinson, Amanda L. Hall, Emma J. Sawyer, Tokhir Dadaev, Jonathan Morrison, David P. Dearnaley, Alan Horwich, Robert A. Huddart, Vincent S. Khoo, Christopher C. Parker, Nicholas Van As, Christopher J. Woodhouse, Alan Thompson, Tim Christmas, Chris Ogden, Colin S. Cooper, Aritaya Lophatonanon, Melissa C. Southey, John L. Hopper, Dallas English, Tiina Wahlfors, Teuvo LJ Tammela, Peter Klarskov, Børge G. Nordestgaard, M. Andreas Røder, Anne Tybjærg-Hansen, Stig E. Bojesen, Ruth Travis, Daniele Campa, Rudolf Kaaks, Fredrik Wiklund, Markus Aly, Sara Lindstrom, W Ryan Diver, Susan Gapstur, Mariana C Stern, Roman Corral, Jarmo Virtamo, Angela Cox, Christopher A. Haiman, Loic Le Marchand, Liesel FitzGerald, Suzanne Kolb, Erika M. Kwon, Danielle M. Karyadi, Torben Falck Orntoft, Michael Borre, Andreas Meyer, Jürgen Serth, Meredith Yeager, Sonja I. Berndt, James R Marthick, Briony Patterson, Dominika Wokolorczyk, Jyotsna Batra, Felicity Lose, Shannon K McDonnell, Amit D. Joshi, Ahva Shahabi, Antje E. Rinckleb, Ana Ray, Thomas A. Sellers, Huo-Yi Lin, Robert A Stephenson, James Farnham, Heiko Muller, Dietrich Rothenbacher, Norihiko Tsuchiya, Shintaro Narita, Guang-Wen Cao, Chavdar Slavov, Vanio Mitev, The UK Genetic Prostate Cancer Study Collaborators/British Association of Urological Surgeons' Section of Oncology, The UK ProtecT Study Collaborators, The PRACTICAL Consortium, Douglas F. Easton, Rosalind A. Eeles.
Seven novel prostate cancer susceptibility loci identified by a multi-stage genome-wide association study.
Nat Genet. 2011 Jul 10;43(8):785-791. PubMed
Lamy P, Grove J, Wiuf C.
A review of software for microarray genotyping.
Hum Genomics. 2011 May 1;5(4):304-9. PubMed
Laurila K, Oster B, Andersen CL, Lamy P, Orntoft T, Yli-Harja O, Wiuf C.
A Beta-Mixture Model for Dimensionality Reduction, Sample Classification and Analysis.
BMC Bioinformatics. 2011 May 27;12(1):215. [Epub ahead of print] PubMed
Munksgaard PP, Mansilla F, Brems Eskildsen AS, Fristrup N, Birkenkamp-Demtröder K, Ulhøi BP, Borre M, Agerbæk M, Hermann GG, Orntoft TF, Dyrskjøt L.
Low ANXA10 expression is associated with disease aggressiveness in bladder cancer.
Br J Cancer. 2011 Oct 25;105(9):1379-87. doi: 10.1038/bjc.2011.404. Epub 2011 Oct 6. PubMed
Nordentoft IK, Andersen LD, Bødker JS, Wild P, Hartmann A, Bertz S, Lehmann J, Ørntoft TF, Birkenkamp-Demtröder K.
Increased expression of Transcription Factor TFAP2 alpha correlates with chemosensitivity in advanced bladder cancer.
BMC Cancer. 2011 Apr 14;11(1):135. [Epub ahead of print] PubMed
Orntoft TF.
Personalised treatment for bladder cancer.
Lancet Oncol. 2011 Feb;12(2):111-2. Epub 2011 Jan 20. PubMed
Oster B, Thorsen K, Lamy P, Wojdacz TK, Hansen LL, Birkenkamp-Demtröder K, Sørensen KD, Laurberg S, Orntoft TF, Andersen CL.
Identification and validation of highly frequent CpG island hypermethylation in colorectal adenomas and carcinomas
Int J Cancer. 2011 Dec 15;129(12):2855-66. doi: 10.1002/ijc.25951. Epub 2011 Apr 1. PubMed
Reinert T, Modin C, Mansilla F, Lamy P, Wojdacz TK, Hansen LL, Wiuf C, Borre M, Dyrskjøt L, and Orntoft TF.
Comprehensive Genome Methylation Analysis in Bladder Cancer; Identification and Validation of Novel Methylated Genes and Application of These As Urinary Tumor Markers.
Clin Cancer Res. 2011 Sep 1;17(17):5582-92. Epub 2011 Jul 25. PubMed
Schepeler T, Holm A, Halvey P, Nordentoft I, Lamy P, Riising EM, Christensen LL, Thorsen K, Liebler DC, Helin K, Orntoft TF, Andersen CL.
Attenuation of the beta-catenin/TCF4 complex in colorectal cancer cells induces several growth-suppressive microRNAs that target cancer promoting genes.
Oncogene. 2011 Oct 3. doi: 10.1038/onc.2011.453. [Epub ahead of print] PubMed
The Schizophrenia Psychiatric Genome-Wide Association Study (GWAS) Consortium, Ripke S, Sanders AR, Kendler KS, Levinson DF, Sklar P, Holmans PA, Lin DY, Duan J, Ophoff RA, Andreassen OA, Scolnick E, Cichon S, St Clair D, Corvin A, Gurling H, Werge T, Rujescu D, Blackwood DH, Pato CN, Malhotra AK, Purcell S, Dudbridge F, Neale BM, Rossin L, Visscher PM, Posthuma D, Ruderfer DM, Fanous A, Stefansson H, Steinberg S, Mowry BJ, Golimbet V, De Hert M, Jönsson EG, Bitter I, Pietiläinen OP, Collier DA, Tosato S, Agartz I, Albus M, Alexander M, Amdur RL, Amin F, Bass N, Bergen SE, Black DW, Børglum AD, Brown MA, Bruggeman R, Buccola NG, Byerley WF, Cahn W, Cantor RM, Carr VJ, Catts SV, Choudhury K, Cloninger CR, Cormican P, Craddock N, Danoy PA, Datta S, de Haan L, Demontis D, Dikeos D, Djurovic S, Donnelly P, Donohoe G, Duong L, Dwyer S, Fink-Jensen A, Freedman R, Freimer NB, Friedl M, Georgieva L, Giegling I, Gill M, Glenthøj B, Godard S, Hamshere M, Hansen M, Hansen T, Hartmann AM, Henskens FA, Hougaard DM, Hultman CM, Ingason A, Jablensky AV, Jakobsen KD, Jay M, Jürgens G, Kahn RS, Keller MC, Kenis G, Kenny E, Kim Y, Kirov GK, Konnerth H, Konte B, Krabbendam L, Krasucki R, Lasseter VK, Laurent C, Lawrence J, Lencz T, Lerer FB, Liang KY, Lichtenstein P, Lieberman JA, Linszen DH, Lönnqvist J, Loughland CM, Maclean AW, Maher BS, Maier W, Mallet J, Malloy P, Mattheisen M, Mattingsdal M, McGhee KA, McGrath JJ, McIntosh A, McLean DE, McQuillin A, Melle I, Michie PT, Milanova V, Morris DW, Mors O, Mortensen PB, Moskvina V, Muglia P, Myin-Germeys I, Nertney DA, Nestadt G, Nielsen J, Nikolov I, Nordentoft M, Norton N, Nöthen MM, O'Dushlaine CT, Olincy A, Olsen L, O'Neill FA, Orntoft TF, Owen MJ, Pantelis C, Papadimitriou G, Pato MT, Peltonen L, Petursson H, Pickard B, Pimm J, Pulver AE, Puri V, Quested D, Quinn EM, Rasmussen HB, Réthelyi JM, Ribble R, Rietschel M, Riley BP, Ruggeri M, Schall U, Schulze TG, Schwab SG, Scott RJ, Shi J, Sigurdsson E, Silverman JM, Spencer CC, Stefansson K, Strange A, Strengman E, Stroup TS, Suvisaari J, Terenius L, Thirumalai S, Thygesen JH, Timm S, Toncheva D, van den Oord E, van Os J, van Winkel R, Veldink J, Walsh D, Wang AG, Wiersma D, Wildenauer DB, Williams HJ, Williams NM, Wormley B, Zammit S, Sullivan PF, O'Donovan MC, Daly MJ, Gejman PV.
Genome-wide association study identifies five new schizophrenia loci.
Nat Genet. 2011 Sep 18;43(10):969-76. doi: 10.1038/ng.940. PubMed
Steinberg S, de Jong S; Irish Schizophrenia Genomics Consortium, Andreassen OA, Werge T, Børglum AD, Mors O, Mortensen PB, Gustafsson O, Costas J, Pietiläinen OP, Demontis D, Papiol S, Huttenlocher J, Mattheisen M, Breuer R, Vassos E, Giegling I, Fraser G, Walker N, Tuulio-Henriksson A, Suvisaari J, Lönnqvist J, Paunio T, Agartz I, Melle I, Djurovic S, Strengman E; GROUP, Jürgens G, Glenthøj B, Terenius L, Hougaard DM, Orntoft T, Wiuf C, Didriksen M, Hollegaard MV, Nordentoft M, van Winkel R, Kenis G, Abramova L, Kaleda V, Arrojo M, Sanjuán J, Arango C, Sperling S, Rossner M, Ribolsi M, Magni V, Siracusano A, Christiansen C, Kiemeney LA, Veldink J, van den Berg L, Ingason A, Muglia P, Murray R, Nöthen MM, Sigurdsson E, Petursson H, Thorsteinsdottir U, Kong A, Rubino IA, De Hert M, Réthelyi JM, Bitter I, Jönsson EG, Golimbet V, Carracedo A, Ehrenreich H, Craddock N, Owen MJ, O'Donovan MC; Wellcome Trust Case Control Consortium, Ruggeri M, Tosato S, Peltonen L, Ophoff RA, Collier DA, St Clair D, Rietschel M, Cichon S, Stefansson H, Rujescu D, Stefansson K.
Common Variants at VRK2 and TCF4 Conferring Risk of Schizophrenia.
Hum Mol Genet. 2011 Jul 26. [Epub ahead of print] PubMed
Thorsen K, Schepeler T, Oster B, Rasmussen MH, Vang S, Wang K, Hansen KQ, Lamy P, Pedersen JS, Eller A, Mansilla F, Laurila K, Wiuf C, Laurberg S, Dyrskjot L, Orntoft TF, Andersen CL.
Tumor-specific usage of alternative transcription start sites in colorectal cancer identified by genome-wide exon array analysis.
BMC Genomics. 2011 Oct 14;12(1):505. [Epub ahead of print] PubMed
Villadsen SB, Bramsen JB, Ostenfeld MS, Wiklund ED, Fristrup N, Gao S, Hansen TB, Jensen TI, Borre M, Orntoft TF, Dyrskjøt L, Kjems J.
The miR-143/-145 cluster regulates plasminogen activator inhibitor-1 in bladder cancer.
Br J Cancer. 2012 Jan 17;106(2):366-74. doi: 10.1038/bjc.2011.520. Epub 2011 Nov 22. PubMed
Wach S, Nolte E, Szczyrba J, Stöhr R, Hartmann A, Orntoft T, Dyrskjøt L, Eltze E, Wieland W, Keck B, Ekici AB, Grässer F, Wullich B.
MiRNA profiles of prostate carcinoma detected by multi-platform miRNA screening.
Int J Cancer. 2012 Feb 1;130(3):611-21. doi: 10.1002/ijc.26064. Epub 2011 May 9. PubMed
Wiklund ED, Bramsen JB, Hulf T, Dyrskjøt L, Ramanathan R, Hansen TB, Villadsen SB, Gao S, Ostenfeld MS, Borre M, Peter ME, Orntoft TF, Kjems J, Clark SJ.
Coordinated epigenetic repression of the miR-200 family and miR-205 in invasive bladder cancer.
Int J Cancer. 2011 Mar 15;128(6):1327-34. doi: 10.1002/ijc.25461. PubMed
2010
Alhopuro P, Björklund M, Sammalkorpi H, Turunen M, Tuupanen S, Biström M, Niittymäki I, Lehtonen HJ, Kivioja T, Launonen V, Saharinen J, Nousiainen K, Hautaniemi S, Nuorva K, Mecklin JP, Järvinen H, Orntoft T, Arango D, Lehtonen R, Karhu A, Taipale J, Aaltonen LA.
Mutations in the Circadian Gene CLOCK in Colorectal Cancer.
Mol Cancer Res. 2010 Jul;8(7):952-60. Epub 2010 Jun 15. PubMed
Andersen CL, Lamy P, Thorsen K, Kjeldsen E, Wikman F, Villesen P, Oster B, Laurberg S, Orntoft TF.Frequent genomic loss at chr16p13.2 is associated with poor prognosis in colorectal cancer.
Int J Cancer. 2010 Dec 10. [Epub ahead of print] PubMed
Brems-Eskildsen AS, Zieger K, Toldbod H, Holcomb C, Higuchi R, Mansilla F, Munksgaard PP, Borre M, Orntoft TF, Dyrskjot L.
Prediction and diagnosis of bladder cancer recurrence based on urinary content of hTERT, SENP1, PPP1CA, and MCM5 transcripts.
BMC Cancer. 2010 Nov 24;10(1):646. PubMed
Hansen RL, Heeboll S, Ottosen PD, Dyrskjøt L, Borre M.
Smarcc1 expression: a significant predictor of disease-specific survival in patients with clinically localized prostate cancer treated with no intention to cure.
Scand J Urol Nephrol. 2011 Mar;45(2):91-6. Epub 2010 Nov 18. PubMed
Lamy P, Wiuf C, Orntoft TF, Andersen CL.
Rseg - an R package to optimize segmentation of SNP array data.
Bioinformatics. 2011 Feb 1;27(3):419-20. Epub 2010 Dec 5. PubMed
Marteau JB, Rigaud O, Brugat T, Gault N, Vallat L, Kruhoffer M, Orntoft TF, Nguyen-Khac F, Chevillard S, Merle-Beral H, Delic J.
Concomitant heterochromatinisation and down-regulation of gene expression unveils epigenetic silencing of RELB in an aggressive subset of chronic lymphocytic leukemia in males.
BMC Med Genomics. 2010 Nov 10;3(1):53. [Epub ahead of print] PubMed
Modin C, Bjerregaard B, Ørntoft T, Høgdall E; Faglig Følgegruppe for Dansk CancerBiobank.
[Establishing the Danish CancerBiobank]
Ugeskr Laeger. 2010 May 10;172(19):1446-50. Danish. PubMed
Moore F, Naamane N, Colli ML, Bouckenooghe T, Ortis F, Gurzov EN, Igoillo-Esteve M, Mathieu C, Bontempi G, Thykjaer T, Orntoft TF, Eizirik DL
STAT1 is a master regulator of pancreatic beta cells apoptosis and islet inflammation.
J Biol Chem. 2011 Jan 14;286(2):929-41. Epub 2010 Oct 27. PubMed
Niittymäki I, Gylfe A, Laine L, Laakso M, Lehtonen HJ, Kondelin J, Tolvanen J, Nousiainen K, Pouwels J, Järvinen H, Nuorva K, Mecklin JP, Mäkinen M, Ristimäki A, Orntoft TF, Hautaniemi S, Karhu A, Kallio MJ, Aaltonen LA.
High frequency of TTK mutations in microsatellite-unstable colorectal cancer and evaluation of their effect on spindle-assembly checkpoint.
Carcinogenesis. 2011 Mar;32(3):305-11. Epub 2010 Dec 16. PubMed
Out AA, Tops CM, Nielsen M, Weiss MM, van Minderhout IJ, Fokkema IF, Buisine MP, Claes K, Colas C, Fodde R, Fostira F, Franken PF, Gaustadnes M, Heinimann K, Hodgson SV, Hogervorst FB, Holinski-Feder E, Lagerstedt-Robinson K, Olschwang S, van den Ouweland AM, Redeker EJ, Scott RJ, Vankeirsbilck B, Grønlund RV, Wijnen JT, Wikman FP, Aretz S, Sampson JR, Devilee P, den Dunnen JT, Hes FJ.
Leiden Open Variation Database of the MUTYH gene.
Hum Mutat. 2010 Nov;31(11):1205-15. PubMed
Skovby F, Gaustadnes M, Mudd SH.
A revisit to the natural history of homocystinuria due to cystathionine beta-synthase deficiency
Mol Genet Metab. 2010 Jan;99(1):1-3. PubMed
Sørensen KD, Orntoft TF.
Discovery of prostate cancer biomarkers by microarray gene expression profiling.
Expert Rev Mol Diagn. 2010 Jan;10(1):49-64. PubMed
Thorsen K, Mansilla F, Schepeler T, Oster B, Rasmussen MH, Dyrskjot L, Karni R, Akerman M, Krainer AR, Laurberg S, Andersen CL, Orntoft TF
Alternative splicing of SLC39A14 in colorectal cancer is regulated by the Wnt pathway.
Mol Cell Proteomics. 2011 Jan;10(1):M110.002998. Epub 2010 Oct 11. PubMed
Vestergaard EM, Nexø E, Tørring N, Borre M, Orntoft TF, Sørensen KD.
Promoter hypomethylation and upregulation of trefoil factors in prostate cancer.
Int J Cancer. Int J Cancer. 2010 Oct 15;127(8):1857-65. PubMed
2005-2009
2009
Andersen CL, Christensen LL, Thorsen K, Schepeler T, Sorensen FB, Verspaget HW, Simon R, Kruhoffer M, Aaltonen LA, Laurberg S, Orntoft TF.
Dysregulation of the transcription factors SOX4, CBFB and SMARCC1 correlates with outcome of colorectal cancer.
Br J Cancer. 2009 Feb 10;100(3):511-23. Epub 2009 Jan 20. PubMed
Berchtold LA, Larsen CM, Vaag A, Faulenbach M, Workman CT, Kruhøffer M, Donath M, Mandrup-Poulsen T.
IL-1 receptor antagonism and muscle gene expression in patients with type 2 diabetes.
Eur Cytokine Netw. 2009 Jun 1;20(2):81-87. PubMed
Christensen LL, Kariola R, Korhonen MK, Wikman FP, Sunde L, Gerdes AM, Okkels H, Brandt CA, Bernstein I, Hansen TV, Hagemann-Madsen R, Andersen CL, Nyström M, Ørntoft TF.
Functional characterization of rare missense mutations in MLH1 and MSH2 identified in Danish colorectal cancer patients.
Fam Cancer. 2009;8(4):489-500. Epub 2009 Aug 21. PubMed
Dyrskjøt L, Ostenfeld MS, Bramsen JB, Silahtaroglu AN, Lamy P, Ramanathan R, Fristrup N, Jensen JL, Andersen CL, Zieger K, Kauppinen S, Ulhøi BP, Kjems J, Borre M, Ørntoft TF.
Genomic Profiling of MicroRNAs in Bladder Cancer; miR-129 Is Associated with Poor Outcome and Promotes Cell Death In vitro.
Cancer Research. 2009 Jun 1;69(11):4851-60. PubMed
Egerod FL, Bartels A, Fristrup N, Borre M, Orntoft TF, Oleksiewicz MB, Brunner N, Dyrskjot L.
High frequency of tumor cells with nuclear Egr-1 protein expression in human bladder cancer is associated with disease progression.
BMC Cancer. 2009 Oct 30;9(1):385. [Epub ahead of print] PubMed
Heebøll S, Borre M, Ottosen PD, Dyrskjøt L, Orntoft TF, Tørring N.
Snail1 is over-expressed in prostate cancer.
APMIS. 2009 Mar;117(3):196-204. PubMed
Hollegaard MV, Grauholm J, Borglum A, Nyegaard M, Norgaard-Pedersen B, Orntoft T, Mortensen PB, Wiuf C, Mors O, Didriksen M, Thorsen P, Hougaard DM.
Genome-wide scans using archived neonatal dried blood spot samples.
BMC Genomics. 2009 Jul 4;10(1):297. [Epub ahead of print] PubMed
Jensen SA, Vainer B, Kruhoffer M, Sorensen JB.
Microsatellite instability in colorectal cancer and association with thymidylate synthase and dihydropyrimidine dehydrogenase expression.
BMC Cancer. 2009 Jan 20;9:25. PubMed
Jorissen RN, Gibbs P, Christie M, Prakash S, Lipton L, Desai J, Kerr D, Aaltonen LA, Arango D, Kruhøffer M, Orntoft TF, Andersen CL, Gruidl M, Kamath VP, Eschrich S, Yeatman TJ, Sieber OM.
Metastasis-Associated Gene Expression Changes Predict Poor Outcomes in Patients with Dukes Stage B and C Colorectal Cancer.
Clin Cancer Res. 2009 Dec 15;15(24):7642-7651. Epub. PubMed
Mansilla F, Lamy P, Ørntoft TF, and Birkenkamp-Demtröder K.
Genes Involved in Human Ribosome Biogenesis are Transcriptionally Upregulated in Colorectal Cancer.
Scholarly Research Exchange, vol. 2009, Article ID 657042, 2009. doi:10.3814/2009/657042
Mauvezin C, Orpinell M, Francis VA, Mansilla F, Duran J, Ribas V, Palacín M, Boya P, Teleman AA and Zorzano A.
The nuclear cofactor DOR regulates autophagy in mammalian and Drosophila cells.
EMBO Rep. 2010 Jan;11(1):37-44. Epub 2009 Dec 4. PubMed
Ortis F, Naamane N, Flamez D, Ladrière L, Moore F, Cunha DA, Colli ML, Thykjaer T, Thorsen K, Orntoft TF, Eizirik DL.
The cytokines IL-1{beta} and TNF-{alpha} regulate different transcriptional and alternative splicing networks in primary beta cells.
Diabetes. 2010 Feb;59(2):358-74. Epub 2009 Nov 23. PubMed
Ostenfeld MS, Bramsen JB, Lamy P, Villadsen SB, Fristrup N, Sørensen KD, Ulhøi B, Borre M, Kjems J, Dyrskjøt L, Orntoft TF.
miR-145 induces caspase-dependent and -independent cell death in urothelial cancer cell lines with targeting of an expression signature present in Ta bladder tumors.
Oncogene. 2010 Feb 18;29(7):1073-84. Epub 2009 Nov 16. PubMed
Sørensen KD, Wild PJ, Mortezavi A, Adolf K, Tørring N, Heebøll S, Ulhøi BP, Ottosen P, Sulser T,
Hermanns T, Moch H, Borre M, Ørntoft TF and Dyrskjøt L.
Genetic and Epigenetic SLC18A2 Silencing in Prostate Cancer is an Independent Adverse Predictor of Biochemical Recurrence after Radical Prostatectomy.
Clin Cancer Res. 2009 Feb 15;15(4):1400-10. PubMed
Zieger K, Marcussen N, Borre M, Ørntoft TF, Dyrskjøt L.
Consistent genomic alterations in carcinoma in situ of the urinary bladder confirm the presence of two major pathways in bladder cancer development.
Int J Cancer. 2009 Nov 1;125(9):2095-103. PubMed
Zieger K, Wiuf C, Jensen KM, Orntoft TF, Dyrskjot L.
Chromosomal imbalance in the progression of high-risk non-muscle invasive bladder cancer.
BMC Cancer. 2009 May 16;9(1):149. PubMed
2008
According to JCR Science Edition 2008, the total impact factor of these 28 publications is 98 (3 journals not present), with 17 publications with an impact factor above 2.5.
Alhopuro P, Phichith D, Tuupanen S, Sammalkorpi H, Nybondas M, Saharinen J, Robinson JP, Yang Z, Chen LQ, Orntoft T, Mecklin JP, Järvinen H, Eng C, Moeslein G, Shibata D, Houlston RS, Lucassen A, Tomlinson IP, Launonen V, Ristimäki A, Arango D, Karhu A, Sweeney HL, Aaltonen LA.
Unregulated smooth-muscle myosin in human intestinal neoplasia.
Proc Natl Acad Sci U S A. 2008 Apr 8;105(14):5513-8. Epub 2008 Apr 7. PubMed
Braun CJ, Zhang X, Savelyeva I, Wolff S, Moll UM, Schepeler T, Ørntoft TF, Andersen CL, Dobbelstein M.
p53-Responsive micrornas 192 and 215 are capable of inducing cell cycle arrest.
Cancer Res. 2008 Dec 15;68(24):10094-104. PubMed
Bross P, Naundrup S, Hansen J, Nielsen MN, Christensen JH, Kruhøffer M, Palmfeldt J, Corydon TJ, Gregersen N, Ang D, Georgopoulos C, Nielsen KL.
The HSP60-(P.val98ile) mutation associated with hereditary spastic paraplegia SPG13 compromises chaperonin function both in vitro and in vivo.
J Biol Chem. 2008 Jun 6;283(23):15694-700. Epub 2008 Apr 8. PubMed
Christensen LL, Madsen BE, Wikman FP, Wiuf C, Koed K, Tjoennland A, Olsen A, Syvanen AC, Andersen CL, Orntoft TF.
The association between genetic variants in hMLH1 and hMSH2 and the development of sporadic colorectal cancer in the Danish population.
BMC Med Genet. 2008 Jun 11;9(1):52 [Epub ahead of print] PubMed
Ehlers N, Hjortdal J, Nielsen K, Thiel HJ, Ørntoft T.
Phenotypic variability in Meesmann's dystrophy: clinical review of the literature and presentation of a family genetically identical to the original family.
Acta Ophthalmol Scand. 2008 Feb;86(1):40-4. Epub 2007 Nov 6. Review. PubMed
Heebøll S, Borre M, Ottosen PD, Andersen CL, Mansilla F, Dyrskjøt L, Orntoft TF, Tørring N.
SMARCC1 expression is upregulated in prostate cancer and positively correlated with tumour recurrence and dedifferentiation.
Histol Histopathol. 2008 Sep;23(9):1069-76. PubMed
Herbsleb M, Birkenkamp-Demtroder K, Thykjaer T, Wiuf C, Hein AM, Orntoft TF, Dyrskjøt L.
Increased cell motility and invasion upon knockdown of lipolysis stimulated lipoprotein receptor (LSR) in SW780 bladder cancer cells.
BMC Med Genomics. 2008 Jul 22;1:31. PubMed
Herbsleb M, Christensen OF, Thykjaer T, Wiuf C, Borre M, Orntoft TF, Dyrskjot L.
Bioinformatic identification of FGF, p38-MAPK, and calcium signalling pathways associated with carcinoma in situ in the urinary bladder.
BMC Cancer. 2008 Jan 31;8(1):37 [Epub ahead of print] PubMed
Jorissen RN, Lipton L, Gibbs P, Chapman M, Desai J, Jones IT, Yeatman TJ, East P, Tomlinson IP, Verspaget HW, Aaltonen LA, Kruhøffer M, Orntoft TF, Andersen CL, Sieber OM.
Links DNA copy-number alterations underlie gene expression differences between microsatellite stable and unstable colorectal cancers.
Clin Cancer Res. 2008 Dec 15;14(24):8061-9. PubMed
Kirkegaard I, Petersen OB, Uldbjerg N, Tørring N.
Improved performance of first-trimester combined screening for trisomy 21 with the double test taken before a gestational age of 10 weeks.
Prenat Diagn. 2008 Sep;28(9):839-44. PubMed
Mansilla F, da Costa KA, Wang S, Kruhøffer M, Lewin TM, Orntoft TF, Coleman RA, Birkenkamp-Demtröder K.
Lysophosphatidylcholine acyltransferase 1 (LPCAT1) overexpression in human colorectal cancer.
J Mol Med. 2009 Jan;87(1):85-97. Epub 2008 Oct 31. PubMed
Mansilla F, Dominguez CA, Yeadon JE, Corydon TJ, Burden SJ, Knudsen CR.
Translation elongation factor eEF1A binds to a novel myosin binding protein-C-like protein.
J Cell Biochem. 2008 Oct 15;105(3):847-5. PubMed
Nilbert M, Wikman FP, Hansen TV, Krarup HB, Orntoft TF, Nielsen FC, Sunde L, Gerdes AM, Cruger D, Timshel S, Bisgaard ML, Bernstein I, Okkels H.
Major contribution from recurrent alterations and MSH6 mutations in the Danish Lynch syndrome population.
Fam Cancer. 2009;8(1):75-83. Epub 2008 Jun 20. PubMed
Nielsen FC, Ørntoft TF; Dansk Selskab for Klinisk Biokemi.
[Genomic microarray technology. The Danish Society of Clinical Biochemistry]
Ugeskr Laeger. 2008 Mar 17;170(12):1037. Danish. No abstract available. PubMed
Nielsen K, Orntoft T, Hjortdal J, Rasmussen T, Ehlers N.
A novel mutation as the basis for asymptomatic meesmann dystrophy in a Danish family.
Cornea. 2008 Jan;27(1):100-2. PubMed
Offenberg H, Brünner N, Mansilla F, Ørntoft TF and Birkenkamp-Demtroder K.
TIMP-1 expression in human colorectal cancer is associated with TGF-B1, LOXL2, INHBA1, TNF-AIP6 and TIMP-2 transcript profiles.
Mol Oncol. 2008 Oct;2(3):233-40. Epub 2008 Jun 18. PubMed
Reusens B, Sparre T, Kalbe L, Bouckenooghe T, Theys N, Kruhøffer M, Orntoft TF, Nerup J, Remacle C.
The intrauterine metabolic environment modulates the gene expression pattern in fetal rat islets: prevention by maternal taurine supplementation.
Diabetologia. 2008 May;51(5):836-45. Epub 2008 Mar 3. PubMed
Sammalkorpi H, Alhopuro P, Niittymäki I, Orntoft TF, Hokland P, Karhu A, Aaltonen LA.
Mutation analysis of MYH11 in acute myeloid leukemia.
Leuk Lymphoma. 2008 Sep;49(9):1829-31. No abstract available. PubMed
Schepeler T, Reinert JT, Ostenfeld MS, Christensen LL, Silahtaroglu AN, Dyrskjøt L, Wiuf C, Sørensen FJ, Kruhøffer M, Laurberg S, Kauppinen S, Ørntoft TF, Andersen CL.
Diagnostic and prognostic microRNAs in stage II colon cancer.
Cancer Res. 2008 Aug 1;68(15):6416-24. PubMed
Spencer K, Cowans NJ, Uldbjerg N, Tørring N.
First-trimester ADAM12s as early markers of trisomy 21: a promise still unfulfilled?
Prenat Diagn. 2008 Apr;28(4):338-42. PubMed
Spencer K, Cowans NJ, Uldbjerg N, Vereecken A, Tørring N. First trimester intact hCG as an early marker of trisomy 21: a promise unrecognised? Prenat Diagn. 2008 Nov 12; [Epub ahead of print] PubMed
Sørensen KD, Borre M, Ørntoft TF, Dyrskjøt L, Tørring N.
Chromosomal deletion, promoter hypermethylation and downregulation of FYN in prostate cancer.
Int J Cancer. 2008 Feb 1;122(3):509-19. PubMed
Thorsen K, Sørensen KD, Brems-Eskildsen AS, Modin C, Gaustadnes M, Hein AM, Kruhøffer M, Laurberg S, Borre M, Wang K, Brunak S, Krainer AR, Tørring N, Dyrskjøt L, Andersen CL, Orntoft TF.
Alternative splicing in colon, bladder, and prostate cancer identified by exon-array analysis.
Mol Cell Proteomics. 2008 Jul;7(7):1214-24. Epub 2008 Mar 18. PubMed
Tørring N, Jølving LR, Petersen OB, Holmskov A, Hertz JM, Uldbjerg N.
[Prenatal diagnostics in Arhus and Viborg Counties after implementation of first trimester risk assessment] Ugeskr Laeger. 2008 Jan 7;170(1):50-4. Danish. PubMed
Obro NF, Lademann U, Birkenkamp-Demtroder K, Holten-Andersen L, Brünner N, Offenberg H.
A TIMP-1 splice variant transcript: Possible role in regulation of TIMP-1 expression.
Cancer Lett. 2008 Jan 2 [Epub ahead of print] PubMed
Ørntoft TF, Dyrskjøt L. Gene signatures for risk-adapted treatment of bladder cancer. Scand J Urol Nephrol Suppl. 2008 Sep;(218):166-74. PubMed
Ortis F, Pirot P, Naamane N, Kreins AY, Rasschaert J, Moore F, Théâtre E, Verhaeghe C, Magnusson NE, Chariot A, Orntoft TF, Eizirik DL.
Induction of nuclear factor-kappaB and its downstream genes by TNF-alpha and IL-1beta has a pro-apoptotic role in pancreatic beta cells.
Diabetologia. 2008 May 8; [Epub ahead of print] PubMed
Wang Y, Kowalski J, Tsai HL, Marik R, Prasad N, Somervell H, Lo PK, Sangenario LE, Dyrskjot L, Orntoft TF, Westra WH, Meeker AK, Eshleman JR, Umbricht CB, Zeiger MA.
Differentiating Alternative Splice Variant Patterns of Human Telomerase Reverse Transcriptase in Thyroid Neoplasms.
Thyroid. 2008 Sep 24; [Epub ahead of print] PubMed
2007
According to JCR Science Edition 2007, the total impact factor of these 23 publications is 96 (2 journals not present), with 19 publications with an impact factor above 2.5.
Adolf K, Wagner L, Bergh A, Stattin P, Ottosen P, Borre M, Birkenkamp-Demtröder K, Orntoft TF, Torring N.
Secretagogin is a new neuroendocrine marker in the human prostate.
The Prostate. 2007 Apr 1;67(5):472-84. Epub 2007 Feb 6. PubMed
Als AB, Dyrskjøt L, von der Maase H, Koed K, Mansilla F, Toldbod HE, Jensen JL, Ulhøi BP, Sengeløv L, Jensen KM, Ørntoft TF.
Emmprin and Survivin Predict Response and Survival following Cisplatin-Containing Chemotherapy in Patients with Advanced Bladder Cancer.
Clin Cancer Res. 2007 Aug 1;13(15):4407-14 PubMed
Andersen CL, Schepeler T, Thorsen K, Birkenkamp-Demtröder K, Mansilla F, Aaltonen LA, Laurberg S, Ørntoft TF.
Clusterin expression in normal mucosa and colorectal cancer.
Mol Cell Proteomics. 2007 Jun;6(6):1039-48. Epub 2007 Feb 23. PubMed
Bergholdt R, Karlsen AE, Hagedorn PH, Aalund M, Nielsen JH, Kruhoffer M, Orntoft T, Wang H, Wollheim CB, Nerup J, Pociot F.
Transcriptional profiling of type 1 diabetes genes on chromosome 21 in a rat beta-cell line and human pancreatic islets.
Genes Immun. 2007 Apr;8(3):232-8. Epub 2007 Mar 1. PubMed
Birkenkamp-Demtroder, K., Mansilla, F., Sørensen F.B., Kruhoeffer, M., Christensen, L.L., Aaltonen, L.A., Verspaget, H.W. and Ørntoft T.F.
Phosphoprotein Keratin 23 accumulates in MSS but not MSI colon cancers in vivo and impacts viability and proliferation in vitro.
Mol Oncol. 2007 Sep;1(2):181-95. Epub 2007 Jun 3. PubMed
Daugaard M, Kirkegaard-Sorensen T, Ostenfeld MS, Aaboe M, Hoyer-Hansen M, Orntoft TF, Rohde M, Jaattela M.
Lens Epithelium-Derived Growth Factor Is an Hsp70-2 Regulated Guardian of Lysosomal Stability in Human Cancer.
Cancer Res. 2007 Mar 15;67(6):2559-2567. PubMed
De Martino I, Visone R, Palmieri D, Cappabianca P, Chieffi P, Forzati F, Barbieri A, Kruhoffer M, Lombardi G, Fusco A, Fedele M.
The Mia/Cd-rap gene expression is downregulated by the high-mobility group A proteins in mouse pituitary adenomas.
Endocr Relat Cancer. 2007 Sep;14(3):875-886. PubMed
Dyrskjot L, Zieger K, Orntoft TF.
Recent advances in high-throughput molecular marker identification for superficial and invasive bladder cancers.
Front Biosci. 2007 Jan 1;12:2063-73. Review. PubMed
Dyrskjot L, Zieger K, Real FX, Malats N, Carrato A, Hurst C, Kotwal S, Knowles M, Malmstrom PU, de la Torre M, Wester K, Allory Y, Vordos D, Caillault A, Radvanyi F, Hein AM, Jensen JL, Jensen KM, Marcussen N, Orntoft TF.
Gene expression signatures predict outcome in non-muscle-invasive bladder carcinoma: a multicenter validation study.
Clin Cancer Res. 2007 Jun 15;13(12):3545-51. PubMed
Ehlers N, Hjortdal J, Nielsen K, Thiel HJ, Orntoft T.
Phenotypic variability in Meesmann's dystrophy: clinical review of the literature and presentation of a family genetically identical to the original family.
Acta Ophthalmol Scand. 2007 Nov 6. PubMed
Kruhoffer M, Dyrskjot L, Voss T, Lindberg RL, Wyrich R, Thykjaer T, Orntoft TF.
Isolation of Microarray-Grade Total RNA, MicroRNA, and DNA from a Single PAXgene Blood RNA Tube.
J Mol Diagn. 2007 [Epub ahead of print] PubMed
Lamy P, Andersen CL, Dyrskjot L, Torring N, Wiuf C.
A Hidden Markov Model to estimate population mixture and allelic copy-numbers in cancers using Affymetrix SNP arrays.
BMC Bioinformatics. 2007 Nov 9;8(1):434. PubMed
Larsen PF, Nielsen EE, Williams TD, Hemmer-Hansen J, Chipman JK, Kruhoffer M, Gronkjaer P, George SG, Dyrskjot L, Loeschcke V.
Adaptive differences in gene expression in European flounder (Platichthys flesus).
Mol Ecol. 2007 Oct 8; [Epub ahead of print] PubMed
Mansilla, F., Wang, S., da Costa, K.A., Kruhøffer, M., Lewin, T.M., Ørntoft,T.F., Coleman, R.A. and Birkenkamp-Demtroder, K. (2007) From microarray analysis to protein function: Overexpression of LPCAT1 in colorectal cancer.
Journal of Biotechnology, Volume 131, Issue 2, Supplement 1
Mansilla F, Birkenkamp-Demtroder K, Kruhoffer M, Sorensen FB, Andersen CL, Laiho P, Aaltonen LA, Verspaget HW, Orntoft TF. Differential expression of DHHC9 in microsatellite stable and instable human colorectal cancer subgroups. Br J Cancer. 2007 96(12):1896-1903. Epub 2007 May 22. PubMed
Niemelä AM, Hynninen P, Mecklin JP, Kuopio T, Kokko A, Aaltonen L, Parkkila AK, Pastorekova S, Pastorek J, Waheed A, Sly WS, Orntoft TF, Kruhøffer M, Haapasalo H, Parkkila S, Kivelä AJ.
Carbonic anhydrase IX is highly expressed in hereditary nonpolyposis colorectal cancer.
Cancer Epidemiol Biomarkers Prev. 2007 Sep;16(9):1760-6. PubMed
Pirot P, Naamane N, Libert F, Magnusson NE, Orntoft TF, Cardozo AK, Eizirik DL. Global profiling of genes modified by endoplasmic reticulum stress in pancreatic beta cells reveals the early degradation of insulin mRNAs. Diabetologia. 2007 May;50(5):1006-14. Epub 2007 Mar 1. PubMed
Raitila A, Georgitsi M, Karhu A, Tuppurainen K, Makinen MJ, Birkenkamp-Demtroder K, Salmenkivi K, Orntoft TF, Arola J, Launonen V, Vahteristo P, Aaltonen LA. No evidence of somatic aryl hydrocarbon receptor interacting protein mutations in sporadic endocrine neoplasia.
Endocr Relat Cancer. 2007 Sep;14(3):901-6. PubMed
Salvig JD, Winding TN, Henriksen TB, Torring N, Pedersen OB, Uldbjerg N.
PAPP-A and fetal growth from week 12 to week 20.
Ultrasound Obstet Gynecol. 2007 Sep 21;30(4):460 PubMed
Schepeler T, Mansilla F, Christensen LL, Orntoft TF, Andersen CL.
Clusterin expression can be modulated by changes in TCF1-mediated Wnt signaling.
J Mol Signal. 2007 Jul 16;2:6. PubMed
Sorensen KD, Borre M, Orntoft TF, Dyrskjot L, Torring N.
Chromosomal deletion, promoter hypermethylation and downregulation of FYN in prostate cancer. Int J Cancer. 2007 Oct 17; [Epub ahead of print] PubMed
Torring N, Borre M, Sorensen KD, Andersen CL, Wiuf C, Orntoft TF.
Genome-wide analysis of allelic imbalance in prostate cancer using the Affymetrix 50K SNP mapping array. Br J Cancer. 2007 Feb 12;96(3):499-506. Epub 2007 Jan 23. PubMed
Visconti R, Federico A, Coppola V, Pentimalli F, Berlingieri MT, Pallante P, Kruhoffer M, Orntoft TF, Fusco A.
Transcriptional profile of Ki-Ras-induced transformation of thyroid cells.
Cancer Invest. 2007 Jun;25(4):256-66. PubMed
2006
According to JCR Science Edition 2005, the total impact factor of these 21 publications is 140, with 17 publications with an impact factor above 2.5.
Aaboe M, Birkenkamp-Demtroder K, Wiuf C, Sørensen FB, Thykjaer T, Sauter G, Møller-Ernst Jensen K, Dyrskjøt L, Ørntoft TF. SOX4 expression in bladder carcinoma: clinical aspects and in vitro functional characterization. Cancer Research. 2006. Apr 1;66(7):3434-42. PubMed Suppl Data
Andersen CL, Wiuf C, Kruhoffer M, Korsgaard M, Laurberg, S and Orntoft TF. Frequent occurrence of uniparental disomy in colorectal cancer. Carcinogenesis. 2007 Jan;28(1):38-48. Epub 2006 Jun 13. PubMed
Andersen JB, Aaboe M, Borden EC, Goloubeva OG, Hassel BA, Ørntoft TF. Stage-associated overexpression of the ubiquitin-like protein, ISG15, in bladder cancer. Br J Cancer. 2006 May 22;94(10):1465-71. PubMed
Bartkova J, Rezaei N, Liontos M, Karakaidos P, Kletsas D, Issaeva N, Vassiliou LV, Kolettas E, Niforou K, Zoumpourlis VC, Takaoka M, Nakagawa H, Tort F, Fugger K, Johansson F, Sehested M, Andersen CL, Dyrskjot L, Orntoft T, Lukas J, Kittas C, Helleday T, Halazonetis TD, Bartek J, Gorgoulis VG. Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints. Nature. 2006 Nov 30;444(7119):633-7. PubMed
Colombo M, Kruhoeffer M, Gregersen S, Agger A, Jeppesen P, Oerntoft T, Hermansen K. Energy restriction prevents the development of type 2 diabetes in Zucker diabetic fatty rats: coordinated patterns of gene expression for energy metabolism in insulin-sensitive tissues and pancreatic islets determined by oligonucleotide microarray analysis. Metabolism. 2006 Jan;55(1):43-52. PubMed Suppl Data
Dahl C, Saito H, Kruhoffer M, Schiotz PO . Identification of tryptase- and chymase-related gene clusters in human mast cells using microarrays. Allergy. 2006 Mar;61(3):276-80. PubMed
Ebbesen LS, Olesen SH, Kruhoffer M, Ingerslev J, Orntoft TF. Folate deficiency induced hyperhomocysteinemia changes the expression of thrombosis-related genes. Blood Coagul Fibrinolysis. 2006 Jun;17(4):293-301. PubMed
Frohlich C, Albrechtsen R, Dyrskjot L, Rudkjaer L, Orntoft TF, Wewer UM. Molecular Profiling of ADAM12 in Human Bladder Cancer. Clin Cancer Res. 2006 Dec 15;12(24):7359-7368. PubMed
Gaustadnes M, Orntoft TF, Jensen JL, Torring N. Validation of the use of DNA pools and primer extension in association studies of sporadic colorectal cancer for selection of candidate SNPs. Hum Mutat. 2006 Feb;27(2):187-94. PubMed
Holten-Andersen MN, Brunner N, Nielsen HJ, Christensen IJ, Sorensen NM, Rasmussen AS, Primdahl H, Orntoft T. Levels of tissue inhibitor of metalloproteinases 1 in plasma and urine from patients with bladder cancer. Int J Biol Markers. 2006 Jan-Mar;21(1):6-11. PubMed
Kristensen TN , Sorensen P, Pedersen KS , Kruhoffer M, Loeschcke V. Inbreeding by environment interactions affect gene expression in Drosophila melanogaster. Genetics. 2006 Jul;173(3):1329-36. Epub 2006 Apr 19. PubMed
Lamy P, Andersen CL, Dyrskjot L, Torring N, Orntoft T, Wiuf C. Are microRNAs located in genomic regions associated with cancer? Br J Cancer. 2006 Nov 20;95(10):1415-8. Epub 2006 Sep 26. PubMed
Marcheco-Teruel B, Flint TJ, Wikman FP, Torralbas M, Gonzalez L, Blanco L, Tan Q, Ewald H, Orntoft T, Kruse TA, Borglum AD, Mors O. A genome-wide linkage search for bipolar disorder susceptibility loci in a large and complex pedigree from the eastern part of Cuba . Am J Med Genet B Neuropsychiatr Genet. 2006 Dec 5;141(8):833-43. PubMed
Memon AA, Sorensen BS, Meldgaard P, Fokdal L, Thykjaer T, Nexo E. The relation between survival and expression of HER1 and HER2 depends on the expression of HER3 and HER4: a study in bladder cancer patients. Br J Cancer. 2006 Jun 5;94(11):1703-9. PubMed
Nielsen K, Vorum H, Fagerholm P, Birkenkamp-Demtroder K, Honore B, Ehlers N, Orntoft TF. Proteome Profiling of Corneal Epithelium and Identification of Marker Proteins for Keratoconus, a pilot study. Exp Eye Res. 2006 Feb;82(2):201-9. Epub 2005 Aug 3. PubMed
Nielsen MM, Sorensen JG, Kruhoffer M, Justesen J, Loeschcke V. Phototransduction genes are up-regulated in a global gene expression study of Drosophila melanogaster selected for heat resistance.
Cell Stress Chaperones. 2006 Winter;11(4):325-33. PubMed
Orntoft TF, Zieger K, Dyrskjot L. Recent developments in molecular profiling of bladder cancer. Curr Opin Urol. 2006 Sep;16(5):377-81. Review. PubMed
Ropero S, Fraga MF, Ballestar E, Hamelin R, Yamamoto H, Boix-Chornet M, Caballero R, Alaminos M, Setien F, Paz MF, Herranz M, Palacios J, Arango D, Orntoft TF, Aaltonen LA, Schwartz S , Esteller M. A truncating mutation of HDAC2 in human cancers confers resistance to histone deacetylase inhibition. Nat Genet. 2006 May;38(5):566-9. Epub 2006 Apr 16. PubMed
Tort F, Bartkova J, Sehested M, Orntoft T, Lukas J, Bartek J. Retinoblastoma pathway defects show differential ability to activate the constitutive DNA damage response in human tumorigenesis.
Cancer Res. 2006 Nov 1;66(21):10258-63. PubMed
Vanharanta S, Pollard PJ, Lehtonen HJ, Laiho P, Sjoberg J, Leminen A, Aittomaki K, Arola J, Kruhoffer M, Orntoft TF, Tomlinson IP, Kiuru M, Arango D, Aaltonen LA: Distinct expression profile in fumarate-hydratase-deficient uterine fibroids. Hum Mol Genet. 2006 Jan 1;15(1):97-103. Epub 2005 Nov 30. PubMed
Vestergaard EM, Borre M, Poulsen SS, Nexo E, Torring N. Plasma levels of trefoil factors are increased in patients with advanced prostate cancer. Clinical Cancer Research. 2006 Feb 1;12( 3 Pt 1):807-12. PubMed
Ylisaukko-Oja SK, Cybulski C, Lehtonen R, Kiuru M, Matyjasik J, Szymanska A, Szymanska-Pasternak J, Dyrskjot L, Butzow R, Orntoft TF, Launonen V, Lubinski J, Aaltonen LA.
Germline fumarate hydratase mutations in patients with ovarian mucinous cystadenoma.
Eur J Hum Genet. 2006 Jul;14(7):880-3. Epub 2006 Apr 26. PubMed
2005
According to JCR Science Edition 2005, the total impact factor of these 26 publications is 156, with 20 publications with an impact factor above 2.5.
Aaboe M, Marcussen N, Jensen KM, Thykjaer T, Dyrskjot L, Orntoft TF. Gene expression profiling of noninvasive primary urothelial tumours using microarrays. Br J Cancer. 2005. Nov 14;93(10):1182-90. PubMed Suppl Data
Andersen C.L., Jacobsen E., Gruszka A., Matutes E., Catovsky D., Koch J. : Recurrent genomic imbalances in B-cell splenic marginal zone lymphoma revealed by comparative genomic hybridization. Cancer genetics and Cytogenetics. 2005; 156(2):122-128. PubMed
Bartkova,J., Horejsi,Z., Koed,K., Kramer,A., Tort,F., Zieger,K., Guldberg,P., Sehested,M., Nesland,J.M., Lukas,C., Orntoft,T., Lukas,J., Bartek,J. DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis. Nature. 434(7035): 864-870. 2005. PubMed
Birkenkamp-Demtröder, K., Olesen, S.H., Sørensen,F.B., Laurberg, S., Laiho, P., Aaltonen, L.A., and Ørntoft, T.F. Differential gene expression in colon cancer of the caecum versus the sigmoid and rectosigmoid. Gut. 2005. Mar;54(3):374-84 PubMed
Birkenkamp-Demtröder K, Wagner L, Sørensen FB, Astrup LB, Gartner W, Scherübl H, Heine B, Christiansen P, Ørntoft TF. Secretagogin is a novel marker for neuroendocrine differentiation. Neuroendocrinology. 2005;82(2):121-38. Epub 2006 Jan 30 PubMed
Colombo M, Gregersen S, Kruhoeffer M, Agger A, Xiao J, Jeppesen PB, Orntoft T, Ploug T, Galbo H, Hermansen K. Prevention of hyperglycemia in Zucker diabetic fatty rats by exercise training: effects on gene expression in insulin-sensitive tissues determined by high-density oligonucleotide microarray analysis, Metabolism, 54 (12): 1571-81, 2005. PubMed Suppl Data
Dyrskjøt L, Zieger K, Kruhøffer M, Thykjaer T, Jensen JL, Primdahl H, Aziz N, Marcussen N, Møller K and Ørntoft TF. A molecular signature in superficial bladder carcinoma predicts clinical outcome. Clinical Cancer Research. 2005. June 1, 11 (11): PubMed Suppl DataEnver,T., Soneji,S., Joshi,C., Brown,J., Iborra,F., Orntoft,T., Thykjaer,T., Maltby,E., Smith,K., Abu,D.R., Jones,M., Matin,M., Gokhale,P., Draper,J. and Andrews,P.W. Cellular differentiation hierarchies in normal and culture-adapted human embryonic stem cells. Hum Mol Genet. 2005 Nov 1;14(21):3129-40. Epub 2005 Sep 13. PubMed
Eschrich,S., Yang,I., Bloom,G., Kwong,K.Y., Boulware,D., Cantor,A., Coppola,D., Kruhoffer,M., Aaltonen,L., Orntoft,T.F., Quackenbush,J., Yeatman,T.J. Molecular staging for survival prediction of colorectal cancer patients. J Clin.Oncol.. 23(15): 3526-3535. 2005. PubMedEwald,H., Wikman,F.P., Teruel,B.M., Buttenschon,H.N., Torralba,M., Als,T.D., El,Daoud A., Flint,T.J., Jorgensen,T.H., Blanco,L., Kruse,T.A., Orntoft,T.F., Mors,O. A genome-wide search for risk genes using homozygosity mapping and microarrays with 1,494 single-nucleotide polymorphisms in 22 eastern Cuban families with bipolar disorder. Am.J Med Genet.B Neuropsychiatr.Genet.. 133(1): 25-30. 2005. PubMed
Harnacke K, Kruhoffer M, Orntoft TF, Hass R. Down-modulation of poly(ADP-ribose) polymerase-1 (PARP-1) in human TUR leukemia cells restores transcriptional responsiveness for differentiation and cell cycle arrest. Eur J Cell Biol. 2005 Nov;84(11):885-96. PubMedKalbe,L., Leunda,A., Sparre,T., Meulemans,C., Ahn,M.T., Orntoft,T., Kruhoffer,M., Reusens,B., Nerup,J., Remacle,C. Nutritional regulation of proteases involved in fetal rat insulin secretion and islet cell proliferation. Br.J Nutr.. 93(3): 309-316. 2005. PubMed
Koed, K., Wiuf,C., Christensen, L.L., Wikman, F., Zieger, K., Møller, K., von der Maase, H., Ørntoft, T.F. High-density single nucleotide polymorphism array defines novel stage and location-dependent allelic imbalances in human bladder tumors. Cancer Research. 2005. 65 (1):34-45. PubMed Suppl data
Kristensen TN, Sørensen P, Kruhøffer M, Pedersen KS, and Loeschcke V. Genome wide analysis on inbreeding effects on gene expression in Drosophila melanogaster. Genetics. 2005 Sep;171(1):157-67. Epub 2005 Jun 8. PubMed
Kruhøffer, M., Jensen J.L., Laiho, P., Dyrskjøt, L., Salovaara, R., Arango, D., Birkenkamp-Demtroder, K., Christensen, L.L., Sørensen, F.B., Buhl, L., Mecklin J-P., Järvinen, H., Thykjaer, T., Wikman, F.P., Bech-Knudsen, F., Juhola, M., Nupponen, N.N., Lauerberg, S., Andersen, C.L., Aaltonen, L.A. and Ørntoft, T.F. (2005) Gene expression signatures for colorectal cancer microsatellite status and HNPCC. British Journal of Cancer. 2005 Jun 20;92(12):2240-8. PubMed
Lund,L., Moller Ernst-Jensen,K., Torring,N. and Erik,N.J. Impact of finasteride treatment on perioperative bleeding before transurethral resection of the prostate: a prospective randomized study, Scand.J Urol.Nephrol., 39: 160-162, 2005. PubMed
Magnusson NE, Cardozo AK, Kruhoffer M, Eizirik DL, Orntoft TF, Jensen JL. Construction and validation of the APOCHIP, a spotted oligo-microarray for the study of beta-cell apoptosis. BMC Bioinformatics. 2005 Dec 29;6(1):311 [Epub ahead of print] PubMed
Magnusson,N.E., Larsen,A., Rungby,J., Kruhoffer,M., Orntoft,T.F., Stoltenberg,M. Gene expression changes induced by bismuth in a macrophage cell line. Cell Tissue Res. 2005 Aug;321(2):195-210. Epub 2005 May 24. PubMed
Melillo,R.M., Castellone,M.D., Guarino,V., De,Falco,V, Cirafici,A.M., Salvatore,G., Caiazzo,F., Basolo,F., Giannini,R., Kruhoffer,M., Orntoft,T., Fusco,A., Santoro,M. The RET/PTC-RAS-BRAF linear signaling cascade mediates the motile and mitogenic phenotype of thyroid cancer cells. J Clin.Invest. (021-9738): . 2005. PubMedNielsen,K., Heegaard,S., Vorum,H., Birkenkamp-Demtroeder,K., Ehlers,N., Orntoft,T. Altered gene and protein expression of CLC, DSG3, EMP3, S100A2, and SLPI in corneal epithelium from keratoconus patients. Cornea. 2005 Aug;24(6):661-8. PubMed
Olesen, S.H., Christensen, L.L., Sørensen, F.B., Cabezon, T., Laurberg, S., Ørntoft, T.F., Birkenkamp-Demtröder, K.Human FK506 binding protein 65 is associated with colorectal cancer. Mol Cell Proteomics. 2005, Jan 25 (Epub ahead of print). PubMedOrntoft,T.F. [Genomic classification of diseases], Ugeskr.Laeger, 167: 2164-2167, 2005 PubMed
Pallante,P., Berlingieri,M.T., Troncone,G., Kruhoffer,M., Orntoft,T.F., Viglietto,G., Caleo,A., Migliaccio,I., caussin-Petrucci,M., Santoro,M., Palombini,L. and Fusco,A. UbcH10 overexpression may represent a marker of anaplastic thyroid carcinomas, Br.J Cancer, 93: 464-471, 2005. PubMedRipa,R.S., Katballe,N., Wikman,F.P., Jager,A.C., Bernstein,I., Orntoft,T., Schwartz,M., Nielsen,F.C., Bisgaard,M.L. Presymptomatic diagnosis using a deletion of a single codon in families with hereditary non-polyposis colorectal cancer. Mutat.Res.. 570(1): 89-96. 2005. PubMed
Sorensen JG, Nielsen MM, Kruhoffer M, Justesen J, Loeschcke V. Full genome gene expression analysis of the heat stress response in Drosophila melanogaster. Cell Stress Chaperones. 2005 Winter;10(4):312-28. PubMedTorring,N., Hansen,F.D., Sorensen,B.S., Orntoft,T.F. and Nexo,E.Increase in amphiregulin and epiregulin in prostate cancer xenograft after androgen deprivation-impact of specific HER1 inhibition, Prostate. 2005; Jun 15;64(1):1-8 PubMed
Zieger K, Dyrskjot L, Wiuf C, Jensen JL, Andersen CL, Jensen KM, Orntoft TF. Role of activating fibroblast growth factor receptor 3 mutations in the development of bladder tumors. Clin Cancer Res. 2005 Nov 1;11(21):7709-19. PubMed
1996 -2004
2004
Andersen,C.L., Jensen,J.L., Orntoft,T.F. Normalization of real-time quantitative reverse transcription-PCR data: a model-based variance estimation approach to identify genes suited for normalization, applied to bladder and colon cancer data sets. Cancer Res.. 64(15): 5245-5250. 2004. PubMedSuppl data
Bartkova,J., Guldberg,P., Gronbaek,K., Koed,K., Primdahl,H., Moller,K., Lukas,J., Orntoft,T.F., Bartek,J. Aberrations of the Chk2 tumour suppressor in advanced urinary bladder cancer. Oncogene. (950-9232): . 2004. PubMed
Castellone,M.D., Celetti,A., Guarino,V., Cirafici,A.M., Basolo,F., Giannini,R., Medico,E., Kruhoffer,M., Orntoft,T.F., Curcio,F., Fusco,A., Melillo,R.M., Santoro,M. Autocrine stimulation by osteopontin plays a pivotal role in the expression of the mitogenic and invasive phenotype of RET/PTC-transformed thyroid cells. Oncogene. 23(12): 2188-2196. 2004. PubMed
Castellone,M.D., Guarino,V., De,Falco,V, Carlomagno,F., Basolo,F., Faviana,P., Kruhoffer,M., Orntoft,T., Russell,J.P., Rothstein,J.L., Fusco,A., Santoro,M., Melillo,R.M. Functional expression of the CXCR4 chemokine receptor is induced by RET/PTC oncogenes and is a common event in human papillary thyroid carcinomas. Oncogene. (950-9232): . 2004. PubMed
Cheng,J.C., Yoo,C.B., Weisenberger,D.J., Chuang,J., Wozniak,C., Liang,G., Marquez,V.E., Greer,S., Orntoft,T.F., Thykjaer,T., Jones,P.A. Preferential response of cancer cells to zebularine. Cancer Cell. 6(2): 151-158. 2004. PubMed
Dyrskjot,L., Kruhoffer,M., Thykjaer,T., Marcussen,N., Jensen,J.L., Moller,K., Orntoft,T.F. Gene expression in the urinary bladder: a common carcinoma in situ gene expression signature exists disregarding histopathological classification. Cancer Res.. 64(11): 4040-4048. 2004. PubMed Suppl data GEO data
Ewald,H., Wikman,F.P., Teruel,B.M., Buttenschon,H.N., Torralba,M., Als,T.D., El,Daoud A., Flint,T.J., Jorgensen,T.H., Blanco,L., Kruse,T.A., Orntoft,T.F., Mors,O. A genome-wide search for risk genes using homozygosity mapping and microarrays with 1,494 single-nucleotide polymorphisms in 22 eastern Cuban families with bipolar disorder. Am.J Med Genet.. (148-7299): . 2004. PubMed
Grove,E.L., Orntoft,T.F., Lassen,J.F., Jensen,H.K., Kristensen , S.D. The platelet polymorphism PlA2 is a genetic risk factor for myocardial infarction. J.Intern.Med.. 255(6): 637-644. 2004. PubMed
Hoyos,J.M., Fedele,M., Battista,S., Pentimalli,F., Kruhoffer,M., Arra,C., Orntoft,T.F., Croce,C.M., Fusco,A. Identification of the genes up- and down-regulated by the high mobility group A1 (HMGA1) proteins: tissue specificity of the HMGA1-dependent gene regulation. Cancer Res.. 64(16): 5728-5735. 2004. PubMed
Karlsen,A.E., Heding,P.E., Frobose,H., Ronn,S.G., Kruhoffer,M., Orntoft,T.F., Darville,M., Eizirik,D.L., Pociot,F., Nerup,J., Mandrup-Poulsen,T., Billestrup,N. Suppressor of cytokine signalling (SOCS)-3 protects beta cells against IL-1beta-mediated toxicity through inhibition of multiple nuclear factor-kappaB-regulated proapoptotic pathways. Diabetologia. 47(11): 1998-2011. 2004. PubMed
Lardon,J., De Breuck,S., Rooman, I. , Van Lommel,L., Kruhoffer,M., Orntoft,T., Schuit,F., Bouwens,L. Plasticity in the adult rat pancreas: transdifferentiation of exocrine to hepatocyte-like cells in primary culture. Hepatology. 39(6): 1499-1507. 2004. PubMed
Nielsen,K., Kruhoffer,M., Orntoft,T., Sparre,T., Wang,H., Wollheim,C., Jorgensen,M.C., Nerup,J., Karlsen,A.E. Gene expression profiles during beta cell maturation and after IL-1beta exposure reveal important roles of Pdx-1 and Nkx6.1 for IL-1beta sensitivity. Diabetologia. (012-186X): . 2004. PubMed
Sorensen,B.S., Torring,N., Bor,M.V., Nexo,E. The DNA damaging agent VP16 induces the expression of a subset of ligands from the EGF system in bladder cancer cells, whereas none of the four EGF receptors are induced. Mol.Cell Biochem.. 260(1-2): 129-135. 2004. PubMed
Vermijlen,D., Seynaeve,C., Luo,D., Kruhoffer,M., Eizirik,D.L., Orntoft,T.F., Wisse,E. High-density oligonucleotide array analysis reveals extensive differences between freshly isolated blood and hepatic natural killer cells. Eur.J.Immunol.. 34(9): 2529-2540. 2004. PubMed
2003
Cardozo,A.K., Berthou,L., Kruhoffer,M., Orntoft,T., Nicolls,M.R., Eizirik,D.L. Gene microarray study corroborates proteomic findings in rodent islet cells. J.Proteome.Res.. 2(5): 553-555. 2003. PubMed
Celis,J.E., Gromov,P., Gromova,I., Moreira,J.M., Cabezon,T., Ambartsumian,N., Grigorian,M., Lukanidin,E., Thor,Straten P., Guldberg,P., Bartkova,J., Bartek,J., Lukas,J., Lukas,C., Lykkesfeldt,A., Jaattela,M., Roepstorff,P., Bolund,L., Orntoft,T., Brunner,N., Overgaard,J., Sandelin,K., Blichert-Toft,M., Mouridsen,H., Rank,F.E. Integrating Proteomic and Functional Genomic Technologies in Discovery-driven Translational Breast Cancer Research. Mol.Cell Proteomics.. 2(6): 369-377. 2003. PubMed
Dyrskjot,L., Thykjaer,T., Kruhoffer,M., Jensen,J.L., Marcussen,N., Hamilton-Dutoit,S., Wolf,H., Orntoft,T.F. Identifying distinct classes of bladder carcinoma using microarrays. Nat.Genet.. 33(1): 90-96. 2003. PubMed GEO data GSE88 GEO data GSE89
Dyrskjot,L. Classification of bladder cancer by microarray expression profiling: towards a general clinical use of microarrays in cancer diagnostics. Expert Rev Mol Diagn 2003; 3(5):635-647. PubMed
Frederiksen,C.M., Aaboe,M., Dyrskjot,L., Laurberg,S., Wolf,H., Orntoft,T.F., Kruhoffer,M. Technical evaluation of cDNA microarrays. APMIS Suppl. (109): 96-101. 2003. PubMed
Frederiksen,C.M., Knudsen,S., Laurberg,S., Orntoft,T.F. Classification of Dukes' B and C colorectal cancers using expression arrays. J.Cancer Res.Clin.Oncol.. 129(5): 263-271. 2003. PubMed
Hansen,L.T., Thykjaer,T., Orntoft,T.F., Rasmussen,L.J., Keller,P., Spang-Thomsen,M., Edmonston,T.B., Schmutte,C., Fishel,R., Petersen,L.N. The role of mismatch repair in small-cell lung cancer cells.Eur.J.Cancer. 39(10): 1456-1467. 2003. PubMed
Jagmohan-Changur,S., Poikonen,T., Vilkki,S., Launonen,V., Wikman,F., Orntoft,T.F., Moller,P., Vasen,H., Tops,C., Kolodner,R.D., Mecklin,J.P., Jarvinen,H., Bevan,S., Houlston,R.S., Aaltonen,L.A., Fodde,R., Wijnen,J., Karhu,A. EXO1 variants occur commonly in normal population: evidence against a role in hereditary nonpolyposis colorectal cancer. Cancer Res.. 63(1): 154-158. 2003. PubMed
Jeppesen,P.B., Gregersen,S., Rolfsen,S.E., Jepsen,M., Colombo,M., Agger,A., Xiao,J., Kruhoffer,M., Orntoft,T., Hermansen,K. Antihyperglycemic and blood pressure-reducing effects of stevioside in the diabetic Goto-Kakizaki rat. Metabolism. 52(3): 372-378. 2003. PubMed
Kutlu,B., Cardozo,A.K., Darville,M.I., Kruhoffer,M., Magnusson,N., Orntoft,T., Eizirik,D.L. Discovery of gene networks regulating cytokine-induced dysfunction and apoptosis in insulin-producing INS-1 cells. Diabetes. 52(11): 2701-2719. 2003. PubMed
Laiho,P., Hienonen,T., Karhu,A., Lipton,L., Aalto,Y., Thomas,H.J., Birkenkamp-Demtroder,K., Hodgson,S., Salovaara,R., Mecklin,J.P., Jarvinen,H., Knuutila,S., Halford,S., Orntoft,T.F., Tomlinson,I., Launonen,V., Houlston,R., Aaltonen,L.A. Genome-wide allelotyping of 104 Finnish colorectal cancers reveals an excess of allelic imbalance in chromosome 20q in familial cases. Oncogene. 22(14): 2206-2214. 2003. PubMed
Moraes,R.C., Blondet,A., Birkenkamp-Demtroeder,K., Tirard,J., Orntoft,T.F., Gertler,A., Durand,P., Naville,D., Begeot,M. Study of the alteration of gene expression in adipose tissue of diet-induced obese mice by microarray and reverse transcription-polymerase chain reaction analyses. Endocrinology. 144(11): 4773-4782. 2003. PubMed
Nielsen,K., Birkenkamp-Demtroder,K., Ehlers,N., Orntoft,T.F. Identification of differentially expressed genes in keratoconus epithelium analyzed on microarrays. Invest Ophthalmol.Vis.Sci.. 44(6): 2466-2476. 2003. PubMed
Orntoft,T.F. [DNA microarrays (DNA chips) used in molecular medical research]. Ugeskr.Laeger. 165(8): 786-790. 2003. PubMed
Orntoft,T.F., Nielsen,O.S. [Comment to the article "Nepotism in peer review of applications for research grants"]. Ugeskr.Laeger. 165(48): 4638-4640. 2003. PubMed
Rasschaert,J., Liu,D., Kutlu,B., Cardozo,A.K., Kruhoffer,M., Orntoft,T.F., Eizirik,D.L. Global profiling of double stranded RNA- and IFN-gamma-induced genes in rat pancreatic beta cells. Diabetologia. 46(12): 1641-1657. 2003. PubMed
Sieber,O.M., Lipton,L., Crabtree,M., Heinimann,K., Fidalgo,P., Phillips,R.K., Bisgaard,M.L., Orntoft,T.F., Aaltonen,L.A., Hodgson,S.V., Thomas,H.J., Tomlinson,I.P. Multiple colorectal adenomas, classic adenomatous polyposis, and germ-line mutations in MYH. N.Engl.J.Med.. 348(9): 791-799. 2003. PubMed
Vallat,L., Magdelenat,H., Merle-Beral,H., Masdehors,P., Potocki,de Montalk, Davi,F., Kruhoffer,M., Sabatier,L., Orntoft,T.F., Delic,J. The resistance of B-CLL cells to DNA damage-induced apoptosis defined by DNA microarrays. Blood. 101(11): 4598-4606. 2003. PubMed
2002
Birkenkamp-Demtroder,K., Christensen,L.L., Olesen,S.H., Frederiksen,C.M., Laiho,P., Aaltonen,L.A., Laurberg,S., Sorensen,F.B., Hagemann,R., Orntoft,T.F. Gene expression in colorectal cancer. Cancer Res.. 62(15): 4352-4363. 2002. PubMed
Celis,J.E., Celis,P., Palsdottir,H., Ostergaard,M., Gromov,P., Primdahl,H., Orntoft,T.F., Wolf,H., Celis,A., Gromova,I. Proteomic strategies to reveal tumor heterogeneity among urothelial papillomas. Mol.Cell Proteomics.. 1(4): 269-279. 2002. PubMed
Christensen,M., Katballe,N., Wikman,F., Primdahl,H., Sorensen,F.B., Laurberg,S., Orntoft,T.F. Antibody-based screening for hereditary nonpolyposis colorectal carcinoma compared with microsatellite analysis and sequencing. Cancer. 95(11): 2422-2430. 2002. PubMed
De Vos,J., Thykjaer,T., Tarte,K., Ensslen,M., Raynaud,P., Requirand,G., Pellet,F., Pantesco,V., Reme,T., Jourdan,M., Rossi,J.F., Orntoft,T., Klein,B. Comparison of gene expression profiling between malignant and normal plasma cells with oligonucleotide arrays. Oncogene. 21(44): 6848-6857. 2002. PubMed
Flamez,D., Berger,V., Kruhoffer,M., Orntoft,T., Pipeleers,D., Schuit,F.C. Critical role for cataplerosis via citrate in glucose-regulated insulin release. Diabetes. 51(7): 2018-2024. 2002. PubMed
Hilpert,J., Wogensen,L., Thykjaer,T., Wellner,M., Schlichting,U., Orntoft,T.F., Bachmann,S., Nykjaer,A., Willnow,T.E. Expression profiling confirms the role of endocytic receptor megalin in renal vitamin D3 metabolism. Kidney Int.. 62(5): 1672-1681. 2002. PubMed
Katballe,N., Christensen,M., Wikman,F.P., Orntoft,T.F., Laurberg,S. Frequency of hereditary non-polyposis colorectal cancer in Danish colorectal cancer patients. Gut. 50(1): 43-51. 2002. PubMed
Kennan,A., Aherne,A., Palfi,A., Humphries,M., McKee,A., Stitt,A., Simpson,D.A., Demtroder,K., Orntoft,T., Ayuso,C., Kenna,P.F., Farrar,G.J., Humphries,P. Identification of an IMPDH1 mutation in autosomal dominant retinitis pigmentosa (RP10) revealed following comparative microarray analysis of transcripts derived from retinas of wild-type and Rho(-/-) mice. Hum.Mol.Genet.. 11(5): 547-557. 2002. PubMed
Liang,G., Gonzales,F.A., Jones,P.A., Orntoft,T.F., Thykjaer,T. Analysis of gene induction in human fibroblasts and bladder cancer cells exposed to the methylation inhibitor 5-aza-2'-deoxycytidine. Cancer Res.. 62(4): 961-966. 2002. PubMed
Lu,M.L., Wikman,F., Orntoft,T.F., Charytonowicz,E., Rabbani,F., Zhang,Z., Dalbagni,G., Pohar,K.S., Yu,G., Cordon-Cardo,C. Impact of alterations affecting the p53 pathway in bladder cancer on clinical outcome, assessed by conventional and array-based methods. Clin.Cancer Res.. 8(1): 171-179. 2002. PubMed
Orntoft,T.F., Thykjaer,T., Waldman,F.M., Wolf,H., Celis,J.E. Genome-wide study of gene copy numbers, transcripts, and protein levels in pairs of non-invasive and invasive human transitional cell carcinomas. Mol.Cell Proteomics.. 1(1): 37-45. 2002. PubMed
Primdahl,H., von der,Maase H., Christensen,M., Wolf,H., Orntoft,T.F. Allelic deletions of Rb and L-myc in urine sediments from patients with bladder tumors or carcinoma in situ. Oncol.Rep.. 9(3): 551-555. 2002. PubMed
Primdahl,H., von der,Maase H., Sorensen,F.B., Wolf,H., Orntoft,T.F. Immunohistochemical study of the expression of cell cycle regulating proteins at different stages of bladder cancer. J.Cancer Res.Clin.Oncol.. 128(6): 295-301. 2002. PubMed
Primdahl,H., Wikman,F.P., von der,Maase H., Zhou,X.G., Wolf,H., Orntoft,T.F. Allelic imbalances in human bladder cancer: genome-wide detection with high-density single-nucleotide polymorphism arrays. J.Natl.Cancer Inst.. 94(3): 216-223. 2002. PubMed Suppl data
Spicker,J.S., Wikman,F., Lu,M.L., Cordon-Cardo,C., Workman,C., Orntoft,T.F., Brunak,S., Knudsen,S. Neural network predicts sequence of TP53 gene based on DNA chip. Bioinformatics.. 18(8): 1133-1134. 2002. PubMed
Tarte,K., De Vos,J., Thykjaer,T., Zhan,F., Fiol,G., Costes,V., Reme,T., Legouffe,E., Rossi,J.F., Shaughnessy,J.,Jr., Orntoft,T.F., Klein,B. Generation of polyclonal plasmablasts from peripheral blood B cells: a normal counterpart of malignant plasmablasts. Blood. 100(4): 1113-1122. 2002. PubMed
Vermijlen,D., Luo,D., Kruhoffer,M., Orntoft,T.F., Kuppen,P.J., Wisse,E. Is the presence of interleukin-2 receptor alpha in the serum of colorectal liver metastases patients derived from hepatic natural killer cells?. Cancer Immunol.Immunother.. 51(5): 291-292. 2002. PubMed
2001
Cardozo,A.K., Kruhoffer,M., Leeman,R., Orntoft,T., Eizirik,D.L. Identification of novel cytokine-induced genes in pancreatic beta-cells by high-density oligonucleotide arrays. Diabetes. 50(5): 909-920. 2001. PubMed
Cardozo,A.K., Heimberg,H., Heremans,Y., Leeman,R., Kutlu,B., Kruhoffer,M., Orntoft,T., Eizirik,D.L. A comprehensive analysis of cytokine-induced and nuclear factor-kappa B-dependent genes in primary rat pancreatic beta-cells.J.Biol.Chem.. 276(52): 48879-48886. 2001. PubMed
Herbsleb,M., Knudsen,U.B., Orntoft,T.F., Bichel,P., Norrild,B., Knudsen,A., Mogensen,O. Telomerase activity, MIB-1, PCNA, HPV 16 and p53 as diagnostic markers for cervical intraepithelial neoplasia. APMIS. 109(9): 607-617. 2001. PubMed
Katballe,N., Bentzen,S.M., Christensen,M., Wikman,F.P., Orntoft,T., Laurberg,S. Role of chance in familial aggregation of colorectal cancer. Br.J.Cancer. 84(8): 1084-1086. 2001. PubMed
Katballe,N., Juul,S., Christensen,M., Orntoft,T.F., Wikman,F.P., Laurberg,S. Patient accuracy of reporting on hereditary non-polyposis colorectal cancer-related malignancy in family members. Br.J.Surg.. 88(9): 1228-1233. 2001. PubMed
Muller,W., Burgart,L.J., Krause-Paulus,R., Thibodeau,S.N., Almeida,M., Edmonston,T.B., Boland,C.R., Sutter,C., Jass,J.R., Lindblom,A., Lubinski,J., MacDermot,K., Sanders,D.S., Morreau,H., Muller,A., Oliani,C., Orntoft,T., Ponz,De Leon, Rosty,C., Rodriguez-Bigas,M., Ruschoff,J., Ruszkiewicz,A., Sabourin,J., Salovaara,R., Moslein,G. The reliability of immunohistochemistry as a prescreening method for the diagnosis of hereditary nonpolyposis colorectal cancer (HNPCC)--results of an international collaborative study. Fam.Cancer. 1(2): 87-92. 2001. PubMed
Olesen,S.H., Thykjaer,T., Orntoft,T.F. Mitotic checkpoint genes hBUB1, hBUB1B, hBUB3 and TTK in human bladder cancer, screening for mutations and loss of heterozygosity. Carcinogenesis. 22(5): 813-815. 2001. PubMed Suppl data
Pedersen,M.W., Thykjaer,T., Orntoft,T.F., Damstrup,L., Poulsen,H.S. Profile of differentially expressed genes mediated by the type III epidermal growth factor receptor mutation expressed in a small-cell lung cancer cell line. Br.J.Cancer. 85(8): 1211-1218. 2001. PubMed
Thogersen,V.B., Sorensen,B.S., Poulsen,S.S., Orntoft,T.F., Wolf,H., Nexo,E. A subclass of HER1 ligands are prognostic markers for survival in bladder cancer patients. Cancer Res.. 61(16): 6227-6233. 2001. PubMed
Thykjaer,T., Christensen,M., Clark,A.B., Hansen,L.R., Kunkel,T.A., Orntoft,T.F. Functional analysis of the mismatch repair system in bladder cancer. Br.J.Cancer. 85(4): 568-575. 2001. PubMed
Thykjaer,T., Workman,C., Kruhoffer,M., Demtroder,K., Wolf,H., Andersen,L.D., Frederiksen,C.M., Knudsen,S., Orntoft,T.F. Identification of gene expression patterns in superficial and invasive human bladder cancer. Cancer Res.. 61(6): 2492-2499. 2001. PubMed Suppl data
Wyttenbach,A., Swartz,J., Kita,H., Thykjaer,T., Carmichael,J., Bradley,J., Brown,R., Maxwell,M., Schapira,A., Orntoft,T.F., Kato,K., Rubinsztein,D.C. Polyglutamine expansions cause decreased CRE-mediated transcription and early gene expression changes prior to cell death in an inducible cell model of Huntington's disease. Hum.Mol.Genet.. 10(17): 1829-1845. 2001. PubMed
Xiao,J., Gregersen,S., Kruhoffer,M., Pedersen,S.B., Orntoft,T.F., Hermansen,K. The effect of chronic exposure to fatty acids on gene expression in clonal insulin-producing cells: studies using high density oligonucleotide microarray. Endocrinology. 142(11): 4777-4784. 2001. PubMed
2000
Celis,J.E., Kruhoffer,M., Gromova,I., Frederiksen,C., Ostergaard,M., Thykjaer,T., Gromov,P., Yu,J., Palsdottir,H., Magnusson,N., Orntoft,T.F. Gene expression profiling: monitoring transcription and translation products using DNA microarrays and proteomics. FEBS Lett.. 480(1): 2-16. 2000. PubMed
Christensen,L.L., Jensen,U.B., Bross,P., Orntoft,T.F. The C-terminal N-glycosylation sites of the human alpha1,3/4-fucosyltransferase III, -V, and -VI (hFucTIII, -V, adn -VI) are necessary for the expression of full enzyme activity. Glycobiology. 10(9): 931-939. 2000. PubMed
Christensen,L.L., Bross,P., Orntoft,T.F. Glycosylation of the N-terminal potential N-glycosylation sites in the human alpha1,3-fucosyltransferase V and -VI (hFucTV and -VI). Glycoconj.J.. 17(12): 859-865. 2000. PubMed
Christensen,M., Wolf,H., Orntoft,T.F. Microsatellite alterations in urinary sediments from patients with cystitis and bladder cancer. Int.J.Cancer. 85(5): 614-617. 2000. PubMed
Orntoft,I., Bonding,P. Choanal adenoid syndrome--a preliminary report. Acta Otolaryngol.Suppl. 543(365-5237): 220-221. 2000. PubMed
Pedersen,L.N., Kjaer,H.O., Moller,J.K., Orntoft,T.F., Ostergaard,L. High-resolution genotyping of Chlamydia trachomatis from recurrent urogenital infections. J.Clin.Microbiol.. 38(8): 3068-3071. 2000. PubMed
Primdahl,H., von der,Maase H., Christensen,M., Wolf,H., Orntoft,T.F. Allelic deletions of cell growth regulators during progression of bladder cancer. Cancer Res.. 60(23): 6623-6629. 2000. PubMed
Sengelov,L., Christensen,M., der Maase,H.D., Horn,T., Marcussen,N., Kamby,C., Orntoft,T. Loss of heterozygosity at 1p, 8p, 10p, 13q, and 17p in advanced urothelial cancer and lack of relation to chemotherapy response and outcome. Cancer Genet.Cytogenet.. 123(2): 109-113. 2000. PubMed
Tos,M., Orntoft,S., Stangerup,S.E. Results of tympanoplasty in children after 15 to 27 years. Ann.Otol.Rhinol.Laryngol.. 109(1): 17-23. 2000. PubMed
Tos,M., Stangerup,S.E., Orntoft,S. Reasons for reperforation after tympanoplasty in children. Acta Otolaryngol.Suppl. 543(365-5237): 143-146. 2000. PubMed
Wikman,F.P., Katballe,N., Christensen,M., Laurberg,S., Orntoft,T.F. Efficient mutation detection in mismatch repair genes using a combination of single-strand conformational polymorphism and heteroduplex analysis at a controlled temperature. Genet.Test.. 4(1): 15-21. 2000. PubMed
Wikman,F.P., Lu,M.L., Thykjaer,T., Olesen,S.H., Andersen,L.D., Cordon-Cardo,C., Orntoft,T.F. Evaluation of the performance of a p53 sequencing microarray chip using 140 previously sequenced bladder tumor samples. Clin.Chem.. 46(10): 1555-1561. 2000. PubMed Suppl data
1999
Celis,A., Rasmussen,H.H., Celis,P., Basse,B., Lauridsen,J.B., Ratz,G., Hein,B., Ostergaard,M., Wolf,H., Orntoft,T., Celis,J.E. Short-term culturing of low-grade superficial bladder transitional cell carcinomas leads to changes in the expression levels of several proteins involved in key cellular activities. Electrophoresis. 20(2): 355-361. 1999. PubMed
Celis,J.E., Celis,P., Ostergaard,M., Basse,B., Lauridsen,J.B., Ratz,G., Rasmussen,H.H., Orntoft,T.F., Hein,B., Wolf,H., Celis,A. Proteomics and immunohistochemistry define some of the steps involved in the squamous differentiation of the bladder transitional epithelium: a novel strategy for identifying metaplastic lesions. Cancer Res.. 59(12): 3003-3009. 1999. PubMed
Celis,J.E., Ostergaard,M., Rasmussen,H.H., Gromov,P., Gromova,I., Varmark,H., Palsdottir,H., Magnusson,N., Andersen,I., Basse,B., Lauridsen,J.B., Ratz,G., Wolf,H., Orntoft,T.F., Celis,P., Celis,A. A comprehensive protein resource for the study of bladder cancer: http://biobase.dk/cgi-bin/celis. Electrophoresis. 20(2): 300-309. 1999. PubMed
Christensen,M., Sunde,L., Bolund,L., Orntoft,T.F. Comparison of three methods of microsatellite detection. Scand.J.Clin.Lab Invest. 59(3): 167-177. 1999. PubMed
Orntoft,T.F., Vestergaard,E.M. Clinical aspects of altered glycosylation of glycoproteins in cancer. Electrophoresis. 20(2): 362-371. 1999. PubMed
Ostergaard,M., Wolf,H., Orntoft,T.F., Celis,J.E. Psoriasin (S100A7): a putative urinary marker for the follow-up of patients with bladder squamous cell carcinomas. Electrophoresis. 20(2): 349-354. 1999. PubMed
Skorstengaard,K., Vestergaard,E.M., Langkilde,N.C., Christensen,L.L., Wolf,H., Orntoft,T.F. Lewis antigen mediated adhesion of freshly removed human bladder tumors to E-selectin. J.Urol.. 161(4): 1316-1323. 1999. PubMed
Thogersen,V.B., Jorgensen,P.E., Sorensen,B.S., Bross,P., Orntoft,T., Wolf,H., Nexo,E. Expression of transforming growth factor alpha and epidermal growth factor receptor in human bladder cancer. Scand.J.Clin.Lab Invest. 59(4): 267-277. 1999. PubMed
Vestergaard,E.M., Hein,H.O., Meyer,H., Grunnet,N., Jorgensen,J., Wolf,H., Orntoft,T.F. Reference values and biological variation for tumor marker CA 19-9 in serum for different Lewis and secretor genotypes and evaluation of secretor and Lewis genotyping in a Caucasian population. Clin.Chem.. 45(1): 54-61. 1999. PubMed
1998
Bech,E., Andersen,H., Orntoft,T.F., Jakobsen,J. Association of IgM type anti-GM1 antibodies and muscle strength in chronic acquired demyelinating polyneuropathy. Ann.Neurol.. 43(1): 72-78. 1998. PubMed
Christensen,M., Jensen,M.A., Wolf,H., Orntoft,T.F. Pronounced microsatellite instability in transitional cell carcinomas from young patients with bladder cancer. Int.J.Cancer. 79(4): 396-401. 1998. PubMed
Mayer,M., Wilkinson,I., Heikkinen,R., Orntoft,T., Magid,E. Improved laboratory test selection and enhanced perception of test results as tools for cost-effective medicine. Clin.Chem.Lab Med.. 36(9): 683-690. 1998. PubMed
Orntoft,T.F., Wolf,H. Molecular alterations in bladder cancer. Urol.Res.. 26(4): 223-233. 1998. PubMed
Tos,M., Svendstrup,F., Arndal,H., Orntoft,S., Jakobsen,J., Borum,P., Schrewelius,C., Larsen,P.L., Clement,F., Barfoed,C., Romeling,F., Tvermosegaard,T. Efficacy of an aqueous and a powder formulation of nasal budesonide compared in patients with nasal polyps. Am.J.Rhinol.. 12(3): 183-189. 1998. PubMed
Vestergaard,E.M., Wolf,H., Orntoft,T.F. Increased concentrations of genotype-interpreted Ca 19-9 in urine of bladder cancer patients mark diffuse atypia of the urothelium. Clin.Chem.. 44(2): 197-204. 1998. PubMed
Vinter-Jensen,L., Orntoft,T.F. Glycoproteins in the urothelium and in the urine of the epidermal growth factor induced growing urinary tract in rats. Urol.Res.. 26(2): 97-103. 1998. PubMed
1997
Bech,E., Orntoft,T.F., Andersen,L.P., Skinhoj,P., Jakobsen,J. IgM anti-GM1 antibodies in the Guillain-Barre syndrome: a serological predictor of the clinical course. J.Neuroimmunol.. 72(1): 59-66. 1997. PubMed
Nielsen,H., Orntoft,S., Nielsen,T.G. Change in minimal cross sectional area using the new nasal dilator, "Airplus". Acta Otolaryngol.Suppl. 529(365-5237): 130-132. 1997. PubMed
Orntoft,T.F., Jepsen,J., Hansen,P.V., Raundahl,U., Langkilde,N.C. A two-site lectinoenzymatic assay for determination of tumour marker glycoproteins in rectal secretions.Glycoconj.J.. 14(2): 191-199. 1997. PubMed
Ostergaard,M., Rasmussen,H.H., Nielsen,H.V., Vorum,H., Orntoft,T.F., Wolf,H., Celis,J.E. Proteome profiling of bladder squamous cell carcinomas: identification of markers that define their degree of differentiation. Cancer Res.. 57(18): 4111-4117. 1997. PubMed
1996
Celis,J.E., Ostergaard,M., Basse,B., Celis,A., Lauridsen,J.B., Ratz,G.P., Andersen,I., Hein,B., Wolf,H., Orntoft,T.F., Rasmussen,H.H. Loss of adipocyte-type fatty acid binding protein and other protein biomarkers is associated with progression of human bladder transitional cell carcinomas. Cancer Res.. 56(20): 4782-4790. 1996. PubMed
Celis,J.E., Rasmussen,H.H., Vorum,H., Madsen,P., Honore,B., Wolf,H., Orntoft,T.F. Bladder squamous cell carcinomas express psoriasin and externalize it to the urine. J.Urol.. 155(6): 2105-2112. 1996. PubMed
Mantoni,M., Larsen,P., Hansen,H., Tos,M., Berner,B., Orntoft,S. Coronal CT of the paranasal sinuses before and after functional endoscopic sinus surgery. Eur.Radiol.. 6(6): 920-924. 1996. PubMed
Orntoft,T.F., Vestergaard,E.M., Holmes,E., Jakobsen,J.S., Grunnet,N., Mortensen,M., Johnson,P., Bross,P., Gregersen,N., Skorstengaard,K., Jensen,U.B., Bolund,L., Wolf,H. Influence of Lewis alpha1-3/4-L-fucosyltransferase (FUT3) gene mutations on enzyme activity, erythrocyte phenotyping, and circulating tumor marker sialyl-Lewis a levels. J.Biol.Chem.. 271(50): 32260-32268. 1996. PubMed
Orntoft,T.F., Meldgaard,P., Pedersen,B., Wolf,H. The blood group ABO gene transcript is down-regulated in human bladder tumors and growth-stimulated urothelial cell lines. Cancer Res.. 56(5): 1031-1036. 1996. PubMed
Rasmussen,H.H., Orntoft,T.F., Wolf,H., Celis,J.E. Towards a comprehensive database of proteins from the urine of patients with bladder cancer. J.Urol.. 155(6): 2113-2119. 1996. PubMed
Vinter-Jensen,L., Smerup,M., Jorgensen,P.E., Juhl,C.O., Orntoft,T., Poulsen,S.S., Nexo,E. Chronic treatment with epidermal growth factor stimulates growth of the urinary tract in the rat. Urol.Res.. 24(1): 15-21. 1996. PubMed