Publications

2017

Direct detection of early-stage cancers using circulating tumor DNA
Jillian Phallen, Mark Sausen, Vilmos Adleff, Alessandro Leal, Carolyn Hruban, James White, Valsamo Anagnostou, Jacob Fiksel, Stephen Cristiano, Eniko Papp, Savannah Speir, Thomas Reinert, Mai-Britt Worm Orntoft, Brian D. Woodward, Derek Murphy, Sonya Parpart-Li, David Riley, Monica Nesselbush, Naomi Sengamalay, Andrew Georgiadis, Qing Kay Li, Mogens Rørbæk Madsen, Frank Viborg Mortensen, Joost Huiskens, Cornelis Punt, Nicole van Grieken, Remond Fijneman0, Gerrit Meijer0, Hatim Husain, Robert B. Scharpf, Luis A. Diaz Jr,†, Siân Jones, Sam Angiuoli, Torben Ørntoft, Hans Jørgen Nielsen, Claus Lindbjerg Andersen and Victor E. Velculescu
Science Translational Medicine 16 Aug 2017: Vol. 9, Issue 403, eaan2415 

Clinical implications of monitoring circulating tumor DNA in patients with colorectal cancer.
Schøler LV, Reinert T, Ørntoft MW, Kassentoft CG, Árnadóttir SS, Vang S, Nordentoft I, Knudsen M, Lamy P, Andreasen D, Mortensen FV, Knudsen AR, Stribolt K, Sivesgaard K, Mouritzen P, Nielsen HJ, Laurberg S, Ørntoft TF, Andersen CL.
Clin Cancer Res. 2017 Jun 9. pii: clincanres.0510.2017. doi: 10.1158/1078-0432.CCR-17-0510. [Epub ahead of print] PubMed

An Optimized Shotgun Strategy for the Rapid Generation of Comprehensive Human Proteomes.
Bekker-Jensen DB, Kelstrup CD, Batth TS, Larsen SC, Haldrup C, Bramsen JB, Sørensen KD, Høyer S, Ørntoft TF, Andersen CL, Nielsen ML, Olsen JV.
Cell Syst. 2017 Jun 6. pii: S2405-4712(17)30188-6. doi: 10.1016/j.cels.2017.05.009. [Epub ahead of print] PubMed

Prognostic Impact of a 12-gene Progression Score in Non-muscle-invasive Bladder Cancer: A Prospective Multicentre Validation Study.
Dyrskjøt L, Reinert T, Algaba F, Christensen E, Nieboer D, Hermann GG, Mogensen K, Beukers W, Marquez M, Segersten U, Høyer S, Ulhøi BP, Hartmann A, Stöhr R, Wach S, Nawroth R, Schwamborn K, Tulic C, Simic T, Junker K, Harving N, Petersen AC, Jensen JB, Keck B, Grimm MO, Horstmann M, Maurer T, Steyerberg EW, Zwarthoff EC, Real FX, Malats N, Malmström PU, Ørntoft TF.
Eur Urol. 2017 Jun 2. pii: S0302-2838(17)30475-X. doi: 10.1016/j.eururo.2017.05.040. [Epub ahead of print] PubMed

Molecular-Subtype-Specific Biomarkers Improve Prediction of Prognosis in Colorectal Cancer.
Bramsen JB, Rasmussen MH, Ongen H, Mattesen TB, Ørntoft MW, Árnadóttir SS, Sandoval J, Laguna T, Vang S, Øster B, Lamy P, Madsen MR, Laurberg S, Esteller M, Dermitzakis ET, Ørntoft TF, Andersen CL.
Cell Rep. 2017 May 9;19(6):1268-1280. doi: 10.1016/j.celrep.2017.04.045. PubMed

Incidence and prevalence of multiple endocrine neoplasia 2B in Denmark: a nationwide study.
Mathiesen JS, Kroustrup JP, Vestergaard P, Madsen M, Stochholm K, Poulsen PL, Krogh Rasmussen Å, Feldt-Rasmussen U, Schytte S, Pedersen HB, Hahn CH, Bentzen J, Gaustadnes M, Ørntoft TF, Hansen TVO, Nielsen FC, Brixen K, Frederiksen AL, Godballe C.
Endocr Relat Cancer. 2017 Apr 24. pii: ERC-17-0122. doi: 10.1530/ERC-17-0122. [Epub ahead of print] PubMed

Profiling of long non-coding RNAs identifies LINC00958 and LINC01296 as candidate oncogenes in bladder cancer.
Seitz AK, Christensen LL, Christensen E, Faarkrog K, Ostenfeld MS, Hedegaard J, Nordentoft I, Nielsen MM, Palmfeldt J, Thomson M, Jensen MT, Nawroth R, Maurer T, Ørntoft TF, Jensen JB, Damgaard CK, Dyrskjøt L.
Sci Rep. 2017 Mar 24;7(1):395. doi: 10.1038/s41598-017-00327-0. PubMed

epiG: statistical inference and profiling of DNA methylation from whole-genome bisulfite sequencing data.
Vincent M, Mundbjerg K, Skou Pedersen J, Liang G, Jones PA, Ørntoft TF, Dalsgaard Sørensen K, Wiuf C.
Genome Biol. 2017 Feb 21;18(1):38. doi: 10.1186/s13059-017-1168-4. PubMed

Heterogeneous patterns of DNA methylation-based field effects in histologically normal prostate tissue from cancer patients.
Møller M, Strand SH, Mundbjerg K, Liang G, Gill I, Haldrup C, Borre M, Høyer S, Ørntoft TF, Sørensen KD.
Sci Rep. 2017 Jan 13;7:40636. doi: 10.1038/srep40636. PubMed

Identifying aggressive prostate cancer foci using a DNA methylation classifier.
Mundbjerg K, Chopra S, Alemozaffar M, Duymich C, Lakshminarasimhan R, Nichols PW, Aron M, Siegmund KD, Ukimura O, Aron M, Stern M, Gill P, Carpten JD, Ørntoft TF, Sørensen KD, Weisenberger DJ, Jones PA, Duddalwar V, Gill I, Liang G.
Genome Biol. 2017 Jan 12;18(1):3. doi: 10.1186/s13059-016-1129-3. PubMed

Liquid Biopsy Analysis of FGFR3 and PIK3CA Hotspot Mutations for Disease Surveillance in Bladder Cancer.
Christensen E, Birkenkamp-Demtröder K, Nordentoft I, Høyer S, van der Keur K, van Kessel K, Zwarthoff E, Agerbæk M, Ørntoft TF, Jensen JB, Dyrskjøt L.
Eur Urol. 2017 Jan 6. pii: S0302-2838(16)30920-4. doi: 10.1016/j.eururo.2016.12.016. [Epub ahead of print] PubMed